Biosketch
Dr. Jose R. Pinto earned his Ph.D in 2006 from the Federal University of Rio de Janeiro. His research of study is Muscle Biochemistry and Biophysics. He researched as a postdoctoral scholar from 2006 to 2010 at the University of Miami, Miller School of Medicine under the mentoring of Dr. James D. Potter. His postdoctoral research focus was on the Molecular Mechanisms of Inherited Cardiomyopathies. In 2010, Dr. Pinto became a research assistant professor until he joined the FSU College of Medicine Biomedical Sciences Department in 2011. Dr. Pinto was promoted to Associate Professor with Tenure in 2017 and then to Full Professor in 2023.
CURRENTLY ACCEPTING NEW GRADUATE STUDENTS
Education
Ph.D. in Medical Biochemistry (2006), Federal University of Rio de Janeiro - Brazil
Postdoctoral training (2006 - 2010), University of Miami, Miller School of Medicine - USA
Service
Editorial Board:
Associate Editor: Scientific Reports, IJMS, BBR & Frontiers in Physiology
Editorial Board: BBA Gen Subjects & ABB
Peer Review responsibilities:
2022 - NIH MPPA Standing Member
2021 - NIH MPPA
2021 - VA CARA
2020 - NIH F10A-R (20) L ZRG1
2020 - NIH MIM
2020 – AHA TPA Cardiac Basic Sciences
2019 – NIH F10-A-R (20) L ZRG1
2019 – NIH CCHF (ad hoc)
2019 – NIH consultant – Member of a PPG committee
2017 – Wellcome Trust, UK
2017 – Prinses Beatrix Spierfonds, The Netherlands
2016-2017 – NIH ZRG1 MOSS D(82)
2016 – AHA, Strategically Focused Research Network – Heart Failure
2014 - present – FSU - CRC-COFRS grant review
2014 - Netherlands Organisation for Scientific Research (NWO)
Jan/2013 – NIH consultant – Member of a PPG committee.
2012 - present - American Heart Association. Member of the Cardiac Biology Basic Science 4 committee.
At Florida State University
2023-present Promotion and Tenure Committee, Dept. Biomedical Sciences, College of Medicine, FSU
2023-present Faculty Council Executive Committee, College of Medicine, FSU
2020-present Graduate Program Committee, Dept. Biomedical Sciences, College of Medicine, FSU
2020-2022: Seminar Committee, Dept. Biomedical Sciences, College of Medicine, FSU
2019-2020: Faculty Evaluation Committee, Dept. Biomedical Sciences, College of Medicine, FSU
2016 - 2018: Animal Care and Use Committee
2014 - present: Physician Assistant Curriculum Committee, College of Medicine
2013 - 2014: Graduate Committee, Dept. of Biomedical Sciences, College of Medicine
2013 - 2014: Faculty Search Committee, Dept. of Biomedical Sciences, College of Medicine
2013 - 2013: Promotion and Tenure Committee, Dept. of Biomedical Sciences, College of Medicine
Honors/Awards
- Outstanding Senior Faculty Researcher, Florida State University College of Medicine (2023).
- Outstanding Junior Faculty Researcher, Florida State University College of Medicine (2016).
- Cardiovascular Outreach Award, American Heart Association (2014).
- Outstanding Junior Faculty Researcher, Florida State University College of Medicine (2013).
- Stop Heart Disease Researcher of the Year, Florida Heart Research Institute (2013).
- Postdoctoral Fellow, American Heart Association (7/2008 - 6/2010).
- Travel Award Medical Faculty Association Margaret Whelan Fund, Miller School of Medicine University of Miami (2008).
- International Travel Grant, to attend the 50th Biophysical Society Meeting, Salt Lake City (2006).
- Grant IUPAB/UNESCO, to attend the 14th International Biophysical Congress, Buenos Aires (2002)
Memberships
Heart Rhythm Society
Biophysical Society
American Heart Association
Cardiac Muscle Society
American Society for Biochemistry & Molecular Biology (ASBMB)
Courses
Course Director, Physician Assistant Course, Systemic Physiology and Pathophysiology II – PAS5029
Course Director, Biomedical Sciences Graduate Course, Presentation Skills in Biomedical Sciences - GMS6955
Physician Assistant Course, Systemic Physiology and Pathophysiology I – PAS5028, Endocrine block
Physician Assistant Course, Integrated Clinical Sciences – PAS 5045, Lecture on Cardiomyopathies
Research Focus
Cardiac and skeletal muscle regulation and inherited diseases. Molecular basis of striated muscle contraction.
My research goals are; (i) to understand how allosteric mechanisms in troponin modulate the muscle response to calcium-dependent activation; (ii) to develop new genetic and molecular strategies for the reversal of cardiomyopathies, (iii) to define the role of nuclear troponin in heart development and disease; and (iv) to understand how post-translational modifications fine-tune muscle contraction and their roles in cardiac disease.
Publications
2024
Domínguez-García P, Pinto JR, Akrap A, Jeney S. ATP-induced reconfiguration of the micro-viscoelasticity of cardiac and skeletal myosin solutions. Appl. Phys. Lett. 2024 Oct 21; 125, 173702. doi: 10.1063/5.0224003
Landim-Vieira M, Pinto JR. Can evolution-based studies inform modern medicine? Science. 2024 Sep 27;385(6716):1420-1421. doi: 10.1126/science.ads2585.
Morales PN, Coons AN, Koopman AJ, Patel S, Chase PB, Parvatiyar MS, Pinto JR. Post-translational modifications of vertebrate striated muscle myosin heavy chains. Cytoskeleton (Hoboken). 2024 Apr 8:10.1002/cm.21857. doi: 10.1002/cm.21857.
Risi CM, Belknap B, Atherton J, Coscarella IL, White HD, Bryant Chase P, Pinto JR, Galkin VE. Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy. J Mol Biol. 2024 Feb 20;436(6):168498. doi: 10.1016/j.jmb.2024.168498.
Chen L, Liu J, Rastegarpouyani H, Janssen PML, Pinto JR, Taylor KA. Structure of mavacamten-free human cardiac thick filaments within the sarcomere by cryoelectron tomography. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2311883121. doi: 10.1073/pnas.2311883121. Epub 2024 Feb 22.
2023
Garcia MR, Schmeckpeper J, Landim-Vieira M, Coscarella IL, Fang X, Ma W, Spran PA, Yuan S, Qi L, Kahmini AR, Shoemaker MB, Atkinson JB, Kekenes-Huskey P, Irving TMC, Chase PB, Knollmann BC, Pinto JR. Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2. Int. J. Mol. Sci. 2023, 24(19), 14572; https://doi.org/10.3390/ijms241914572.
Coscarella IL, Landim-Vieira M, Rastegarpouyani H, Chase PB, Irianto J, Pinto JR. Nucleus Mechanosensing in Cardiomyocytes. Int J Mol Sci. 2023 Aug 28;24(17):13341. doi: 10.3390/ijms241713341.
Zhu L, Landim-Vieira M, Garcia MR, Pinto JR, Chalovich JM. Negative Charges Introduced Near the IT Helix of Cardiac Troponin T Stabilize the Active State of Actin Filaments. Biochemistry. 2023 Jun 28. doi: 10.1021/acs.biochem.3c00279.
Landim-Vieira M, Ma W, Song T, Rastegarpouyani H, Gong H, Coscarella IL, Bogaards SJP, Conijn SP, Ottenheijm CAC, Hwang HS, Papadaki M, Knollmann BC, Sadayappan S, Irving TC, Galkin VE, Chase PB, Pinto JR. Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function. Proc Natl Acad Sci U S A. 2023 Jun 6;120(23):e2221244120. doi: 10.1073/pnas.2221244120. Epub 2023 May 30.
Domínguez-García P, Pinto JR, Akrap A, Jeney S. Micro-mechanical response and power-law exponents from the longitudinal fluctuations of F-actin solutions. Soft Matter. 2023 May 24;19(20):3652-3660. doi: 10.1039/d2sm01445a.
Song T, Landim-Vieira M, Ozdemir M, Gott C, Kanisicak O, Pinto JR, Sadayappan S. Etiology of genetic muscle disorders induced by mutations in fast and slow skeletal MyBP-C paralogs. Exp Mol Med. 2023 Mar;55(3):502-509. doi: 10.1038/s12276-023-00953-x. Epub 2023 Mar 1.
Marston S, Pinto JR. Suppression of lusitropy as a disease mechanism in cardiomyopathies. Front Cardiovasc Med. 2023 Jan 9;9:1080965. doi: 10.3389/fcvm.2022.1080965. eCollection 2022.
2022
Sequeira V, Wang L, Wijnker PJM, Kim K, Pinto JR, Dos Remedios C, Redwood C, Knollmann BC, van der Velden J. Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy. J Mol Cell Cardiol Plus. 2022 Sep;1:100007. doi: 10.1016/j.jmccpl.2022.100007.
Risi CM, Belknap B, White HD, Dryden K, Pinto JR, Chase PB, Galkin VE. High-resolution cryo-EM structure of the junction region of the native cardiac thin filament in relaxed state. PNAS Nexus. 2022 Dec 16;2(1):pgac298. doi: 10.1093/pnasnexus/pgac298. eCollection 2023 Jan.
Landim-Vieira M, Kahmini AR, Engel M, Cannon EN, Amat-Alarcon N, Judge DP, Pinto JR, Chelko SP. Efficacy and Safety of Angiotensin Receptor Blockers in a Pre-Clinical Model of Arrhythmogenic Cardiomyopathy. Int J Mol Sci. 2022 Nov 11;23(22):13909. doi: 10.3390/ijms232213909.
Coscarella IL, Landim-Vieira M, Pinto JR, Chelko SP. Arrhythmogenic Cardiomyopathy: Exercise Pitfalls, Role of Connexin-43, and Moving beyond Antiarrhythmics. Int J Mol Sci. 2022 Aug 6;23(15):8753. doi: 10.3390/ijms23158753.
Parvatiyar MS, Pinto JR. On 'The content of troponin, tropomyosin, actin, and myosin in rabbit skeletal muscle myofibrils' by James D. Potter. Arch Biochem Biophys. 2022 Jun 2:109301. doi: 10.1016/j.abb.2022.109301.
Landim-Vieira M, Childers MC, Wacker AL, Garcia MR, He H, Singh R, Brundage EA, Johnston JR, Whitson BA, Chase PB, Janssen PML, Regnier M, Biesiadecki BJ, Pinto JR, Parvatiyar MS. Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts. Elife. 2022 May 3;11:e74919. doi: 10.7554/eLife.74919.
Ma, W., Gong, H., Jani, V., Lee, K.H., Landim-Vieira, M., Papadaki, M., Pinto, J.R., Aslam, M.I., Cammarato, A., Irving, T. Myofibril orientation as a metric for characterizing heart disease. Biophys J. 2022 Feb 15;121(4):565-574. doi: 10.1016/j.bpj.2022.01.009.
2021
Shi, Y., Bethea, J.P., Hetzel-Ebben, H.L., Landim-Vieira, M., Mayper, R.J., Williams, R.L., Kessler, L.E., Ruiz, A.M., Gargiulo, K., Rose, J.S.M., Platt, G., Pinto, J.R., Washburn, B.K., Chase, P.B. Mandibular muscle troponin of the Florida carpenter ant Camponotus floridanus: extending our insights into invertebrate Ca2+ regulation. J Muscle Res Cell Motil. 2021 Jul 13. doi: 10.1007/s10974-021-09606-w.
Caldwell, J.T., Jones, K.M.D., Park, H., Pinto, J.R., Ghosh, P., Reid-Foley, E.C., Ulrich, B., Delp, M.D., Behnke, B.J., Muller-Delp, J.M. Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin. Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H1-H14. doi: 10.1152/ajpheart.00885.2020.
Marques, M.A., Landim-Vieira, M., Moraes, A.H., Sun, B., Johnston, J.R., Jones, K.M.D., Cino, E.A., Parvatiyar, M.S., Valera, I.C., Silva, J.L., Galkin, V.E., Chase, P.B., Kekenes-Huskey, P., Oliveira, G.A.P., Pinto, J.R. Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy. Chem Sci. 2021 Apr 29;12(21):7308-7323. doi: 10.1039/d1sc01886h.
Song, T., McNamara, J.W., Ma, W., Landim-Vieira, M., Lee, K.W., Martin, L.A., Heiny, J.A., Lorenz, J.N., Craig, R., Pinto, J.R., Irving, T.C. and Sadayappan, S. Fast skeletal myosin binding protein-C regulates fast skeletal muscle contraction. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2003596118. doi: 10.1073/pnas.2003596118.
van de Locht, M., Donkervoort, S., de Winter, J.M., Conijn, S., Begthel, L., Kuster, B., Mohassel, P., Hu, Y., Medne, L., Quinn, C., Moore, S.A., Foley, A.R., Seo, G., Hwee, D.T., Malik, F.I., Irving, T., Ma, W., Granzier, H., Kamsteeg, E.J., Immadisetty, K., Kekenes-Huskey, P., Pinto, J.R., Voermans, N., Bonnemann, C.G., Ottenheijm, C.A. Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium. J Clin Invest. 2021 Mar 23:145700. doi: 10.1172/JCI145700.
Risi, C.M., Pepper, I., Belknap, B., White, H.D., Dryden, K., Pinto, J.R., Chase, P.B. and Galkin, V.E. The Structure of the Native Cardiac Thin Filament at Systolic Ca2+ Levels. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2024288118. doi: 10.1073/pnas.2024288118.
Schuldt, M., Johnston, J.R., He, H., Huurman, R., Pei, J., Harakalova, M., Poggesi, C., Michels, M., Kuster, D.W.D., Pinto, J.R., van der Velden, J. Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes. J Mol Cell Cardiol. 2021 Jan;150:77-90. doi: 10.1016/j.yjmcc.2020.10.006.
Reinoso, T.R., Landim-Vieira, M., Shi, Y., Johnston, J.R., Chase, P.B., Parvatiyar, M.S., Landstrom, A.P., Pinto, J.R., Tadros, H.J. A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C. J Muscle Res Cell Motil. 2021 June;42(2):323-342. doi: 10.1007/s10974-020-09592-5.
2020
Zot, H.G., Chase, P.B., Hasbun, J.E., Pinto, J.R. Mechanical contribution to muscle thin filament activation. J Biol Chem. 2020 Nov 20;295(47):15913-15922. doi: 10.1074/jbc.RA120.014438.
Johnson, D., Landim-Vieira, M., Solis-Ocampo, C., Zhu, L., Robinson, J., Pinto, J.R., Chalovich, J.M. Eliminating the First Inactive State and Stabilizing the Active State of the Cardiac Regulatory System Alters Behavior in Solution and in Ordered Systems. Biochemistry. 2020 Sep 22;59(37):3487-3497. doi: 10.1021/acs.biochem.0c00430
Serra, A.J., Pinto, J.R., Prokic, M.D., Arsa, G., Vasconsuelo, A. Oxidative Stress in Muscle Diseases: Current and Future Therapy 2019. Oxid Med Cell Longev. 2020 Apr 16;2020:6030417. doi: 10.1155/2020/6030417
Tadros, H.J., Life, C.S., Garcia, G., Pirozzi, E., Jones, E.G., Datta, S., Parvatiyar, M.S., Chase, P.B., Allen, H.D., Kim, J.J., Pinto, J.R., Landstrom, A.P. Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes. J Mol Cell Cardiol. 2020 May;142:118-125. doi: 10.1016/j.yjmcc.2020.04.005.
Dieseldorff Jones, K.M., Vied, C., Valera, I.C., Chase, P.B., Parvatiyar, M.S., Pinto, J.R. Sexual dimorphism in cardiac transcriptome associated with a troponin C murine model of hypertrophic cardiomyopathy. Physiol Rep. 2020 Mar;8(6):e14396. doi: 10.14814/phy2.14396.
Landim-Vieira, M., Johnston, J.R., Ji, W., Mis, E.K., Tijerino, J., Spencer-Manzon, M., Jeffries, L., Hall, E.K., Panisello-Manterola, D., Khokha, M.K., Deniz, E., Chase, P.B., Lakhani, S.A., Pinto, J.R. Familial Dilated Cardiomyopathy Associated With a Novel Combination of Compound Heterozygous TNNC1 Variants. Front Physiol. 2020 Jan 22;10:1612. doi: 10.3389/fphys.2019.01612.
2019
Johnston, J.R., Landim-Vieira, M., Marques, M.A., de Oliveira, G.A.P., Gonzalez-Martinez, D., Moraes, A.H., He, H., Iqbal, A., Wilnai, Y., Birk, E., Zucker, N., Silva, J.L., Chase, P.B., Pinto, J.R. The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation. J Biol Chem. 2019 Dec 27;294(52):20054-20069. doi: 10.1074/jbc.RA119.011177.
Johnson, D., Zhu, L., Landim-Vieira, M., Pinto, J.R., Chalovich, J.M. Basic residues within the cardiac troponin T C terminus are required for full inhibition of muscle contraction and limit activation by calcium. J Biol Chem. 2019 Dec 20;294(51):19535-19545. doi: 10.1074/jbc.RA119.010966.
Landim-Vieira, M., Schipper, J.M., Pinto, J.R., Chase, P.B. Cardiomyocyte nuclearity and ploidy: when is double trouble? J Muscle Res Cell Motil. 2019 Jul 17. doi: 10.1007/s10974-019-09545-7.
Parvatiyar, M.S., Brownstein, A.J., Kanashiro-Takeuchi, R.M., Collado, J.R., Dieseldorff Jones, K.M., Gopal, J., Hammond, K.G., Marshall, J.L., Ferrel, A., Beedle, A.M., Chamberlain, J.S., Pinto, J.R., Crosbie, R.H. Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathy. JCI Insight. Apr 30;5, 2019. doi: 10.1172/jci.insight.123855.
Marques, M.A., Parvatiyar, M.S., Yang, W., de Oliveira, G.A.P., Pinto, J.R. The missing links within troponin. Arch Biochem Biophys. 663:95-100, 2019. doi: 10.1016/j.abb.2018.12.026.
Dieseldorff Jones, K.M., Koh, Y., Weller, R.S., Turna, R.S., Ahmad, F., Huke, S., Knollmann, B.C., Pinto, J.R., Hwang, H.S. Pathogenic troponin T mutants with opposing effects on myofilament Ca2+ sensitivity attenuate cardiomyopathy phenotypes in mice. Arch Biochem Biophys. 661:125-131, 2019. doi: 10.1016/j.abb.2018.11.006.
2018
Gonzalez-Martinez, D., Johnston. J.R., Landim-Vieira, M., Ma, W., Antipova, O., Awan, O., Irving, T.C., Chase, P.B., Pinto, J.R. Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle. J Mol Cell Cardiol. 123:26-37, 2018. doi: 10.1016/j.yjmcc.2018.08.015.
Serra, A.J., Prokic, M.D., Vasconsuelo, A., Pinto, J.R. Oxidative Stress in Muscle Diseases: Current and Future Therapy. Oxid Med Cell Longev. 26; 2018:6439138, 2018. doi: 10.1155/2018/6439138. eCollection 2018.
Johnston, J.R., Chase, P.B., Pinto, J.R. Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction. Oncotarget, 9(1): 1461-1482, 2018. https://doi.org/10.18632/oncotarget.22879.
Wang, L., Kim, K., Parikh, S., Cadar, A.G., Bersell, K.R., He, H., Pinto, J.R., Kryshtal, D.O., Knollmann, B,C. Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes. J Mol Cell Cardiol. 114:320-327, 2018. doi: 10.1016/j.yjmcc.2017.12.002.
2017
Wang, L., Kryshtal, D.O., Kim, K., Parikh, S., Cadar, A.G., Bersell, K.R., He, H., Pinto, J.R., Knollmann, B.C. Myofilament Calcium-Buffering Dependent Action Potential Triangulation in Human-Induced Pluripotent Stem Cell Model of Hypertrophic Cardiomyopathy. J Am Coll Cardiol. 70(20):2600-2602, 2017. doi: 10.1016/j.jacc.2017.09.033.
Baxley, T., Johnson, D., Pinto, J.R., Chalovich, J.M. Troponin C mutations partially stabilize the active state of regulated actin and fully stabilize the active state when paired with D14 TnT. Biochemistry 56(23): 2928-2937, 2017. doi: 10.1021/acs.biochem.6b01092.
Bollen, I.A.E., Schuldt, M., Harakalova, M., Vink, A., Asselbergs, F.W., Pinto, J.R., Krüger, M., Kuster, D.W.D., Van der Velden, J. Genotype-specific pathogenic effects in human dilated cardiomyopathy. J. Physiol. 595(14): 4677-4693, 2017. doi: 10.1113/JP274145.
Dossat, A.M., Sanchez-Gonzalez, M.A., Koutnik, A.P., Leitner, S., Ruiz, E.L., Griffin, B., Rosenberg, J.T., Grant, S.C., Fincham, F.D., Pinto, J.R., Kabbaj, M. Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy. FASEB J. 31(6): 2492-2506, 2017. doi: 10.1096/fj.201600955RR.
Kawai, M., Johnston, J.R., Karam, T., Wang, L., Singh, R.K., Pinto, J.R. Myosin Rod Hypophosphorylation and CB Kinetics in Papillary Muscles from a TnC-A8V KI Mouse Model. Biophys. J. (London) 112(8): 1726-1736, 2017. doi: http://dx.doi.org/10.1016/j.bpj.2017.02.045
Veltri, T., Landim-Vieira, M., Parvatiyar, M.S., Gonzalez-Martinez, D., Dieseldorff Jones, K.M., Michell, C.A., Dweck, D., Landstrom, A.P., Chase, P.B., Pinto, J.R. Hypertrophic cardiomyopathy cardiac Troponin C mutations defferentially affect slow skeletal and cardiac muscle regulation. Front. Physiol. April(8): 221, 2017. doi: 10.3389/fphys.2017.00221.
Veltri, T., de Oliveira, G.A., Bienkiewicz, E.A., Palhano, F.L., Marques, M.A., Moraes, A.H., Silva, J.L., Sorenson, M.M., Pinto, J.R. Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C. Sci Rep. Apr 6;7(1):691, 2017. doi: 10.1038/s41598-017-00777-6.
Pinto, J.R., Muller-Delp, J., Chase, P.B. Will you still need me (Ca2+ , TnT, and DHPR), will you still cleave me (calpain), when I'm 64? Aging Cell. Apr;16(2):202-204, 2017. doi: 10.1111/acel.12560
Marques, M.A., Pinto, J.R., Moraes, A.H., Iqbal, A., de Magalhães, M.T., Monteiro, J., Pedrote, M.M., Sorenson, M.M., Silva, J.L., de Oliveira, G.A. Allosteric transmission along a loosely structured backbone allows a cardiac Troponin C mutant to function with only one Ca2+ ion. J Biol Chem. Feb 10;292(6):2379-2394, 2017. doi: 10.1074/jbc.M116.765362.
2016
Badr, M.A., Pinto, J.R., Davidson, M.W., Chase, P.B. Fluorescent Protein-Based Ca2+ Sensor Reveals Global, Divalent Cation-Dependent Conformational Changes in Cardiac Troponin C. PLoS One. Oct 13;11(10):e0164222, 2016. doi: 10.1371/journal.pone.0164222
Sheng, J.J., Feng, HZ., Pinto, J.R., Wei, H., Jin, J.P. Increases of desmin and a-actinin in mouse cardiac myofibrils as a response to diastolic dysfunction. J Mol Cell Cardiol. Oct;99:218-229, 2016. doi: 10.1016/j.yjmcc.2015.10.035
Na, I., Kong, M.J., Straight, S., Pinto, J.R., Uversky, V.N. Troponins, intrinsic disorder, and cardiomyopathy. Biol Chem. Aug 1;397(8):731-51, 2016. doi: 10.1515/hsz-2015-0303
Zot, H.G., Hasbun, J.E., Michell, C.A., Landim-Vieira, M., Pinto, J.R. Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C. Arch Biochem Biophys. Jul 1;601:97-104, 2016. doi: 10.1016/j.abb.2016.03.011
2015
Figueiredo-Freitas, C., Dulce, R., Foster, M.W., Liang, J., Yamashita, A.M., Lima-Rosa, F.L., Thompson, W.J., Moseley, A.M., Hare, J.M., Nogueira, L., Sorenson, M.M., Pinto, J.R. S-nitrosylation of sarcomeric proteins depresses myofilament Ca2+ sensitivity in intact cardiomyocytes. Antioxid Redox Signal. Nov 1;23(13):1017-34, 2015. doi: 10.1089/ars.2015.6275
Martins, A.S., Parvatiyar, M.S., Feng, HZ., Bos, J.M., Gonzalez-Martinez, D., Vukmirovic, M., Turna, R.S., Sanchez-Gonzalez, M.A., Badger, C.D., Zorio, D.A., Singh, R.K., Wang, Y., Jin, J.P., Ackerman, M.J., Pinto, J.R. In vivo Analysis of Troponin C Knock-in (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene. Circ Cardiovasc Genet. Oct;8(5):653-64, 2015
Chang, A.N., Battiprolu, P.K., Cowley, P.M., Chen, G., Gerard, R.D., Pinto, J.R., Hill, J.A., Baker, A.J., Kamm, K.E., Stull, J.T. Constitutive Phosphorylation of Cardiac Myosin Regulatory Light Chain in vivo. J. Biol. Chem. 290(17):10703-16, 2015
Parvatiyar, M.S. and Pinto, J.R. Pathogenesis Associated with a Restrictive Cardiomyopathy Mutant in Cardiac Troponin T is Due to Reduced Protein Stability and Greatly Increased Myofilament Ca2+ Sensitivity. Biochim. Biophys. Acta. Feb;1850(2):365-72, 2015
2014
Chang, A.N., Greenfield, N.J., Singh, A., Potter, J.D., Pinto, J.R. Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin. Front. Physiol. Dec 2;5:460, 2014
Dweck, D., Sanchez-Gonzalez, M.A., Chang, A., Dulce, R., Badger, CD., Koutnik, A.P., Ruiz, E.L., Griffin, B., Liang, J., Kabbaj, M., Fincham, F., Hare, J., Overton, M.J., Pinto, J.R. Long term ablation of PKA-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a Knock-in mouse model of Hypertrophic Cardiomyopathy. J. Biol. Chem. 289:23097-23111, 2014
2013
Bai, F., Caster, H.M., Pinto, J.R., and Kawai, M. Functional properties of cardiomyopathy causing cTnT mutants I79N, DE96 and DK210: molecular pathogenesis study. Biophys. J. (London) 104(9): 1979-1988, 2013
Venkataraman, R., Baldo, M.P., Hwang, H., Veltri, T., Pinto, J.R., Baudenbacher, F.J., Knollmann, B.C. Myofilament calcium de-sensitization and contractile uncoupling with blebbistatin prevents ventricular tachycardia in mouse hearts with chronic myocardial infarction. J. Mol. Cell. Cardiol. 60C: 8-15, 2013
2012
Pinto, J.R., Gomes, A.V., Jones, M.A., Liang, J., Nguyen, S., Miller, T., Parvatiyar, M.S., and Potter, J.D. The Functional Properties of Human Slow Skeletal TnT Isoforms in the Cardiac Muscle Regulation. J. Biol. Chem. 287(44): 37362-70, 2012
Tao, G., Levay, A.K., Peacock, J.D., Huk, D.J., Both, S.N., Purcell, N.H., Pinto, J.R., Galantowicz, M.L., Koch, M., Lucchesi, P.A., Birk, D.E. and Lincoln J. Collagen XIV is important for growth and structural integrity of the myocardium. J. Mol. Cell. Cardiol. Nov;53(5):626-38, 2012
Parvatiyar, M., Landstrom, A., Figueiro-Freitas, C., Potter, J.D., Ackerman, M.J., Pinto, J.R. A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation. J. Biol. Chem. 287(38):31845-31855, 2012
Ueta, C.B., Oskouei, B.N., Olivares, E.L., Pinto, J.R., Correa, M.M., Simovic, G., Simonides, W.S., Hare, J.M., Bianco, A.C. Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice. Mol Endocrinol. May;26(5): 809-18, 2012
Wang, Y., Pinto, J.R., Sancho Solis, R., Dweck, D., Liang, J., Diaz-Perez, Z., Ge, Y., Walker, J.W., Potter, J.D. The Generation and Functional Characterization of Knock-In Mice Harboring the Cardiac-troponin I R21C Mutation Associated with Hypertrophic Cardiomyopathy. J. Biol. Chem. 287(3): 2156-2167, 2012
2011
Pinto, J.R., Siegfried, J.D., Parvatiyar, M.S., Li, D., Norton, N., Jones, M.A., Liang, J., Potter, J.D., Hershberger, R.E. Functional Characterization of TNNC1 Rare Variants Identified in Dilated Cardiomyopathy. J. Biol. Chem. 286(39): 34404-34412, 2011
Midde, K., Dumka, V., Pinto, J.R., Muthu, P., Marandos, P., Gryczynski, I., Gryczynski, Z., Potter, J.D., Borejdo, J. Myosin cross-bridges do not form precise rigor bonds in hypertrophic heart muscle carrying troponin T mutations. J Mol Cell Cardiol. Sep;51(3): 409-418, 2011
Pinto, J.R., Yang, S.W., Hitz, M.P., Parvatiyar, M.S., Jones, M.A., Liang, J., Victor, K., Talajic, M., Tremblay, N., Jaeggi, M., Andelfinger, G. and Potter, J.D. Fetal Cardiac Troponin Isoforms Rescue the Increased Ca2+ Sensitivity Produced by a Novel Double Deletion in Cardiac Troponin T Linked to Restrictive Cardiomyopathy. A Clinical, Genetic and Functional Approach. J. Biol. Chem. 286(23): 20901-20912, 2011
Pinto, J.R., Sousa, V.P. and Sorenson, M.M. Redox State of Troponin C Cysteine in the D/E Helix Alters the C-domain Affinity for the Thin Filament of Vertebrate Striated Muscle. BBA - Gen Subj. 1810(4): 391-397, 2011
Pinto, J.R., Reynaldo, D.P., Parvatiyar, M.S., Dweck, D., Liang, J., Jones, M.A., Sorenson, M.M. and Potter, J.D. Strong Crossbridges Potentiate the Ca2+ Affinity Changes Produced by HCM-Cardiac Troponin C Mutants in Myofilaments. A Fast Kinetic Approach. J. Biol. Chem. 286(2): 1005-1013, 2011
2010
Morales, A., Pinto, J.R., Siegfried, J.D., Li, D., Norton, N., Hofmeyer, M., Vallin, M., Morales, A.R., Potter, J.D. and Hershberger, R.E. Late onset sporadic dilated cardiomyopathy caused by a cardiac troponin T mutation. Clin. Trans. Sci. 3:219-226, 2010
Parvatiyar, M.S., Pinto, J.R., Liang, J.S. and Potter, J.D. Predicting Cardiomyopathic Phenotypes by Altering the Ca2+ Affinity of Cardiac Troponin C. J. Biol. Chem. 285(36): 27785-97, 2010
Li, Y., Charles, P.Y.J., Nan, C., Pinto, J.R., Wang, Y., Liang, J., Wu, G., Tian, J., Feng, H.Z., Potter, J.D., Jin, J.P. and Huang, X. Correcting diastolic dysfunction by desensitizing troponin in transgenic RCM mice. J. Mol. Cell. Card. 49: 402-411, 2010
Dweck, D., Reynaldo, D.P., Pinto, J.R. and Potter, J.D. A Dilated Cardiomyopathy Troponin C Mutation Lowers Contractile Force by Reducing Strong Myosin-Actin Binding. J. Biol. Chem. 285(23): 17371-17379, 2010
Parvatiyar, M.S., Pinto, J.R., Dweck, D. and Potter, J.D. Cardiac Troponin Mutations and Restrictive Cardiomyopathy. J. Biomed. Biotechnol. ID 350706, 2010
Willott, R.W., Gomes, A.V., Parvatiyar, M.S., Chang, A., Pinto, J.R. and Potter, J.D. Mutation in Troponin that Cause Hypertrophic, Dilated and Restrictive Cardiomyopathy: What Can We Learn About Thin Filament Function? J. Mol. Cell Card. 48: 882-892, 2010
2009
Wen, Y., Xu, Y., Wang, Y., Pinto, J.R., Potter, J.D. and Kerrick, W.G.L. Functional Effects of a Restrictive Cardiomyopathy linked Cardiac Troponin I mutation (R145W) in Transgenic Mice. J. Mol. Biol., 392(5): 1158-1167, 2009
Pinto, J.R., Parvatiyar, M.S., Jones, M.A., Liang, J., Ackerman, M.J. and Potter, J.D. A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy. J. Biol. Chem, 284(28): 19090-19100, 2009
Hershberger, R.E., Pinto, J.R., Parks, S.B., Kushner, J.D., Li, D., Ludwigsen, S., Cowan, J., Morales, A., Parvatiyar, M.S. and Potter, J.D. Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy. Circulation: Cardiovasc. Genet., 2: 306-313, 2009
2008
Baudenbacher, F., Schober, T., Pinto, J.R., Sidorov, V., Hilliard, F., Solaro, R.J., Potter, J.D. and Knollmann, B.C. Myofilament Calcium Sensitization Causes Susceptibility to Cardiac Arrhythmia in Mice. J. Clin. Invest., 188(12): 3893-3903, 2008
Wen, Y., Pinto, J.R., Xu, Y., Wang, Y., Wang, Y., Gomes, A.V., Potter, J.D. and Kerrick, W.G.L. Functional Consequences of a Cardiac Troponin I (R145G) Mutation Associated with Hypertrophic Cardiomyopathy in Transgenic Mice. J. Biol. Chem., 283(29): 20484-20494, 2008
Landstrom, A.P.*, Parvatiyar, M.S.*, Pinto, J.R.*, Marquardt, M.L., Bos, J.M., Tester, D.J., Ommen, S.R., Potter, J.D. and Ackerman, M.J. Molecular and Functional Characterization of Novel Hypertrophic Cardiomyopathy Susceptibility Mutations in TNNC1- Encoded Troponin C. J. Mol. Cell Card., 45: 281-288, 2008 (*Co-first author)
Pinto, J.R., Veltri, T. and Sorenson, M.M. Modulation of Troponin C Affinity for the Thin Filament by Different Types of Crossbridges in Skinned Skeletal Muscle. Pflugers Archive, 456: 1177-1187, 2008
Pinto, J.R., Parvatiyar, M.S., Jones, M.A., Liang, J. and Potter, J.D. A Troponin T Mutation that Causes Infantile Restrictive Cardiomyopathy Increases Ca2+ Sensitivity of Force Development and Impairs the Inhibitory Properties of Troponin. J. Biol. Chem. 283: 2156-2166, 2008
2006
Sousa, V.P., Pinto, J.R. and Sorenson, M.M. Ionic Interventions that Alter the Association of Troponin C C-domain with the Thin Filaments of Vertebrate Striated Muscle. Biochim. Biophys. Acta (Gen. Subj.) 1760: 272-282, 2006
Braga, C.A.C.A., Pinto, J.R., Valente, A.P., Silva, J.L., Sorenson, M.M., Foguel, D. and Suarez, M.C. Ca2+ and Mg2+ Binding to the Weak Sites of TnC C-domain Induces Exposure of a Large Hydrophobic Surface that Leads to Loss of TnC from the Thin Filament. Intl. J. Biochem. Cell Biol. 38: 110-122, 2006
2004
Costa, L.T., Pinto, J.R., Moraes, M.B., Bastos, G.G., Sorenson, M.M., Bisch, P.M. and Weissmüller, G. Chemical Treatment of Mica for Atomic Force Microscopy Can Affect Biological Sample Conformation. Biophys. Chem. 109: 63-71, 2004
Dr. Jose R. Pinto earned his Ph.D in 2006 from the Federal University of Rio de Janeiro. His research of study is Muscle Biochemistry and Biophysics. He researched as a postdoctoral scholar from 2006 to 2010 at the University of Miami, Miller School of Medicine under the mentoring of Dr. James D. Potter. His postdoctoral research focus was on the Molecular Mechanisms of Inherited Cardiomyopathies. In 2010, Dr. Pinto became a research assistant professor until he joined the FSU College of Medicine Biomedical Sciences Department in 2011. Dr. Pinto was promoted to Associate Professor with Tenure in 2017 and then to Full Professor in 2023.
CURRENTLY ACCEPTING NEW GRADUATE STUDENTS
Ph.D. in Medical Biochemistry (2006), Federal University of Rio de Janeiro - Brazil
Postdoctoral training (2006 - 2010), University of Miami, Miller School of Medicine - USA
Editorial Board:
Associate Editor: Scientific Reports, IJMS, BBR & Frontiers in Physiology
Editorial Board: BBA Gen Subjects & ABB
Peer Review responsibilities:
2022 - NIH MPPA Standing Member
2021 - NIH MPPA
2021 - VA CARA
2020 - NIH F10A-R (20) L ZRG1
2020 - NIH MIM
2020 – AHA TPA Cardiac Basic Sciences
2019 – NIH F10-A-R (20) L ZRG1
2019 – NIH CCHF (ad hoc)
2019 – NIH consultant – Member of a PPG committee
2017 – Wellcome Trust, UK
2017 – Prinses Beatrix Spierfonds, The Netherlands
2016-2017 – NIH ZRG1 MOSS D(82)
2016 – AHA, Strategically Focused Research Network – Heart Failure
2014 - present – FSU - CRC-COFRS grant review
2014 - Netherlands Organisation for Scientific Research (NWO)
Jan/2013 – NIH consultant – Member of a PPG committee.
2012 - present - American Heart Association. Member of the Cardiac Biology Basic Science 4 committee.
At Florida State University
2023-present Promotion and Tenure Committee, Dept. Biomedical Sciences, College of Medicine, FSU
2023-present Faculty Council Executive Committee, College of Medicine, FSU
2020-present Graduate Program Committee, Dept. Biomedical Sciences, College of Medicine, FSU
2020-2022: Seminar Committee, Dept. Biomedical Sciences, College of Medicine, FSU
2019-2020: Faculty Evaluation Committee, Dept. Biomedical Sciences, College of Medicine, FSU
2016 - 2018: Animal Care and Use Committee
2014 - present: Physician Assistant Curriculum Committee, College of Medicine
2013 - 2014: Graduate Committee, Dept. of Biomedical Sciences, College of Medicine
2013 - 2014: Faculty Search Committee, Dept. of Biomedical Sciences, College of Medicine
2013 - 2013: Promotion and Tenure Committee, Dept. of Biomedical Sciences, College of Medicine
- Outstanding Senior Faculty Researcher, Florida State University College of Medicine (2023).
- Outstanding Junior Faculty Researcher, Florida State University College of Medicine (2016).
- Cardiovascular Outreach Award, American Heart Association (2014).
- Outstanding Junior Faculty Researcher, Florida State University College of Medicine (2013).
- Stop Heart Disease Researcher of the Year, Florida Heart Research Institute (2013).
- Postdoctoral Fellow, American Heart Association (7/2008 - 6/2010).
- Travel Award Medical Faculty Association Margaret Whelan Fund, Miller School of Medicine University of Miami (2008).
- International Travel Grant, to attend the 50th Biophysical Society Meeting, Salt Lake City (2006).
- Grant IUPAB/UNESCO, to attend the 14th International Biophysical Congress, Buenos Aires (2002)
Heart Rhythm Society
Biophysical Society
American Heart Association
Cardiac Muscle Society
American Society for Biochemistry & Molecular Biology (ASBMB)
Course Director, Physician Assistant Course, Systemic Physiology and Pathophysiology II – PAS5029
Course Director, Biomedical Sciences Graduate Course, Presentation Skills in Biomedical Sciences - GMS6955
Physician Assistant Course, Systemic Physiology and Pathophysiology I – PAS5028, Endocrine block
Physician Assistant Course, Integrated Clinical Sciences – PAS 5045, Lecture on Cardiomyopathies
Cardiac and skeletal muscle regulation and inherited diseases. Molecular basis of striated muscle contraction.
My research goals are; (i) to understand how allosteric mechanisms in troponin modulate the muscle response to calcium-dependent activation; (ii) to develop new genetic and molecular strategies for the reversal of cardiomyopathies, (iii) to define the role of nuclear troponin in heart development and disease; and (iv) to understand how post-translational modifications fine-tune muscle contraction and their roles in cardiac disease.
2024
Domínguez-García P, Pinto JR, Akrap A, Jeney S. ATP-induced reconfiguration of the micro-viscoelasticity of cardiac and skeletal myosin solutions. Appl. Phys. Lett. 2024 Oct 21; 125, 173702. doi: 10.1063/5.0224003
Landim-Vieira M, Pinto JR. Can evolution-based studies inform modern medicine? Science. 2024 Sep 27;385(6716):1420-1421. doi: 10.1126/science.ads2585.
Morales PN, Coons AN, Koopman AJ, Patel S, Chase PB, Parvatiyar MS, Pinto JR. Post-translational modifications of vertebrate striated muscle myosin heavy chains. Cytoskeleton (Hoboken). 2024 Apr 8:10.1002/cm.21857. doi: 10.1002/cm.21857.
Risi CM, Belknap B, Atherton J, Coscarella IL, White HD, Bryant Chase P, Pinto JR, Galkin VE. Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy. J Mol Biol. 2024 Feb 20;436(6):168498. doi: 10.1016/j.jmb.2024.168498.
Chen L, Liu J, Rastegarpouyani H, Janssen PML, Pinto JR, Taylor KA. Structure of mavacamten-free human cardiac thick filaments within the sarcomere by cryoelectron tomography. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2311883121. doi: 10.1073/pnas.2311883121. Epub 2024 Feb 22.
2023
Garcia MR, Schmeckpeper J, Landim-Vieira M, Coscarella IL, Fang X, Ma W, Spran PA, Yuan S, Qi L, Kahmini AR, Shoemaker MB, Atkinson JB, Kekenes-Huskey P, Irving TMC, Chase PB, Knollmann BC, Pinto JR. Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2. Int. J. Mol. Sci. 2023, 24(19), 14572; https://doi.org/10.3390/ijms241914572.
Coscarella IL, Landim-Vieira M, Rastegarpouyani H, Chase PB, Irianto J, Pinto JR. Nucleus Mechanosensing in Cardiomyocytes. Int J Mol Sci. 2023 Aug 28;24(17):13341. doi: 10.3390/ijms241713341.
Zhu L, Landim-Vieira M, Garcia MR, Pinto JR, Chalovich JM. Negative Charges Introduced Near the IT Helix of Cardiac Troponin T Stabilize the Active State of Actin Filaments. Biochemistry. 2023 Jun 28. doi: 10.1021/acs.biochem.3c00279.
Landim-Vieira M, Ma W, Song T, Rastegarpouyani H, Gong H, Coscarella IL, Bogaards SJP, Conijn SP, Ottenheijm CAC, Hwang HS, Papadaki M, Knollmann BC, Sadayappan S, Irving TC, Galkin VE, Chase PB, Pinto JR. Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function. Proc Natl Acad Sci U S A. 2023 Jun 6;120(23):e2221244120. doi: 10.1073/pnas.2221244120. Epub 2023 May 30.
Domínguez-García P, Pinto JR, Akrap A, Jeney S. Micro-mechanical response and power-law exponents from the longitudinal fluctuations of F-actin solutions. Soft Matter. 2023 May 24;19(20):3652-3660. doi: 10.1039/d2sm01445a.
Song T, Landim-Vieira M, Ozdemir M, Gott C, Kanisicak O, Pinto JR, Sadayappan S. Etiology of genetic muscle disorders induced by mutations in fast and slow skeletal MyBP-C paralogs. Exp Mol Med. 2023 Mar;55(3):502-509. doi: 10.1038/s12276-023-00953-x. Epub 2023 Mar 1.
Marston S, Pinto JR. Suppression of lusitropy as a disease mechanism in cardiomyopathies. Front Cardiovasc Med. 2023 Jan 9;9:1080965. doi: 10.3389/fcvm.2022.1080965. eCollection 2022.
2022
Sequeira V, Wang L, Wijnker PJM, Kim K, Pinto JR, Dos Remedios C, Redwood C, Knollmann BC, van der Velden J. Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy. J Mol Cell Cardiol Plus. 2022 Sep;1:100007. doi: 10.1016/j.jmccpl.2022.100007.
Risi CM, Belknap B, White HD, Dryden K, Pinto JR, Chase PB, Galkin VE. High-resolution cryo-EM structure of the junction region of the native cardiac thin filament in relaxed state. PNAS Nexus. 2022 Dec 16;2(1):pgac298. doi: 10.1093/pnasnexus/pgac298. eCollection 2023 Jan.
Landim-Vieira M, Kahmini AR, Engel M, Cannon EN, Amat-Alarcon N, Judge DP, Pinto JR, Chelko SP. Efficacy and Safety of Angiotensin Receptor Blockers in a Pre-Clinical Model of Arrhythmogenic Cardiomyopathy. Int J Mol Sci. 2022 Nov 11;23(22):13909. doi: 10.3390/ijms232213909.
Coscarella IL, Landim-Vieira M, Pinto JR, Chelko SP. Arrhythmogenic Cardiomyopathy: Exercise Pitfalls, Role of Connexin-43, and Moving beyond Antiarrhythmics. Int J Mol Sci. 2022 Aug 6;23(15):8753. doi: 10.3390/ijms23158753.
Parvatiyar MS, Pinto JR. On 'The content of troponin, tropomyosin, actin, and myosin in rabbit skeletal muscle myofibrils' by James D. Potter. Arch Biochem Biophys. 2022 Jun 2:109301. doi: 10.1016/j.abb.2022.109301.
Landim-Vieira M, Childers MC, Wacker AL, Garcia MR, He H, Singh R, Brundage EA, Johnston JR, Whitson BA, Chase PB, Janssen PML, Regnier M, Biesiadecki BJ, Pinto JR, Parvatiyar MS. Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts. Elife. 2022 May 3;11:e74919. doi: 10.7554/eLife.74919.
Ma, W., Gong, H., Jani, V., Lee, K.H., Landim-Vieira, M., Papadaki, M., Pinto, J.R., Aslam, M.I., Cammarato, A., Irving, T. Myofibril orientation as a metric for characterizing heart disease. Biophys J. 2022 Feb 15;121(4):565-574. doi: 10.1016/j.bpj.2022.01.009.
2021
Shi, Y., Bethea, J.P., Hetzel-Ebben, H.L., Landim-Vieira, M., Mayper, R.J., Williams, R.L., Kessler, L.E., Ruiz, A.M., Gargiulo, K., Rose, J.S.M., Platt, G., Pinto, J.R., Washburn, B.K., Chase, P.B. Mandibular muscle troponin of the Florida carpenter ant Camponotus floridanus: extending our insights into invertebrate Ca2+ regulation. J Muscle Res Cell Motil. 2021 Jul 13. doi: 10.1007/s10974-021-09606-w.
Caldwell, J.T., Jones, K.M.D., Park, H., Pinto, J.R., Ghosh, P., Reid-Foley, E.C., Ulrich, B., Delp, M.D., Behnke, B.J., Muller-Delp, J.M. Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin. Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H1-H14. doi: 10.1152/ajpheart.00885.2020.
Marques, M.A., Landim-Vieira, M., Moraes, A.H., Sun, B., Johnston, J.R., Jones, K.M.D., Cino, E.A., Parvatiyar, M.S., Valera, I.C., Silva, J.L., Galkin, V.E., Chase, P.B., Kekenes-Huskey, P., Oliveira, G.A.P., Pinto, J.R. Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy. Chem Sci. 2021 Apr 29;12(21):7308-7323. doi: 10.1039/d1sc01886h.
Song, T., McNamara, J.W., Ma, W., Landim-Vieira, M., Lee, K.W., Martin, L.A., Heiny, J.A., Lorenz, J.N., Craig, R., Pinto, J.R., Irving, T.C. and Sadayappan, S. Fast skeletal myosin binding protein-C regulates fast skeletal muscle contraction. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2003596118. doi: 10.1073/pnas.2003596118.
van de Locht, M., Donkervoort, S., de Winter, J.M., Conijn, S., Begthel, L., Kuster, B., Mohassel, P., Hu, Y., Medne, L., Quinn, C., Moore, S.A., Foley, A.R., Seo, G., Hwee, D.T., Malik, F.I., Irving, T., Ma, W., Granzier, H., Kamsteeg, E.J., Immadisetty, K., Kekenes-Huskey, P., Pinto, J.R., Voermans, N., Bonnemann, C.G., Ottenheijm, C.A. Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium. J Clin Invest. 2021 Mar 23:145700. doi: 10.1172/JCI145700.
Risi, C.M., Pepper, I., Belknap, B., White, H.D., Dryden, K., Pinto, J.R., Chase, P.B. and Galkin, V.E. The Structure of the Native Cardiac Thin Filament at Systolic Ca2+ Levels. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2024288118. doi: 10.1073/pnas.2024288118.
Schuldt, M., Johnston, J.R., He, H., Huurman, R., Pei, J., Harakalova, M., Poggesi, C., Michels, M., Kuster, D.W.D., Pinto, J.R., van der Velden, J. Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes. J Mol Cell Cardiol. 2021 Jan;150:77-90. doi: 10.1016/j.yjmcc.2020.10.006.
Reinoso, T.R., Landim-Vieira, M., Shi, Y., Johnston, J.R., Chase, P.B., Parvatiyar, M.S., Landstrom, A.P., Pinto, J.R., Tadros, H.J. A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C. J Muscle Res Cell Motil. 2021 June;42(2):323-342. doi: 10.1007/s10974-020-09592-5.
2020
Zot, H.G., Chase, P.B., Hasbun, J.E., Pinto, J.R. Mechanical contribution to muscle thin filament activation. J Biol Chem. 2020 Nov 20;295(47):15913-15922. doi: 10.1074/jbc.RA120.014438.
Johnson, D., Landim-Vieira, M., Solis-Ocampo, C., Zhu, L., Robinson, J., Pinto, J.R., Chalovich, J.M. Eliminating the First Inactive State and Stabilizing the Active State of the Cardiac Regulatory System Alters Behavior in Solution and in Ordered Systems. Biochemistry. 2020 Sep 22;59(37):3487-3497. doi: 10.1021/acs.biochem.0c00430
Serra, A.J., Pinto, J.R., Prokic, M.D., Arsa, G., Vasconsuelo, A. Oxidative Stress in Muscle Diseases: Current and Future Therapy 2019. Oxid Med Cell Longev. 2020 Apr 16;2020:6030417. doi: 10.1155/2020/6030417
Tadros, H.J., Life, C.S., Garcia, G., Pirozzi, E., Jones, E.G., Datta, S., Parvatiyar, M.S., Chase, P.B., Allen, H.D., Kim, J.J., Pinto, J.R., Landstrom, A.P. Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes. J Mol Cell Cardiol. 2020 May;142:118-125. doi: 10.1016/j.yjmcc.2020.04.005.
Dieseldorff Jones, K.M., Vied, C., Valera, I.C., Chase, P.B., Parvatiyar, M.S., Pinto, J.R. Sexual dimorphism in cardiac transcriptome associated with a troponin C murine model of hypertrophic cardiomyopathy. Physiol Rep. 2020 Mar;8(6):e14396. doi: 10.14814/phy2.14396.
Landim-Vieira, M., Johnston, J.R., Ji, W., Mis, E.K., Tijerino, J., Spencer-Manzon, M., Jeffries, L., Hall, E.K., Panisello-Manterola, D., Khokha, M.K., Deniz, E., Chase, P.B., Lakhani, S.A., Pinto, J.R. Familial Dilated Cardiomyopathy Associated With a Novel Combination of Compound Heterozygous TNNC1 Variants. Front Physiol. 2020 Jan 22;10:1612. doi: 10.3389/fphys.2019.01612.
2019
Johnston, J.R., Landim-Vieira, M., Marques, M.A., de Oliveira, G.A.P., Gonzalez-Martinez, D., Moraes, A.H., He, H., Iqbal, A., Wilnai, Y., Birk, E., Zucker, N., Silva, J.L., Chase, P.B., Pinto, J.R. The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation. J Biol Chem. 2019 Dec 27;294(52):20054-20069. doi: 10.1074/jbc.RA119.011177.
Johnson, D., Zhu, L., Landim-Vieira, M., Pinto, J.R., Chalovich, J.M. Basic residues within the cardiac troponin T C terminus are required for full inhibition of muscle contraction and limit activation by calcium. J Biol Chem. 2019 Dec 20;294(51):19535-19545. doi: 10.1074/jbc.RA119.010966.
Landim-Vieira, M., Schipper, J.M., Pinto, J.R., Chase, P.B. Cardiomyocyte nuclearity and ploidy: when is double trouble? J Muscle Res Cell Motil. 2019 Jul 17. doi: 10.1007/s10974-019-09545-7.
Parvatiyar, M.S., Brownstein, A.J., Kanashiro-Takeuchi, R.M., Collado, J.R., Dieseldorff Jones, K.M., Gopal, J., Hammond, K.G., Marshall, J.L., Ferrel, A., Beedle, A.M., Chamberlain, J.S., Pinto, J.R., Crosbie, R.H. Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathy. JCI Insight. Apr 30;5, 2019. doi: 10.1172/jci.insight.123855.
Marques, M.A., Parvatiyar, M.S., Yang, W., de Oliveira, G.A.P., Pinto, J.R. The missing links within troponin. Arch Biochem Biophys. 663:95-100, 2019. doi: 10.1016/j.abb.2018.12.026.
Dieseldorff Jones, K.M., Koh, Y., Weller, R.S., Turna, R.S., Ahmad, F., Huke, S., Knollmann, B.C., Pinto, J.R., Hwang, H.S. Pathogenic troponin T mutants with opposing effects on myofilament Ca2+ sensitivity attenuate cardiomyopathy phenotypes in mice. Arch Biochem Biophys. 661:125-131, 2019. doi: 10.1016/j.abb.2018.11.006.
2018
Gonzalez-Martinez, D., Johnston. J.R., Landim-Vieira, M., Ma, W., Antipova, O., Awan, O., Irving, T.C., Chase, P.B., Pinto, J.R. Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle. J Mol Cell Cardiol. 123:26-37, 2018. doi: 10.1016/j.yjmcc.2018.08.015.
Serra, A.J., Prokic, M.D., Vasconsuelo, A., Pinto, J.R. Oxidative Stress in Muscle Diseases: Current and Future Therapy. Oxid Med Cell Longev. 26; 2018:6439138, 2018. doi: 10.1155/2018/6439138. eCollection 2018.
Johnston, J.R., Chase, P.B., Pinto, J.R. Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction. Oncotarget, 9(1): 1461-1482, 2018. https://doi.org/10.18632/oncotarget.22879.
Wang, L., Kim, K., Parikh, S., Cadar, A.G., Bersell, K.R., He, H., Pinto, J.R., Kryshtal, D.O., Knollmann, B,C. Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes. J Mol Cell Cardiol. 114:320-327, 2018. doi: 10.1016/j.yjmcc.2017.12.002.
2017
Wang, L., Kryshtal, D.O., Kim, K., Parikh, S., Cadar, A.G., Bersell, K.R., He, H., Pinto, J.R., Knollmann, B.C. Myofilament Calcium-Buffering Dependent Action Potential Triangulation in Human-Induced Pluripotent Stem Cell Model of Hypertrophic Cardiomyopathy. J Am Coll Cardiol. 70(20):2600-2602, 2017. doi: 10.1016/j.jacc.2017.09.033.
Baxley, T., Johnson, D., Pinto, J.R., Chalovich, J.M. Troponin C mutations partially stabilize the active state of regulated actin and fully stabilize the active state when paired with D14 TnT. Biochemistry 56(23): 2928-2937, 2017. doi: 10.1021/acs.biochem.6b01092.
Bollen, I.A.E., Schuldt, M., Harakalova, M., Vink, A., Asselbergs, F.W., Pinto, J.R., Krüger, M., Kuster, D.W.D., Van der Velden, J. Genotype-specific pathogenic effects in human dilated cardiomyopathy. J. Physiol. 595(14): 4677-4693, 2017. doi: 10.1113/JP274145.
Dossat, A.M., Sanchez-Gonzalez, M.A., Koutnik, A.P., Leitner, S., Ruiz, E.L., Griffin, B., Rosenberg, J.T., Grant, S.C., Fincham, F.D., Pinto, J.R., Kabbaj, M. Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy. FASEB J. 31(6): 2492-2506, 2017. doi: 10.1096/fj.201600955RR.
Kawai, M., Johnston, J.R., Karam, T., Wang, L., Singh, R.K., Pinto, J.R. Myosin Rod Hypophosphorylation and CB Kinetics in Papillary Muscles from a TnC-A8V KI Mouse Model. Biophys. J. (London) 112(8): 1726-1736, 2017. doi: http://dx.doi.org/10.1016/j.bpj.2017.02.045
Veltri, T., Landim-Vieira, M., Parvatiyar, M.S., Gonzalez-Martinez, D., Dieseldorff Jones, K.M., Michell, C.A., Dweck, D., Landstrom, A.P., Chase, P.B., Pinto, J.R. Hypertrophic cardiomyopathy cardiac Troponin C mutations defferentially affect slow skeletal and cardiac muscle regulation. Front. Physiol. April(8): 221, 2017. doi: 10.3389/fphys.2017.00221.
Veltri, T., de Oliveira, G.A., Bienkiewicz, E.A., Palhano, F.L., Marques, M.A., Moraes, A.H., Silva, J.L., Sorenson, M.M., Pinto, J.R. Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C. Sci Rep. Apr 6;7(1):691, 2017. doi: 10.1038/s41598-017-00777-6.
Pinto, J.R., Muller-Delp, J., Chase, P.B. Will you still need me (Ca2+ , TnT, and DHPR), will you still cleave me (calpain), when I'm 64? Aging Cell. Apr;16(2):202-204, 2017. doi: 10.1111/acel.12560
Marques, M.A., Pinto, J.R., Moraes, A.H., Iqbal, A., de Magalhães, M.T., Monteiro, J., Pedrote, M.M., Sorenson, M.M., Silva, J.L., de Oliveira, G.A. Allosteric transmission along a loosely structured backbone allows a cardiac Troponin C mutant to function with only one Ca2+ ion. J Biol Chem. Feb 10;292(6):2379-2394, 2017. doi: 10.1074/jbc.M116.765362.
2016
Badr, M.A., Pinto, J.R., Davidson, M.W., Chase, P.B. Fluorescent Protein-Based Ca2+ Sensor Reveals Global, Divalent Cation-Dependent Conformational Changes in Cardiac Troponin C. PLoS One. Oct 13;11(10):e0164222, 2016. doi: 10.1371/journal.pone.0164222
Sheng, J.J., Feng, HZ., Pinto, J.R., Wei, H., Jin, J.P. Increases of desmin and a-actinin in mouse cardiac myofibrils as a response to diastolic dysfunction. J Mol Cell Cardiol. Oct;99:218-229, 2016. doi: 10.1016/j.yjmcc.2015.10.035
Na, I., Kong, M.J., Straight, S., Pinto, J.R., Uversky, V.N. Troponins, intrinsic disorder, and cardiomyopathy. Biol Chem. Aug 1;397(8):731-51, 2016. doi: 10.1515/hsz-2015-0303
Zot, H.G., Hasbun, J.E., Michell, C.A., Landim-Vieira, M., Pinto, J.R. Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C. Arch Biochem Biophys. Jul 1;601:97-104, 2016. doi: 10.1016/j.abb.2016.03.011
2015
Figueiredo-Freitas, C., Dulce, R., Foster, M.W., Liang, J., Yamashita, A.M., Lima-Rosa, F.L., Thompson, W.J., Moseley, A.M., Hare, J.M., Nogueira, L., Sorenson, M.M., Pinto, J.R. S-nitrosylation of sarcomeric proteins depresses myofilament Ca2+ sensitivity in intact cardiomyocytes. Antioxid Redox Signal. Nov 1;23(13):1017-34, 2015. doi: 10.1089/ars.2015.6275
Martins, A.S., Parvatiyar, M.S., Feng, HZ., Bos, J.M., Gonzalez-Martinez, D., Vukmirovic, M., Turna, R.S., Sanchez-Gonzalez, M.A., Badger, C.D., Zorio, D.A., Singh, R.K., Wang, Y., Jin, J.P., Ackerman, M.J., Pinto, J.R. In vivo Analysis of Troponin C Knock-in (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene. Circ Cardiovasc Genet. Oct;8(5):653-64, 2015
Chang, A.N., Battiprolu, P.K., Cowley, P.M., Chen, G., Gerard, R.D., Pinto, J.R., Hill, J.A., Baker, A.J., Kamm, K.E., Stull, J.T. Constitutive Phosphorylation of Cardiac Myosin Regulatory Light Chain in vivo. J. Biol. Chem. 290(17):10703-16, 2015
Parvatiyar, M.S. and Pinto, J.R. Pathogenesis Associated with a Restrictive Cardiomyopathy Mutant in Cardiac Troponin T is Due to Reduced Protein Stability and Greatly Increased Myofilament Ca2+ Sensitivity. Biochim. Biophys. Acta. Feb;1850(2):365-72, 2015
2014
Chang, A.N., Greenfield, N.J., Singh, A., Potter, J.D., Pinto, J.R. Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin. Front. Physiol. Dec 2;5:460, 2014
Dweck, D., Sanchez-Gonzalez, M.A., Chang, A., Dulce, R., Badger, CD., Koutnik, A.P., Ruiz, E.L., Griffin, B., Liang, J., Kabbaj, M., Fincham, F., Hare, J., Overton, M.J., Pinto, J.R. Long term ablation of PKA-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a Knock-in mouse model of Hypertrophic Cardiomyopathy. J. Biol. Chem. 289:23097-23111, 2014
2013
Bai, F., Caster, H.M., Pinto, J.R., and Kawai, M. Functional properties of cardiomyopathy causing cTnT mutants I79N, DE96 and DK210: molecular pathogenesis study. Biophys. J. (London) 104(9): 1979-1988, 2013
Venkataraman, R., Baldo, M.P., Hwang, H., Veltri, T., Pinto, J.R., Baudenbacher, F.J., Knollmann, B.C. Myofilament calcium de-sensitization and contractile uncoupling with blebbistatin prevents ventricular tachycardia in mouse hearts with chronic myocardial infarction. J. Mol. Cell. Cardiol. 60C: 8-15, 2013
2012
Pinto, J.R., Gomes, A.V., Jones, M.A., Liang, J., Nguyen, S., Miller, T., Parvatiyar, M.S., and Potter, J.D. The Functional Properties of Human Slow Skeletal TnT Isoforms in the Cardiac Muscle Regulation. J. Biol. Chem. 287(44): 37362-70, 2012
Tao, G., Levay, A.K., Peacock, J.D., Huk, D.J., Both, S.N., Purcell, N.H., Pinto, J.R., Galantowicz, M.L., Koch, M., Lucchesi, P.A., Birk, D.E. and Lincoln J. Collagen XIV is important for growth and structural integrity of the myocardium. J. Mol. Cell. Cardiol. Nov;53(5):626-38, 2012
Parvatiyar, M., Landstrom, A., Figueiro-Freitas, C., Potter, J.D., Ackerman, M.J., Pinto, J.R. A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation. J. Biol. Chem. 287(38):31845-31855, 2012
Ueta, C.B., Oskouei, B.N., Olivares, E.L., Pinto, J.R., Correa, M.M., Simovic, G., Simonides, W.S., Hare, J.M., Bianco, A.C. Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice. Mol Endocrinol. May;26(5): 809-18, 2012
Wang, Y., Pinto, J.R., Sancho Solis, R., Dweck, D., Liang, J., Diaz-Perez, Z., Ge, Y., Walker, J.W., Potter, J.D. The Generation and Functional Characterization of Knock-In Mice Harboring the Cardiac-troponin I R21C Mutation Associated with Hypertrophic Cardiomyopathy. J. Biol. Chem. 287(3): 2156-2167, 2012
2011
Pinto, J.R., Siegfried, J.D., Parvatiyar, M.S., Li, D., Norton, N., Jones, M.A., Liang, J., Potter, J.D., Hershberger, R.E. Functional Characterization of TNNC1 Rare Variants Identified in Dilated Cardiomyopathy. J. Biol. Chem. 286(39): 34404-34412, 2011
Midde, K., Dumka, V., Pinto, J.R., Muthu, P., Marandos, P., Gryczynski, I., Gryczynski, Z., Potter, J.D., Borejdo, J. Myosin cross-bridges do not form precise rigor bonds in hypertrophic heart muscle carrying troponin T mutations. J Mol Cell Cardiol. Sep;51(3): 409-418, 2011
Pinto, J.R., Yang, S.W., Hitz, M.P., Parvatiyar, M.S., Jones, M.A., Liang, J., Victor, K., Talajic, M., Tremblay, N., Jaeggi, M., Andelfinger, G. and Potter, J.D. Fetal Cardiac Troponin Isoforms Rescue the Increased Ca2+ Sensitivity Produced by a Novel Double Deletion in Cardiac Troponin T Linked to Restrictive Cardiomyopathy. A Clinical, Genetic and Functional Approach. J. Biol. Chem. 286(23): 20901-20912, 2011
Pinto, J.R., Sousa, V.P. and Sorenson, M.M. Redox State of Troponin C Cysteine in the D/E Helix Alters the C-domain Affinity for the Thin Filament of Vertebrate Striated Muscle. BBA - Gen Subj. 1810(4): 391-397, 2011
Pinto, J.R., Reynaldo, D.P., Parvatiyar, M.S., Dweck, D., Liang, J., Jones, M.A., Sorenson, M.M. and Potter, J.D. Strong Crossbridges Potentiate the Ca2+ Affinity Changes Produced by HCM-Cardiac Troponin C Mutants in Myofilaments. A Fast Kinetic Approach. J. Biol. Chem. 286(2): 1005-1013, 2011
2010
Morales, A., Pinto, J.R., Siegfried, J.D., Li, D., Norton, N., Hofmeyer, M., Vallin, M., Morales, A.R., Potter, J.D. and Hershberger, R.E. Late onset sporadic dilated cardiomyopathy caused by a cardiac troponin T mutation. Clin. Trans. Sci. 3:219-226, 2010
Parvatiyar, M.S., Pinto, J.R., Liang, J.S. and Potter, J.D. Predicting Cardiomyopathic Phenotypes by Altering the Ca2+ Affinity of Cardiac Troponin C. J. Biol. Chem. 285(36): 27785-97, 2010
Li, Y., Charles, P.Y.J., Nan, C., Pinto, J.R., Wang, Y., Liang, J., Wu, G., Tian, J., Feng, H.Z., Potter, J.D., Jin, J.P. and Huang, X. Correcting diastolic dysfunction by desensitizing troponin in transgenic RCM mice. J. Mol. Cell. Card. 49: 402-411, 2010
Dweck, D., Reynaldo, D.P., Pinto, J.R. and Potter, J.D. A Dilated Cardiomyopathy Troponin C Mutation Lowers Contractile Force by Reducing Strong Myosin-Actin Binding. J. Biol. Chem. 285(23): 17371-17379, 2010
Parvatiyar, M.S., Pinto, J.R., Dweck, D. and Potter, J.D. Cardiac Troponin Mutations and Restrictive Cardiomyopathy. J. Biomed. Biotechnol. ID 350706, 2010
Willott, R.W., Gomes, A.V., Parvatiyar, M.S., Chang, A., Pinto, J.R. and Potter, J.D. Mutation in Troponin that Cause Hypertrophic, Dilated and Restrictive Cardiomyopathy: What Can We Learn About Thin Filament Function? J. Mol. Cell Card. 48: 882-892, 2010
2009
Wen, Y., Xu, Y., Wang, Y., Pinto, J.R., Potter, J.D. and Kerrick, W.G.L. Functional Effects of a Restrictive Cardiomyopathy linked Cardiac Troponin I mutation (R145W) in Transgenic Mice. J. Mol. Biol., 392(5): 1158-1167, 2009
Pinto, J.R., Parvatiyar, M.S., Jones, M.A., Liang, J., Ackerman, M.J. and Potter, J.D. A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy. J. Biol. Chem, 284(28): 19090-19100, 2009
Hershberger, R.E., Pinto, J.R., Parks, S.B., Kushner, J.D., Li, D., Ludwigsen, S., Cowan, J., Morales, A., Parvatiyar, M.S. and Potter, J.D. Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy. Circulation: Cardiovasc. Genet., 2: 306-313, 2009
2008
Baudenbacher, F., Schober, T., Pinto, J.R., Sidorov, V., Hilliard, F., Solaro, R.J., Potter, J.D. and Knollmann, B.C. Myofilament Calcium Sensitization Causes Susceptibility to Cardiac Arrhythmia in Mice. J. Clin. Invest., 188(12): 3893-3903, 2008
Wen, Y., Pinto, J.R., Xu, Y., Wang, Y., Wang, Y., Gomes, A.V., Potter, J.D. and Kerrick, W.G.L. Functional Consequences of a Cardiac Troponin I (R145G) Mutation Associated with Hypertrophic Cardiomyopathy in Transgenic Mice. J. Biol. Chem., 283(29): 20484-20494, 2008
Landstrom, A.P.*, Parvatiyar, M.S.*, Pinto, J.R.*, Marquardt, M.L., Bos, J.M., Tester, D.J., Ommen, S.R., Potter, J.D. and Ackerman, M.J. Molecular and Functional Characterization of Novel Hypertrophic Cardiomyopathy Susceptibility Mutations in TNNC1- Encoded Troponin C. J. Mol. Cell Card., 45: 281-288, 2008 (*Co-first author)
Pinto, J.R., Veltri, T. and Sorenson, M.M. Modulation of Troponin C Affinity for the Thin Filament by Different Types of Crossbridges in Skinned Skeletal Muscle. Pflugers Archive, 456: 1177-1187, 2008
Pinto, J.R., Parvatiyar, M.S., Jones, M.A., Liang, J. and Potter, J.D. A Troponin T Mutation that Causes Infantile Restrictive Cardiomyopathy Increases Ca2+ Sensitivity of Force Development and Impairs the Inhibitory Properties of Troponin. J. Biol. Chem. 283: 2156-2166, 2008
2006
Sousa, V.P., Pinto, J.R. and Sorenson, M.M. Ionic Interventions that Alter the Association of Troponin C C-domain with the Thin Filaments of Vertebrate Striated Muscle. Biochim. Biophys. Acta (Gen. Subj.) 1760: 272-282, 2006
Braga, C.A.C.A., Pinto, J.R., Valente, A.P., Silva, J.L., Sorenson, M.M., Foguel, D. and Suarez, M.C. Ca2+ and Mg2+ Binding to the Weak Sites of TnC C-domain Induces Exposure of a Large Hydrophobic Surface that Leads to Loss of TnC from the Thin Filament. Intl. J. Biochem. Cell Biol. 38: 110-122, 2006
2004
Costa, L.T., Pinto, J.R., Moraes, M.B., Bastos, G.G., Sorenson, M.M., Bisch, P.M. and Weissmüller, G. Chemical Treatment of Mica for Atomic Force Microscopy Can Affect Biological Sample Conformation. Biophys. Chem. 109: 63-71, 2004