Raed M Rizkallah
Assistant Professor
Education
B.S., Biology, American University of Beirut, Beirut, Lebanon.
M.S. Molecular Biology, Lebanese American University, Byblos, Lebanon.
Ph.D., Biological Science, Department of Biological Science, Florida State University.
Postdoctoral, Department of Biomedical Sciences, College of Medicine, Florida State University.
Service
Ad hoc reviewer for the scientific journals:
Scientific Reports
Plos One
Honors/Awards
Outstanding Achievement as a Postdoctoral Scholar. The Biomedical Sciences Department Award for the year 2011-2012.
Innovator Award, FSU (2012)
Innovator Award, FSU (2011)
Memberships
American Society for Biochemistry and Molecular Biology (ASBMB)
American Society for Cell Biology (ASCB)
Publications
RESEARCH PAPERS
Gutierrez-Morton E, Haluska C, Collins L, Rizkallah R, Tomko RJ Jr, Wang Y. The polySUMOylation axis promotes nucleolar release of Tof2 for mitotic exit. Cell Rep. 2024 Jul 23;43(7):114492.
Daraiseh SI, Kassardjian A, Alexander KE, Rizkallah R, Hurt MM. c-Abl phosphorylation of Yin Yang 1's conserved tyrosine 254 in the spacer region modulates its transcriptional activity. Biochim Biophys Acta. 2018 May 25;1865(9):1173-1186.
Alexander K. and Rizkallah R. Aurora A Phosphorylation of YY1 during Mitosis Inactivates its DNA-Binding Activity. Scientific Reports. 2017. 30;7(1):10084
Rizkallah, R., Batsomboon, P., Dudley, G.B. and Hurt, M. M. Identification of the Oncogenic Kinase TOPK/PBK as a Master Mitotic Regulator of C2H2 Zinc Finger Proteins. Oncotarget. 2015 Jan 30;6(3):1446-61.
Xu, Z., Graham, K., Foote, M., Liang, F., Rizkallah, R., Hurt, M. M., Wang, Y., Wu, Y., & Zhou Y. 14-3-3 targets chaperone-associated misfolded proteins to aggresomes. J Cell Science. 2013. 126, 4173-4186.
Richmond, D., Rizkallah, R., Liang, F., Hurt, MM, and Wang Y. Slk19 clusters kinetochores and facilitates chromosome bipolar attachment. Mol.Biol.Cell. 2013. 24(5), 566-77.
Kassardjian, A., Rizkallah R., Riman S., Renfro S., Alexander K.E., and Hurt M.M. Aurora B Kinase Phosphorylates the Transcription Factor YY1 at G2/M Transition of the Cell Cycle and Modulates its Transcriptional Activity. PLoS ONE. 2012. 7(11): e50645
Riman, S., Rizkallah, R., Kassardjian, A., Alexander, K.E., Lüscher, B., and Hurt, M.M. Phosphorylation of the Transcription Factor YY1 by CK2a Prevents Cleavage by Caspases during Apoptosis. MCB. 2012 Feb 32(4):797-807.
Moseley, S., Rizkallah, R., Tremblay, D.C., Anderson, B., Hurt, M.M., and Chadwick, B.P. YY1 associates with the euchromatic form of DXZ4, and binds with CTCF on the hypomethylated array in some male carcinomas. Nucl. Acids Res. 2012 Feb;40(4):1596-608.
Rizkallah, R., Alexander, K.E., and Hurt, M.M. Global Mitotic Phosphorylation of C2H2 Zinc Finger Protein Linker Peptides. Cell Cycle. 2011 Oct 1;10(19).
Rizkallah, R., Alexander, K.E., Kassardjian, A., Lüscher, B., Hurt, M.M. The Transcription Factor YY1 Is a Substrate for Polo-Like Kinase 1 at the G2/M Transition of the Cell Cycle. PLoS ONE. 2011 Jan 6;6(1):e15928.
Marin, V., Groveman, B.R., Qiao, H., Xu, J., Ali, M.K., Fang, X.Q., Lin, S.X., Rizkallah, R., Hurt, M.M., Bienkiewicz, E.A., Yu, X.M. Characterization of neuronal Src kinase purified from a bacterial expression system. Protein Expr Purif. 2010 Dec;74(2):289-97.
Rizkallah, R., and Hurt, M.M. Regulation of the transcription factor YY1 in mitosis through phosphorylation of its DNA-binding domain. Mol.Biol.Cell. 2009 Nov;20(22):4766-76.
Jin, F., Liu, H., Liang, F., Rizkallah, R., Hurt, M.M., and Wang, Y. Temporal control of the dephosphorylation of Cdk substrates by mitotic exit pathways in budding yeast. Proc. Natl. Acad. Sci. USA. 2008 Oct 21;105(42):16177-82.
Mroueh, M., Saab, Y., and Rizkallah, R. Hepatoprotective activity of Centaurium erythraea on acetaminophen-induced hepatotoxicity in rats. Phytother Res. 2004 May;18(5):431-3.
REVIEW ARTICLES
Rizkallah R.* and Hurt M. The Multilayered Regulation of the Oncogenic Protein YY1. Crit Rev Oncog. 2017;22(1-2):109-129.
BOOK CHAPTERS
Rizkallah, R. (2015) The Multifaceted Roles of YY1 in the Establishment of the Cellular Epigenetic Landscape. In B.P. Chadwick (Ed.): Epigenetics: Current Research and Emerging Trends. U.K. Caister Academic Press.
PATENTS
U.S. Patent No. 8,829,160. Antibody Biomarker Specific for Mitotic Cells and Related Methods. Myra M. Hurt and Raed Rizkallah. September 9, 2014.
U.S. (Divisional) Patent No. 9,261,513 . Antibody Biomarker Specific for Mitotic Cells and Related Methods. Myra M. Hurt and Raed Rizkallah. February 16,2016.
LICENSING
Anti-HpTGEKP polyclonal antibody licensed to EMD Millipore. (http://www.millipore.com/catalogue/item/ABE319)
Mouse hybridoma cell clones producing anti-HpTGEKP monoclonal antibody licensed to BioLegend Inc. (http://www.biolegend.com/purified-anti-c2h2-zinc-finger-protein-phospho-linker-region-hptgekp-antibody-13149.html)
B.S., Biology, American University of Beirut, Beirut, Lebanon.
M.S. Molecular Biology, Lebanese American University, Byblos, Lebanon.
Ph.D., Biological Science, Department of Biological Science, Florida State University.
Postdoctoral, Department of Biomedical Sciences, College of Medicine, Florida State University.
Ad hoc reviewer for the scientific journals:
Scientific Reports
Plos One
Outstanding Achievement as a Postdoctoral Scholar. The Biomedical Sciences Department Award for the year 2011-2012.
Innovator Award, FSU (2012)
Innovator Award, FSU (2011)
American Society for Biochemistry and Molecular Biology (ASBMB)
American Society for Cell Biology (ASCB)
RESEARCH PAPERS
Gutierrez-Morton E, Haluska C, Collins L, Rizkallah R, Tomko RJ Jr, Wang Y. The polySUMOylation axis promotes nucleolar release of Tof2 for mitotic exit. Cell Rep. 2024 Jul 23;43(7):114492.
Daraiseh SI, Kassardjian A, Alexander KE, Rizkallah R, Hurt MM. c-Abl phosphorylation of Yin Yang 1's conserved tyrosine 254 in the spacer region modulates its transcriptional activity. Biochim Biophys Acta. 2018 May 25;1865(9):1173-1186.
Alexander K. and Rizkallah R. Aurora A Phosphorylation of YY1 during Mitosis Inactivates its DNA-Binding Activity. Scientific Reports. 2017. 30;7(1):10084
Rizkallah, R., Batsomboon, P., Dudley, G.B. and Hurt, M. M. Identification of the Oncogenic Kinase TOPK/PBK as a Master Mitotic Regulator of C2H2 Zinc Finger Proteins. Oncotarget. 2015 Jan 30;6(3):1446-61.
Xu, Z., Graham, K., Foote, M., Liang, F., Rizkallah, R., Hurt, M. M., Wang, Y., Wu, Y., & Zhou Y. 14-3-3 targets chaperone-associated misfolded proteins to aggresomes. J Cell Science. 2013. 126, 4173-4186.
Richmond, D., Rizkallah, R., Liang, F., Hurt, MM, and Wang Y. Slk19 clusters kinetochores and facilitates chromosome bipolar attachment. Mol.Biol.Cell. 2013. 24(5), 566-77.
Kassardjian, A., Rizkallah R., Riman S., Renfro S., Alexander K.E., and Hurt M.M. Aurora B Kinase Phosphorylates the Transcription Factor YY1 at G2/M Transition of the Cell Cycle and Modulates its Transcriptional Activity. PLoS ONE. 2012. 7(11): e50645
Riman, S., Rizkallah, R., Kassardjian, A., Alexander, K.E., Lüscher, B., and Hurt, M.M. Phosphorylation of the Transcription Factor YY1 by CK2a Prevents Cleavage by Caspases during Apoptosis. MCB. 2012 Feb 32(4):797-807.
Moseley, S., Rizkallah, R., Tremblay, D.C., Anderson, B., Hurt, M.M., and Chadwick, B.P. YY1 associates with the euchromatic form of DXZ4, and binds with CTCF on the hypomethylated array in some male carcinomas. Nucl. Acids Res. 2012 Feb;40(4):1596-608.
Rizkallah, R., Alexander, K.E., and Hurt, M.M. Global Mitotic Phosphorylation of C2H2 Zinc Finger Protein Linker Peptides. Cell Cycle. 2011 Oct 1;10(19).
Rizkallah, R., Alexander, K.E., Kassardjian, A., Lüscher, B., Hurt, M.M. The Transcription Factor YY1 Is a Substrate for Polo-Like Kinase 1 at the G2/M Transition of the Cell Cycle. PLoS ONE. 2011 Jan 6;6(1):e15928.
Marin, V., Groveman, B.R., Qiao, H., Xu, J., Ali, M.K., Fang, X.Q., Lin, S.X., Rizkallah, R., Hurt, M.M., Bienkiewicz, E.A., Yu, X.M. Characterization of neuronal Src kinase purified from a bacterial expression system. Protein Expr Purif. 2010 Dec;74(2):289-97.
Rizkallah, R., and Hurt, M.M. Regulation of the transcription factor YY1 in mitosis through phosphorylation of its DNA-binding domain. Mol.Biol.Cell. 2009 Nov;20(22):4766-76.
Jin, F., Liu, H., Liang, F., Rizkallah, R., Hurt, M.M., and Wang, Y. Temporal control of the dephosphorylation of Cdk substrates by mitotic exit pathways in budding yeast. Proc. Natl. Acad. Sci. USA. 2008 Oct 21;105(42):16177-82.
Mroueh, M., Saab, Y., and Rizkallah, R. Hepatoprotective activity of Centaurium erythraea on acetaminophen-induced hepatotoxicity in rats. Phytother Res. 2004 May;18(5):431-3.
REVIEW ARTICLES
Rizkallah R.* and Hurt M. The Multilayered Regulation of the Oncogenic Protein YY1. Crit Rev Oncog. 2017;22(1-2):109-129.
BOOK CHAPTERS
Rizkallah, R. (2015) The Multifaceted Roles of YY1 in the Establishment of the Cellular Epigenetic Landscape. In B.P. Chadwick (Ed.): Epigenetics: Current Research and Emerging Trends. U.K. Caister Academic Press.
PATENTS
U.S. Patent No. 8,829,160. Antibody Biomarker Specific for Mitotic Cells and Related Methods. Myra M. Hurt and Raed Rizkallah. September 9, 2014.
U.S. (Divisional) Patent No. 9,261,513 . Antibody Biomarker Specific for Mitotic Cells and Related Methods. Myra M. Hurt and Raed Rizkallah. February 16,2016.
LICENSING
Anti-HpTGEKP polyclonal antibody licensed to EMD Millipore. (http://www.millipore.com/catalogue/item/ABE319)
Mouse hybridoma cell clones producing anti-HpTGEKP monoclonal antibody licensed to BioLegend Inc. (http://www.biolegend.com/purified-anti-c2h2-zinc-finger-protein-phospho-linker-region-hptgekp-antibody-13149.html)