Job Description
Dr. Zhou is a scientist who is conducting his research in the area of molecular and cellular neurosciences. He also teaches courses for graduate and Physician Assistant students.
Biosketch
Dr. Zhou comes to the FSU College of Medicine from the College of Medicine, University of Alabama at Birmingham, where he was an assistant professor from 2003 to 2007. He obtained his Ph.D. from University of Minnesota, and carried out postdoctoral research at Brandeis University.
Education
1995 Doctor of Philosophy, University Of Minnesota Twin C. Major: Biological Sciences.
1987 M.S. Physiology, Peking University: China. Major: Physiology.
1984 B.S. Biology, Peking University: China. Major: Biology.
Postdegree Education and Training
1995–1999 Post Doctoral training in Neurosicences, Brandeis University, Waltham, MA.
Service
FSU University Service
FSU Faculty Senate
FSU Department Service
Chair, Space Committee
Member, Graduate Committee
Member, Faculty Eealuation Committee
Member, By-law and policy committee
The Profession
Editor for Refereed Journals
Global Journal of Biotechnology, Senior Editor (2010–present).
Editorial Board Membership(s)
International Journal of Biochemistry and Molecular Biology (2011–present).
Frontier in Neuroscience (2017 - present)
Annals of Neuropsychiatry (2018–present).
JSM Schizophrenia (2016–present).
Journal of Neurology and Therapy (2015–present).
International Journal of Psychological and Brain Sciences (2019–2021).
Guest Reviewer for Refereed Journals
Molecular and Cellular Neurosciences (2008–present).
Journal of Cell Science (2007–present).
Cell Proliferation (2007–present).
PNAS (2006–present).
Neuropharmacology (2005–present).
Reviewer or Panelist for Grant Applications
National Science Foundation (2006–present).
National Institutes of Health (2004–present).
Honors/Awards
July 2024 - July 2025
Florida Department of Health
Study developmental and epileptic encephalopathy using YWHAG mutation models
Sep 2017–Jun 2023 (R01MH115188)
NIH (NIMH)
Molecular, synaptic and circuit basis for 14-3-3 dysfunction-induced behavioral deficits
Outstanding Senior Faculty Researcher, College of Medicine, FSU (2010).
Sept. 2007 -Aug. 2012 (1R01NS050355-01)
NIH (NINDS)
Functions of the N-Type Ca Channel/14-3-3 Interaction
Aug. 2006 - July 2010 (0635497N)
American Heart Association
Regulation of Neurotransmissions in Sympathetic Neurons: Function of the 14-3-3/Ca Channel Interaction
2005 FRET Microscopy Workshop award
Cell Adhesion and Matrix Research Center, UAB
1995 Lifson/Johnson Memorial Award
Minnesota Medical Foundation
1994 Allan Hemingway Endowed Scholarship
Minnesota Medical Foundation
1994 Doctoral Dissertation Special Grant,
Graduate School, University of Minnesota
Memberships
Society for Neuroscience.
American Association for Advancement of Science.
American Society for Cell Biology
Schizophrenia International Research Society
Courses
Insights into human congenital and developmental disorders
Research Techniques
Bioregulation
RNA Silencing and disease
PA Clinical Pharmacology I
PA Clinical Pharmacology III
Research Focus
Molecular and Cellular Basis of Neurodegenerative Diseases
Animal Models of Neuropsychiatric Disease
Functions and Regulation of Neuronal Ion Channels
Publications
Logue, J., Bodycot, V., Zhang, J., Wu, Y., & Zhou, Y. (2024). Inhibition of 14-3-3 proteins increases the intrinsic excitability of mouse hippocampal CA1 pyramidal neurons. European Journal of Neuroscience, Jun;59(12):3309-332
Navarrete, M., & Zhou, Y. (2022). The 14-3-3 protein family and Schizophrenia. Frontiers in Molecular neuroscience, 12.
Zhang, J., Navarrete, M., Wu, Y., & Zhou, Y. (2022). 14-3-3 Dysfunction in Dorsal Hippocampus CA1 (dCA1) Induces Psychomotor Behavior via a dCA1-Lateral Septum-Ventral Tegmental Area Pathway. Frontiers in Molecular Neuroscience, 16. Retrieved from http://dx.doi.org/10.3389/fnmol.2022.817227 doi:10.3389/fnmol.2022.817227
Lee, G., Zhang, J., Wu, Y., & Zhou, Y. (2021). 14-3-3 proteins promote synaptic localization of N-methyl d-aspartate receptors (NMDARs) in mouse hippocampal and cortical neurons. Plos One, 21.
Jones, Z., Zhang, J., Wu, Y., & Zhou, Y. (2021). Inhibition of 14-3-3 proteins alters neural oscillations in mice. Frontiers in Neural Circuits.
Huang, D., Liu, H., Zhou, Y., & Li, Y. (2020). Forebrain Excitatory Neuron-Specific SENP2 Knockout Mouse Displays Hyperactivity, Impaired Learning and Memory, and Anxiolytic-Like Behavior. Molecular Brain, 13(1):59, 20. doi:10.1186/s13041-020-00591-8
Lee, G., & Zhou, Y. (2019). Animal Models of NMDAR Hypofunction for Schizophrenia. Frontier in Molecular Neuroscience, 12, 26. doi:10.3389/fnmol.2019.00185
Song, L., Yuan, X., Jones, Z., Griffin, K., Zhou, Y., Ma, T., & Li, Y. (2019). Assembly of Human Stem Cell-Derived Cortical Spheroids and Vascular Spheroids to Model 3-D Brain-like Tissues. Scientific Report, 9(1), 20. doi:10.1038/s41598-019-42439-9
Song, L., Yuan, X., Zachary, J., Vied, C., Guan, J., Zhou, Y., & Li, Y. (2019). Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells. Scientific Reports, 9(1), 22. doi:10.1186/s13041-020-00591-8
Graham, K., Zhang, J., Qiao, H., Wu, Y., & Zhou, Y. (2019). Region-Specific Inhibition of 14-3-3 Proteins Induces Psychomotor Behaviors in Mice. NJP Schizophrenia, 14;5(1), 24. doi:10.1038/s41537-018-0069-1
Bejoy, J., Song, L., Wang, Z., Sang, Q., Zhou, Y., & Li, Y. (2018). Neuroprotective Activities of Heparin, Heparinase III, and Hyaluronic Acid on the Aβ42-treated Forebrain Spheroids Derived from Human Stem Cells. ACS Biomaterials Science & Engineering, 24.
Wang, Y., Wang, Y., Sun, H., Zhou, A., Zhou, Y., & Li, Y. (2016). Sequential posttranslational modifications regulate PKC degradation. Molecular Biology of Cell, 27(2), 410-20.
Foote, M., Qiao, H., Graham, K., Wu, Y., & Zhou, Y. (2015). Inhibition of 14-3-3 Proteins Leads to Schizophrenia-Related Behavioral Phenotypes and Synaptic Defects in Mice. Biological Psychiatry, 78(6), 386-95.
Liu F, Zhou Q, Zhou J, Sun H, Wang Y, Zou X, Feng L, Hou Z, Zhou A, Zhou Y, Li Y. (2015) 14-3-3t Promotes Surface Expression of Cav2.2 (a1B) Ca2+ Channels. J Biol Chem. 290(5):2689-98.
Qiao H, Foote M, Graham K, Wu Y, Zhou Y. (2014) 14-3-3 proteins are required for hippocampal long-term potentiation and associative learning and memory. J Neurosci. 34(14):4801-8.
Jia B, Wu Y, Zhou Y. (2014) 14-3-3 and aggresome formation: implications in neurodegenerative diseases. Prion. Mar-Apr;8(2).
Xu Z, Graham K, Foote M, Liang F, Rizkallah R, Hurt M, Wang Y, Wu Y, Zhou Y. (2013) 14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes. J Cell Sci. 126(Pt 18):4173-86.
Sun C, Qiao H, Zhou Q, Wang Y, Wu Y, Zhou Y., Li Y. (2013) Modulation of GluK2a subunit-containing kainate receptors by 14-3-3 proteins. J Biol Chem. 288(34):24676-90.
Zhou Y, Zhao M, Fields GB, Wu CF, Branton WD. (2013) d/?-Plectoxin-Pt1a: an excitatory spider toxin with actions on both Ca(2+) and Na(+) channels. PLoS One. 8(5):e64324.
Gao X, Qiao Y, Jia B, Jing X, Cheng B, Wen L, Tan Q, Zhou Y, Zhu B, Qiao H. (2012) NMDA Receptor-Dependent Synaptic Activity in Dorsal Motor Nucleus of Vagus Mediates the Enhancement of Gastric Motility by Stimulating ST36. Evid Based Complement Alternat Med. 2012:438460.
Foote M, Zhou Y. (2012) 14-3-3 proteins in neurological disorders. Int J Biochem Mol Biol. 3(2):152-64.
Huang, Z., Xu, Z., Wu, Y., & Zhou, Y. (2011). Determining nuclear localization of alpha-synuclein in mouse brains. Neuroscience, 199, 318-332.
Li, Y., Liu, X., Wu, Y., Xu, Z., Li, H., Griffith, L., & Zhou, Y. (2011). Intracellular regions of the eag potassium channel play a critical role in generation of voltage-dependent currents. Journal of Biological Chemistry, 286(2), 1389-99.
Liu, X., Wu, Y., & Zhou, Y. (2010). Intracellular linkers are involved in Mg2+-dependent modulation of the Eag potassium channel. Channels, 4(4), 311-318.
Lu, R., Li, Y., Zhang, Y., Chen, Y., Shields, A. D., Winder, D. G., Angelotti, T., Jiao, K., Limbird, L. E., Zhou, Y., & Wang, Q. (2009). Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is due to ligand-selective internalization. Journal of Biological Chemistry, 284(19), 13233-43. *co-first authors.
Li ,Y., Wu, Y. and Zhou, Y. Modulation of Inactivation Properties of Cav2.2 Channels by 14-3-3 Proteins. (2006) Neuron 51:755–771.
Lai, M., Wang, F., Rohan, J.G., Maeno-Hikichi, Y., Chen, Y., Zhou, Y., Gao, G., Sather,W.A., Zhang, J.F. (2005) A tctex1-Ca(2+) channel complex for selective surface expression of Ca(2+) channels in neurons. Nat Neurosci., 8:435-442.
Dr. Zhou is a scientist who is conducting his research in the area of molecular and cellular neurosciences. He also teaches courses for graduate and Physician Assistant students.
Dr. Zhou comes to the FSU College of Medicine from the College of Medicine, University of Alabama at Birmingham, where he was an assistant professor from 2003 to 2007. He obtained his Ph.D. from University of Minnesota, and carried out postdoctoral research at Brandeis University.
1995 Doctor of Philosophy, University Of Minnesota Twin C. Major: Biological Sciences.
1987 M.S. Physiology, Peking University: China. Major: Physiology.
1984 B.S. Biology, Peking University: China. Major: Biology.
Postdegree Education and Training
1995–1999 Post Doctoral training in Neurosicences, Brandeis University, Waltham, MA.
FSU University Service
FSU Faculty Senate
FSU Department Service
Chair, Space Committee
Member, Graduate Committee
Member, Faculty Eealuation Committee
Member, By-law and policy committee
The Profession
Editor for Refereed Journals
Global Journal of Biotechnology, Senior Editor (2010–present).
Editorial Board Membership(s)
International Journal of Biochemistry and Molecular Biology (2011–present).
Frontier in Neuroscience (2017 - present)
Annals of Neuropsychiatry (2018–present).
JSM Schizophrenia (2016–present).
Journal of Neurology and Therapy (2015–present).
International Journal of Psychological and Brain Sciences (2019–2021).
Guest Reviewer for Refereed Journals
Molecular and Cellular Neurosciences (2008–present).
Journal of Cell Science (2007–present).
Cell Proliferation (2007–present).
PNAS (2006–present).
Neuropharmacology (2005–present).
Reviewer or Panelist for Grant Applications
National Science Foundation (2006–present).
National Institutes of Health (2004–present).
July 2024 - July 2025
Florida Department of Health
Study developmental and epileptic encephalopathy using YWHAG mutation models
Sep 2017–Jun 2023 (R01MH115188)
NIH (NIMH)
Molecular, synaptic and circuit basis for 14-3-3 dysfunction-induced behavioral deficits
Outstanding Senior Faculty Researcher, College of Medicine, FSU (2010).
Sept. 2007 -Aug. 2012 (1R01NS050355-01)
NIH (NINDS)
Functions of the N-Type Ca Channel/14-3-3 Interaction
Aug. 2006 - July 2010 (0635497N)
American Heart Association
Regulation of Neurotransmissions in Sympathetic Neurons: Function of the 14-3-3/Ca Channel Interaction
2005 FRET Microscopy Workshop award
Cell Adhesion and Matrix Research Center, UAB
1995 Lifson/Johnson Memorial Award
Minnesota Medical Foundation
1994 Allan Hemingway Endowed Scholarship
Minnesota Medical Foundation
1994 Doctoral Dissertation Special Grant,
Graduate School, University of Minnesota
Society for Neuroscience.
American Association for Advancement of Science.
American Society for Cell Biology
Schizophrenia International Research Society
Insights into human congenital and developmental disorders
Research Techniques
Bioregulation
RNA Silencing and disease
PA Clinical Pharmacology I
PA Clinical Pharmacology III
Molecular and Cellular Basis of Neurodegenerative Diseases
Animal Models of Neuropsychiatric Disease
Functions and Regulation of Neuronal Ion Channels
Logue, J., Bodycot, V., Zhang, J., Wu, Y., & Zhou, Y. (2024). Inhibition of 14-3-3 proteins increases the intrinsic excitability of mouse hippocampal CA1 pyramidal neurons. European Journal of Neuroscience, Jun;59(12):3309-332
Navarrete, M., & Zhou, Y. (2022). The 14-3-3 protein family and Schizophrenia. Frontiers in Molecular neuroscience, 12.
Zhang, J., Navarrete, M., Wu, Y., & Zhou, Y. (2022). 14-3-3 Dysfunction in Dorsal Hippocampus CA1 (dCA1) Induces Psychomotor Behavior via a dCA1-Lateral Septum-Ventral Tegmental Area Pathway. Frontiers in Molecular Neuroscience, 16. Retrieved from http://dx.doi.org/10.3389/fnmol.2022.817227 doi:10.3389/fnmol.2022.817227
Lee, G., Zhang, J., Wu, Y., & Zhou, Y. (2021). 14-3-3 proteins promote synaptic localization of N-methyl d-aspartate receptors (NMDARs) in mouse hippocampal and cortical neurons. Plos One, 21.
Jones, Z., Zhang, J., Wu, Y., & Zhou, Y. (2021). Inhibition of 14-3-3 proteins alters neural oscillations in mice. Frontiers in Neural Circuits.
Huang, D., Liu, H., Zhou, Y., & Li, Y. (2020). Forebrain Excitatory Neuron-Specific SENP2 Knockout Mouse Displays Hyperactivity, Impaired Learning and Memory, and Anxiolytic-Like Behavior. Molecular Brain, 13(1):59, 20. doi:10.1186/s13041-020-00591-8
Lee, G., & Zhou, Y. (2019). Animal Models of NMDAR Hypofunction for Schizophrenia. Frontier in Molecular Neuroscience, 12, 26. doi:10.3389/fnmol.2019.00185
Song, L., Yuan, X., Jones, Z., Griffin, K., Zhou, Y., Ma, T., & Li, Y. (2019). Assembly of Human Stem Cell-Derived Cortical Spheroids and Vascular Spheroids to Model 3-D Brain-like Tissues. Scientific Report, 9(1), 20. doi:10.1038/s41598-019-42439-9
Song, L., Yuan, X., Zachary, J., Vied, C., Guan, J., Zhou, Y., & Li, Y. (2019). Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells. Scientific Reports, 9(1), 22. doi:10.1186/s13041-020-00591-8
Graham, K., Zhang, J., Qiao, H., Wu, Y., & Zhou, Y. (2019). Region-Specific Inhibition of 14-3-3 Proteins Induces Psychomotor Behaviors in Mice. NJP Schizophrenia, 14;5(1), 24. doi:10.1038/s41537-018-0069-1
Bejoy, J., Song, L., Wang, Z., Sang, Q., Zhou, Y., & Li, Y. (2018). Neuroprotective Activities of Heparin, Heparinase III, and Hyaluronic Acid on the Aβ42-treated Forebrain Spheroids Derived from Human Stem Cells. ACS Biomaterials Science & Engineering, 24.
Wang, Y., Wang, Y., Sun, H., Zhou, A., Zhou, Y., & Li, Y. (2016). Sequential posttranslational modifications regulate PKC degradation. Molecular Biology of Cell, 27(2), 410-20.
Foote, M., Qiao, H., Graham, K., Wu, Y., & Zhou, Y. (2015). Inhibition of 14-3-3 Proteins Leads to Schizophrenia-Related Behavioral Phenotypes and Synaptic Defects in Mice. Biological Psychiatry, 78(6), 386-95.
Liu F, Zhou Q, Zhou J, Sun H, Wang Y, Zou X, Feng L, Hou Z, Zhou A, Zhou Y, Li Y. (2015) 14-3-3t Promotes Surface Expression of Cav2.2 (a1B) Ca2+ Channels. J Biol Chem. 290(5):2689-98.
Qiao H, Foote M, Graham K, Wu Y, Zhou Y. (2014) 14-3-3 proteins are required for hippocampal long-term potentiation and associative learning and memory. J Neurosci. 34(14):4801-8.
Jia B, Wu Y, Zhou Y. (2014) 14-3-3 and aggresome formation: implications in neurodegenerative diseases. Prion. Mar-Apr;8(2).
Xu Z, Graham K, Foote M, Liang F, Rizkallah R, Hurt M, Wang Y, Wu Y, Zhou Y. (2013) 14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes. J Cell Sci. 126(Pt 18):4173-86.
Sun C, Qiao H, Zhou Q, Wang Y, Wu Y, Zhou Y., Li Y. (2013) Modulation of GluK2a subunit-containing kainate receptors by 14-3-3 proteins. J Biol Chem. 288(34):24676-90.
Zhou Y, Zhao M, Fields GB, Wu CF, Branton WD. (2013) d/?-Plectoxin-Pt1a: an excitatory spider toxin with actions on both Ca(2+) and Na(+) channels. PLoS One. 8(5):e64324.
Gao X, Qiao Y, Jia B, Jing X, Cheng B, Wen L, Tan Q, Zhou Y, Zhu B, Qiao H. (2012) NMDA Receptor-Dependent Synaptic Activity in Dorsal Motor Nucleus of Vagus Mediates the Enhancement of Gastric Motility by Stimulating ST36. Evid Based Complement Alternat Med. 2012:438460.
Foote M, Zhou Y. (2012) 14-3-3 proteins in neurological disorders. Int J Biochem Mol Biol. 3(2):152-64.
Huang, Z., Xu, Z., Wu, Y., & Zhou, Y. (2011). Determining nuclear localization of alpha-synuclein in mouse brains. Neuroscience, 199, 318-332.
Li, Y., Liu, X., Wu, Y., Xu, Z., Li, H., Griffith, L., & Zhou, Y. (2011). Intracellular regions of the eag potassium channel play a critical role in generation of voltage-dependent currents. Journal of Biological Chemistry, 286(2), 1389-99.
Liu, X., Wu, Y., & Zhou, Y. (2010). Intracellular linkers are involved in Mg2+-dependent modulation of the Eag potassium channel. Channels, 4(4), 311-318.
Lu, R., Li, Y., Zhang, Y., Chen, Y., Shields, A. D., Winder, D. G., Angelotti, T., Jiao, K., Limbird, L. E., Zhou, Y., & Wang, Q. (2009). Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is due to ligand-selective internalization. Journal of Biological Chemistry, 284(19), 13233-43. *co-first authors.
Li ,Y., Wu, Y. and Zhou, Y. Modulation of Inactivation Properties of Cav2.2 Channels by 14-3-3 Proteins. (2006) Neuron 51:755–771.
Lai, M., Wang, F., Rohan, J.G., Maeno-Hikichi, Y., Chen, Y., Zhou, Y., Gao, G., Sather,W.A., Zhang, J.F. (2005) A tctex1-Ca(2+) channel complex for selective surface expression of Ca(2+) channels in neurons. Nat Neurosci., 8:435-442.