Choogon Lee Ph.D.
Professor
Job Description
Dr. Lee is a professor who is engaged in research in the molecular basis for circadian rhythms and sleep.
Biosketch
Dr. Lee obtained a B.S. from Seoul National University in South Korea. He attended Rutgers University, where he obtained his Ph.D. in microbiology and molecular genetics in 1999.
Education
2000–2003 postdoctoral fellow, UMass Medical School.
1993–1998 Doctoral Degree, Department of Microbiology and Molecular Genetics, Rutgers University.
Service
FSU University Service
Member, FSU Animal Care and Use Committee (2007–2009).
Member, FSU Biosafety Committee (2006–present).
FSU Department Service
Member, Core facility committee (2009–present).
Member, Faculty search committee (2006–2009).
Member, By-Laws and Policy Committee (2006).
The Profession
Reviewer or Panelist for Grant Applications
American Heart Association Grants (2009–present).
The German Isreal Foundation (GIF) (2009).
NIH R01/F31/32 Grants (2006–present).
Ohio Cancer Research Associates (2006).
Honors/Awards
Invited Speaker, International Symposium for Time Studies in Japan (2010).
Invited Speaker, University of Florida (2010).
Outstanding Junior Faculty Researcher, College of Medicine, Florida State University (2009).
Invited Speaker, Scripps Research Institute, Jupiter, FL (2005).
Memberships
Society for Biological Rhythms and Sleep
Society for Neuroscience
Courses
Bioregulation (BMS 6900)
Research Techniques in Biomedical Sciences (BMS5186-C)
Clinical Pharmacology III (PAS 5073)
Pathology 201 (BMS6601)
Medical Microbiology 202 (BMS6302)
Systemic Physiology (BMS 6420)
Special topics in Neurosciences (BMS5935)
Research Focus
The major objective of my research is to understand the molecular basis for our circadian (daily) rhythms including sleep cycles. Circadian rhythms have been observed in nearly all organisms from cyanobacteria to humans. These rhythms are under the direct influence of environmental cues, most notably the day/night cycle, and by a genetically determined, endogenous clock called the “circadian clock.” The most familiar circadian rhythm is our own sleep/wake rhythm. However, there is circadian rhythmicity in many aspects of physiology, including alertness, activity, hormone production and drug efficacy. These and other daily activities and physiological processes are under the control of the circadian clock. The circadian clock is cell-autonomous and ubiquitously present in most tissues.
To understand the molecular mechanism of our circadian rhythms, my lab is using the mouse as a model system. Currently, we are employing diverse molecular techniques including CRISPR to discover novel clock genes and to understand human sleep cycles at a molecular level. The discovery of new clock components and regulatory pathways will not only broaden our understanding of circadian physiology and sleep but also provide additional molecular handles for manipulating the clock for the treatment of human sleep disorders.
To learn more about our research, click the Lee Lab link above.
Publications
Joo HJ, D'Alessandro M, Oh G, Han S, Kim WJ, Chung GE, Jang Y, Lee JB, Lee C*, Yang Y*. Novel targets of β-TrCP cooperatively accelerate carbohydrate and fatty acid consumption. J Cell Physiol. 2023 Aug 16;. doi: 10.1002/jcp.31095. PubMed PMID: 37584358. *co-corresponding authors
Park J, Lee K, Kim H, Shin H, Lee C. Endogenous circadian reporters reveal functional differences of PERIOD paralogs and the significance of PERIOD:CK1 stable interaction. PNAS. 2023 Feb 7;120(6):e2212255120. doi: 10.1073/pnas.2212255120. Epub 2023 Feb 1. PMID: 36724252; PMCID: PMC9962996.2.
Philpott JM, Freeberg AM, Park J, Lee K, Ricci CG, Hunt SR, Narasimamurthy R, Segal DH, Robles R, Cai Y, Tripathi S, McCammon JA, Virshup DM, Chiu JC, Lee C*, Partch CL*. PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol Cell. 2023 May 18;83(10):1677-1692.e8. doi: 10.1016/j.molcel.2023.04.019. PMID: 37207626.
*co-corresponding authors
Lee K, Lee C. Generation of CRISPR-Cas9-mediated knockin mutant models in mice and MEFs for studies of polymorphism in clock genes. Sci Rep. 2023 May 19;13(1):8109. doi: 10.1038/s41598-023- 35203-7. PMID: 37208532; PMCID: PMC10198968.4.
Tice AL, Laudato JA, Rossetti ML, Wolff CA, Esser KA, Lee C, Lang CH, Vied C, Gordon BS, Steiner JL. Binge alcohol disrupts skeletal muscle core molecular clock independent of glucocorticoids. Am J Physiol Endocrinol Metab. 2021 Nov 1;321(5):E606-E620. doi: 10.1152/ajpendo.00187.2021. PubMed PMID: 34541876; PubMed Central PMCID: PMC8791790.
Beasley, S, Kim DW, D’Alessandro, M, Jin, Y1, Lee, K, Joo, H, Young, Y, Tomko, R, Kim, JK, Lee, C. Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis in mice. (2020) PNAS 117 (45): 28402-28411. PubMed Central PMCID: PMC7668169.
Daniel C Levine, Heekyung Hong, Benjamin J Weidemann, Kathryn M Ramsey, Alison H Affinati, Mark S Schmidt, Jonathan Cedernaes, Chiaki Omura, Rosemary Braun, Lee, C., Charles Brenner, Clara Bien Peek, & Joseph Bass. (2020). NAD + Controls Circadian Reprogramming Through PER2 Nuclear Translocation to Counter Aging. Molecular Cell, 78, 1-15. doi:10.1016/j.molcel.2020.04.010
Lee, C. (2019). CRY Arrests Cop1 to Regulate Circadian Rhythms in Mammals. Cell Division, 14, 12-16. doi:10.1186/s13008-019-0055-7
Michael L Rossetti, Karyn A Esser, Lee, C., Robert J Tomko Jr, Alexey M Eroshkin, & Bradley S Gordon. (2019). Disruptions to the Limb Muscle Core Molecular Clock Coincide With Changes in Mitochondrial Quality Control Following Androgen Depletion. Am J Physiol Endocrinol Metab, 317, 631-645. doi:10.1152/ajpendo.00177.2019.
Hiroyuki Shimatani, Masao Doi, Yuta Atobe, Iori Murai, Hida Hayashi, Yukari Takahashi, Jean-Michel Fustin, Yoshiaki Yamaguchi, Hiroshi Kiyonari, Nobuya Koike, Kazuhiro Yagita, Lee, C., Manabu Abe, Kenji Sakimura, & Hitoshi Okamura. (2019). Non-coding Cis-Element of Period2 Is Essential for Maintaining Organismal Circadian Behaviour and Body Temperature Rhythmicity. Nature Communications, 10, 2563. doi:10.1038/s41467-019-10532-2.
Dr. Lee is a professor who is engaged in research in the molecular basis for circadian rhythms and sleep.
Dr. Lee obtained a B.S. from Seoul National University in South Korea. He attended Rutgers University, where he obtained his Ph.D. in microbiology and molecular genetics in 1999.
2000–2003 postdoctoral fellow, UMass Medical School.
1993–1998 Doctoral Degree, Department of Microbiology and Molecular Genetics, Rutgers University.
FSU University Service
Member, FSU Animal Care and Use Committee (2007–2009).
Member, FSU Biosafety Committee (2006–present).
FSU Department Service
Member, Core facility committee (2009–present).
Member, Faculty search committee (2006–2009).
Member, By-Laws and Policy Committee (2006).
The Profession
Reviewer or Panelist for Grant Applications
American Heart Association Grants (2009–present).
The German Isreal Foundation (GIF) (2009).
NIH R01/F31/32 Grants (2006–present).
Ohio Cancer Research Associates (2006).
Invited Speaker, International Symposium for Time Studies in Japan (2010).
Invited Speaker, University of Florida (2010).
Outstanding Junior Faculty Researcher, College of Medicine, Florida State University (2009).
Invited Speaker, Scripps Research Institute, Jupiter, FL (2005).
Society for Biological Rhythms and Sleep
Society for Neuroscience
Bioregulation (BMS 6900)
Research Techniques in Biomedical Sciences (BMS5186-C)
Clinical Pharmacology III (PAS 5073)
Pathology 201 (BMS6601)
Medical Microbiology 202 (BMS6302)
Systemic Physiology (BMS 6420)
Special topics in Neurosciences (BMS5935)
The major objective of my research is to understand the molecular basis for our circadian (daily) rhythms including sleep cycles. Circadian rhythms have been observed in nearly all organisms from cyanobacteria to humans. These rhythms are under the direct influence of environmental cues, most notably the day/night cycle, and by a genetically determined, endogenous clock called the “circadian clock.” The most familiar circadian rhythm is our own sleep/wake rhythm. However, there is circadian rhythmicity in many aspects of physiology, including alertness, activity, hormone production and drug efficacy. These and other daily activities and physiological processes are under the control of the circadian clock. The circadian clock is cell-autonomous and ubiquitously present in most tissues.
To understand the molecular mechanism of our circadian rhythms, my lab is using the mouse as a model system. Currently, we are employing diverse molecular techniques including CRISPR to discover novel clock genes and to understand human sleep cycles at a molecular level. The discovery of new clock components and regulatory pathways will not only broaden our understanding of circadian physiology and sleep but also provide additional molecular handles for manipulating the clock for the treatment of human sleep disorders.
To learn more about our research, click the Lee Lab link above.
Joo HJ, D'Alessandro M, Oh G, Han S, Kim WJ, Chung GE, Jang Y, Lee JB, Lee C*, Yang Y*. Novel targets of β-TrCP cooperatively accelerate carbohydrate and fatty acid consumption. J Cell Physiol. 2023 Aug 16;. doi: 10.1002/jcp.31095. PubMed PMID: 37584358. *co-corresponding authors
Park J, Lee K, Kim H, Shin H, Lee C. Endogenous circadian reporters reveal functional differences of PERIOD paralogs and the significance of PERIOD:CK1 stable interaction. PNAS. 2023 Feb 7;120(6):e2212255120. doi: 10.1073/pnas.2212255120. Epub 2023 Feb 1. PMID: 36724252; PMCID: PMC9962996.2.
Philpott JM, Freeberg AM, Park J, Lee K, Ricci CG, Hunt SR, Narasimamurthy R, Segal DH, Robles R, Cai Y, Tripathi S, McCammon JA, Virshup DM, Chiu JC, Lee C*, Partch CL*. PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol Cell. 2023 May 18;83(10):1677-1692.e8. doi: 10.1016/j.molcel.2023.04.019. PMID: 37207626.
*co-corresponding authors
Lee K, Lee C. Generation of CRISPR-Cas9-mediated knockin mutant models in mice and MEFs for studies of polymorphism in clock genes. Sci Rep. 2023 May 19;13(1):8109. doi: 10.1038/s41598-023- 35203-7. PMID: 37208532; PMCID: PMC10198968.4.
Tice AL, Laudato JA, Rossetti ML, Wolff CA, Esser KA, Lee C, Lang CH, Vied C, Gordon BS, Steiner JL. Binge alcohol disrupts skeletal muscle core molecular clock independent of glucocorticoids. Am J Physiol Endocrinol Metab. 2021 Nov 1;321(5):E606-E620. doi: 10.1152/ajpendo.00187.2021. PubMed PMID: 34541876; PubMed Central PMCID: PMC8791790.
Beasley, S, Kim DW, D’Alessandro, M, Jin, Y1, Lee, K, Joo, H, Young, Y, Tomko, R, Kim, JK, Lee, C. Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis in mice. (2020) PNAS 117 (45): 28402-28411. PubMed Central PMCID: PMC7668169.
Daniel C Levine, Heekyung Hong, Benjamin J Weidemann, Kathryn M Ramsey, Alison H Affinati, Mark S Schmidt, Jonathan Cedernaes, Chiaki Omura, Rosemary Braun, Lee, C., Charles Brenner, Clara Bien Peek, & Joseph Bass. (2020). NAD + Controls Circadian Reprogramming Through PER2 Nuclear Translocation to Counter Aging. Molecular Cell, 78, 1-15. doi:10.1016/j.molcel.2020.04.010
Lee, C. (2019). CRY Arrests Cop1 to Regulate Circadian Rhythms in Mammals. Cell Division, 14, 12-16. doi:10.1186/s13008-019-0055-7
Michael L Rossetti, Karyn A Esser, Lee, C., Robert J Tomko Jr, Alexey M Eroshkin, & Bradley S Gordon. (2019). Disruptions to the Limb Muscle Core Molecular Clock Coincide With Changes in Mitochondrial Quality Control Following Androgen Depletion. Am J Physiol Endocrinol Metab, 317, 631-645. doi:10.1152/ajpendo.00177.2019.
Hiroyuki Shimatani, Masao Doi, Yuta Atobe, Iori Murai, Hida Hayashi, Yukari Takahashi, Jean-Michel Fustin, Yoshiaki Yamaguchi, Hiroshi Kiyonari, Nobuya Koike, Kazuhiro Yagita, Lee, C., Manabu Abe, Kenji Sakimura, & Hitoshi Okamura. (2019). Non-coding Cis-Element of Period2 Is Essential for Maintaining Organismal Circadian Behaviour and Body Temperature Rhythmicity. Nature Communications, 10, 2563. doi:10.1038/s41467-019-10532-2.