Cynthia Vied Ph.D.
Associate in Research
Job Description
Cynthia (Cindy) Vied is involved in implementation of Next-Generation sequencing and Mass Spectrometry services. She is responsible for the pipeline upstream and downstream of NovaSeq workflows. She has extensive experience in Next-Generation Sequencing sample prep and data analysis and provides consultation regarding project scope, design and implementation, as well as data analysis.
Education
Research assistant, Columbia University, Department of Biological Sciences.
Postdoctoral Research, Columbia University, Department of Biological Sciences.
Ph.D., Biochemistry and Molecular Genetics. University of Alabama at Birmingham.
B.S., Biological Sciences, Murray State University.
Research Focus
Graduate research: Investigation of the regulation of Sex-lethal, the sex determination master switch in Drosophila melanogaster.
Postdoctoral Researcher: Hedgehog signal transduction pathway regulation of stem cells.
2010-2016, Research Faculty, Department of Biomedical Sciences, FSU College of Medicine: Using genomic approaches to evaluate sex differences in the mouse brain.
2016-Current, Associate in Research, Translational Science Laboratory, FSU College of Medicine: Next Generation Sequencing and Mass Spectrometry.
Publications
Jones, S.K., McCarthy, D.M., Vied, C., Stanwood, G.D., Schatschneider, C., Bhide, P.G. (2022). Transgenerational transmission of aspartame-induced anxiety and changes in glutamate-GABA signaling and gene expression in the amygdala. Proc Natl Acad Sci U S A. Dec 6;119(49).
Dunlap, K.R., Laskin, G.R., Waddell, D.S., Black, A.J., Steiner, J.L., Vied, C., Gordon, B.S. (2022). Aerobic exercise-mediated changes in the expression of glucocorticoid responsive genes in skeletal muscle differ across the day. Mol Cell Endocrinol. 2022 Apr 21; 550:111652.
Gill, W.D., Burgess, K.C., Vied, C., & Brown, R.W. (2021). Transgenerational evidence of increases in dopamine D2 receptor sensitivity in rodents: Impact on sensorimotor gating, the behavioral response to nicotine and BDNF. J Psychopharmacol. 2021 Oct;35(10).
Tice, A.L., Laudato, J.A., Rossetti, M.L., Wolff, C.A., Esser, K.A., Lee, C., Lang, C.H., Vied, C., Gordon, B.S., Steiner, J.L. (2021). Binge alcohol disrupts skeletal muscle core molecular clock independent of glucocorticoids. Am J Physiol Endocrinol Metab. 2021 Nov 1;321(5): E606-E620.
Dieseldorff Jones, K.M., Vied, C., Valera, I.C., Chase, P.B., Parvatiyar, M.S., & Pinto, J.R. (2020). Sexual dimorphism in cardiac transcriptome associated with a troponin C murine model of hypertrophic cardiomyopathy. Physiol Reports, Mar;8(6): e14396.
Song, L., Yuan, X., Jones, Z., Vied, C., Miao, Y., Marzano, M., Hua, T., Sang, Q., Guan, J., Ma, T., Zhou, Y., & Li, Y. (2019). Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells. Scientific Reports, 9(1), 11055.
DiCarlo, L.M., Vied, C. and Nowakowski, R.S. (2017). The Stability of the Transcriptome during the Estrous Cycle in Four Regions of the Mouse Brain. Journal of Comparative Neurology, 525(15) 3360-3387. doi: 10.1002/cne.24282
Bundy, J.L., Vied, C. and Nowakowski, R.S. (2017). Sex differences in the molecular signature of the developing mouse hippocampus. BMC Genomics, 18(1), 1-17. doi:10.1186/s12864-017-3608-7.
Darkazalli, A.*, Vied, C.*, Badger, C. and Levenson, C. (2017). Human Mesenchymal Stem Cell Treatment Normalizes Cortical Gene Expression after Traumatic Brain Injury. Journal of Neurotrauma, 34(1) 204-212. doi:10.1089/neu.2015.4322.
Vied, C., Ray, S., Badger, C., Bundy, J., Arbeitman, M.N. and Nowakowski, R.S. (2016). Transcriptomic Analysis of the Hippocampus from Six Inbred Strains of Mice Suggests Basis for Sex-Specific Susceptibility and Severity of Neurological Disorders. Journal of Comparative Neurology, 524(13) 2696-2710. doi: 10.1002/cne.23989.
Ray, S., Tzeng, R.Y., DiCarlo, L.M., Bundy, J.L., Vied, C., Tyson, G., Nowakowski, R.S. and Arbeitman, M.N. (2015). An Examination of Dynamic Gene Expression Changes in the Mouse Brain During Pregnancy and the Postpartum Period. G3, 6(1) 221-233. doi:10.1002/cne.23989.
Brown, A.N.*, Vied, C.*, Dennis, J. H. and Bhide, B.G. (2015). Nucleosome Repositioning: A Novel Mechanism for Nicotine- and Cocaine-induced Epigenetic Changes. PLoS One, 10(9) e0139103. doi:10.1371/journal.pone.0139103.
Vied, C., Freudenberg, F., Wang, Y., Raposo, A.A., Feng, D. and Nowakowski, R.S. (2014). A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development. Frontiers in Neuroscience, 21(8) 257. doi:10.3389/fnins.2014.00257.
Vied, C., Reilein, A., Field, N.S. and Kalderon, D. (2012). Regulation of stem cells by intersecting gradients of long-range niche signals. Developmental Cell, 23(4) 836-848. doi:10.1016/j.devcel.2012.09.010.
Vied, C., & Kalderon, D. (2009). Hedgehog-stimulated Stem Cells Depend on Non-Canonical Activity of the Notch Co-activator Mastermind. Development, 136(13), 2177-2186.
Horabin, J., Walthall, S., Vied, C., & Moses, M. (2003). A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch. Development, 130(24), 6101-6109.
Vied, C., Halachmi, N., Salzberg, A., & Horabin, J. I. (2003). Antizyme is a target of Sex-lethal in the Drosophila germline and appears to act downstream of Hedgehog to regulate Sex-lethal and Cyclin B. Developmental Biology, 253(2), 214-229.
Vied, C., & Horabin, J. I. (2001). The Sex Determination Master Switch, Sex-lethal, Responds to Hedgehog Signaling in the Drosophila Germline. Development, 128, 2649-2660.
*Contributed Equally to this Work.
Cynthia (Cindy) Vied is involved in implementation of Next-Generation sequencing and Mass Spectrometry services. She is responsible for the pipeline upstream and downstream of NovaSeq workflows. She has extensive experience in Next-Generation Sequencing sample prep and data analysis and provides consultation regarding project scope, design and implementation, as well as data analysis.
Research assistant, Columbia University, Department of Biological Sciences.
Postdoctoral Research, Columbia University, Department of Biological Sciences.
Ph.D., Biochemistry and Molecular Genetics. University of Alabama at Birmingham.
B.S., Biological Sciences, Murray State University.
Graduate research: Investigation of the regulation of Sex-lethal, the sex determination master switch in Drosophila melanogaster.
Postdoctoral Researcher: Hedgehog signal transduction pathway regulation of stem cells.
2010-2016, Research Faculty, Department of Biomedical Sciences, FSU College of Medicine: Using genomic approaches to evaluate sex differences in the mouse brain.
2016-Current, Associate in Research, Translational Science Laboratory, FSU College of Medicine: Next Generation Sequencing and Mass Spectrometry.
Jones, S.K., McCarthy, D.M., Vied, C., Stanwood, G.D., Schatschneider, C., Bhide, P.G. (2022). Transgenerational transmission of aspartame-induced anxiety and changes in glutamate-GABA signaling and gene expression in the amygdala. Proc Natl Acad Sci U S A. Dec 6;119(49).
Dunlap, K.R., Laskin, G.R., Waddell, D.S., Black, A.J., Steiner, J.L., Vied, C., Gordon, B.S. (2022). Aerobic exercise-mediated changes in the expression of glucocorticoid responsive genes in skeletal muscle differ across the day. Mol Cell Endocrinol. 2022 Apr 21; 550:111652.
Gill, W.D., Burgess, K.C., Vied, C., & Brown, R.W. (2021). Transgenerational evidence of increases in dopamine D2 receptor sensitivity in rodents: Impact on sensorimotor gating, the behavioral response to nicotine and BDNF. J Psychopharmacol. 2021 Oct;35(10).
Tice, A.L., Laudato, J.A., Rossetti, M.L., Wolff, C.A., Esser, K.A., Lee, C., Lang, C.H., Vied, C., Gordon, B.S., Steiner, J.L. (2021). Binge alcohol disrupts skeletal muscle core molecular clock independent of glucocorticoids. Am J Physiol Endocrinol Metab. 2021 Nov 1;321(5): E606-E620.
Dieseldorff Jones, K.M., Vied, C., Valera, I.C., Chase, P.B., Parvatiyar, M.S., & Pinto, J.R. (2020). Sexual dimorphism in cardiac transcriptome associated with a troponin C murine model of hypertrophic cardiomyopathy. Physiol Reports, Mar;8(6): e14396.
Song, L., Yuan, X., Jones, Z., Vied, C., Miao, Y., Marzano, M., Hua, T., Sang, Q., Guan, J., Ma, T., Zhou, Y., & Li, Y. (2019). Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells. Scientific Reports, 9(1), 11055.
DiCarlo, L.M., Vied, C. and Nowakowski, R.S. (2017). The Stability of the Transcriptome during the Estrous Cycle in Four Regions of the Mouse Brain. Journal of Comparative Neurology, 525(15) 3360-3387. doi: 10.1002/cne.24282
Bundy, J.L., Vied, C. and Nowakowski, R.S. (2017). Sex differences in the molecular signature of the developing mouse hippocampus. BMC Genomics, 18(1), 1-17. doi:10.1186/s12864-017-3608-7.
Darkazalli, A.*, Vied, C.*, Badger, C. and Levenson, C. (2017). Human Mesenchymal Stem Cell Treatment Normalizes Cortical Gene Expression after Traumatic Brain Injury. Journal of Neurotrauma, 34(1) 204-212. doi:10.1089/neu.2015.4322.
Vied, C., Ray, S., Badger, C., Bundy, J., Arbeitman, M.N. and Nowakowski, R.S. (2016). Transcriptomic Analysis of the Hippocampus from Six Inbred Strains of Mice Suggests Basis for Sex-Specific Susceptibility and Severity of Neurological Disorders. Journal of Comparative Neurology, 524(13) 2696-2710. doi: 10.1002/cne.23989.
Ray, S., Tzeng, R.Y., DiCarlo, L.M., Bundy, J.L., Vied, C., Tyson, G., Nowakowski, R.S. and Arbeitman, M.N. (2015). An Examination of Dynamic Gene Expression Changes in the Mouse Brain During Pregnancy and the Postpartum Period. G3, 6(1) 221-233. doi:10.1002/cne.23989.
Brown, A.N.*, Vied, C.*, Dennis, J. H. and Bhide, B.G. (2015). Nucleosome Repositioning: A Novel Mechanism for Nicotine- and Cocaine-induced Epigenetic Changes. PLoS One, 10(9) e0139103. doi:10.1371/journal.pone.0139103.
Vied, C., Freudenberg, F., Wang, Y., Raposo, A.A., Feng, D. and Nowakowski, R.S. (2014). A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development. Frontiers in Neuroscience, 21(8) 257. doi:10.3389/fnins.2014.00257.
Vied, C., Reilein, A., Field, N.S. and Kalderon, D. (2012). Regulation of stem cells by intersecting gradients of long-range niche signals. Developmental Cell, 23(4) 836-848. doi:10.1016/j.devcel.2012.09.010.
Vied, C., & Kalderon, D. (2009). Hedgehog-stimulated Stem Cells Depend on Non-Canonical Activity of the Notch Co-activator Mastermind. Development, 136(13), 2177-2186.
Horabin, J., Walthall, S., Vied, C., & Moses, M. (2003). A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch. Development, 130(24), 6101-6109.
Vied, C., Halachmi, N., Salzberg, A., & Horabin, J. I. (2003). Antizyme is a target of Sex-lethal in the Drosophila germline and appears to act downstream of Hedgehog to regulate Sex-lethal and Cyclin B. Developmental Biology, 253(2), 214-229.
Vied, C., & Horabin, J. I. (2001). The Sex Determination Master Switch, Sex-lethal, Responds to Hedgehog Signaling in the Drosophila Germline. Development, 128, 2649-2660.
*Contributed Equally to this Work.