Biosketch
Dr. Ren received her medical training in China and then undertook her Ph.D at Imperial College School of Medicine, London, UK. She joined Department of Biomedical Sciences, Florida State University College of Medicine in 2013.
Education
Post-Doctoral training, University of Nottingham and Edinburgh
Ph.D., Imperial College School of Medicine, London, UK. Major: Cell Biology
MPhil, Chinese Disease Control, Major: Immunology and Virology
M.D., Guiyang Medical School, Major: Medicine
Honors/Awards
2015. 100 Inspiring Women in STEM Award issue of INSIGHT into Diversity magazine
2008. Merit award, Rutgers University
2008-2013. Joyce and Les Goodman Scholar
1995-1999. British Royal Society Research Fellowship
Courses
“Immunology, Infection & Cancer” (GMS6001) Course for graduate students. Florida State University. 2024
“Neuroscience Methods” (PSB4400) Course for undergraduates. Florida State University. 2024
“Foundation of Clinical Physiology” (PAS 5025) Course for Physician Assistant Students. Florida State University College of Medicine. 2017 – present
"Systemic Physiology and Pathophysiology” (PAS 5028) Course for Physician Assistant Students. 2019 – present
“Special Topics in Biomedical Sciences” (GMS 6001). Course for graduate students. Florida State University College of Medicine. 2015 - present.
Research Focus
Dr. Yi Ren directs a group interested in the molecular cell biology of inflammation, especially macrophage function in CNS trauma and tumor progression.
Publications
Tuna R, Yi W, Cruz EC, Romero JP, Ren Y, Guan JJ, Li Y, Deng YF, Bluestein, Liu ZL, Sheriff J. Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation. Int. J. Mol. Sci. 2024, 25(9), 4800; doi:10.3390/ijms25094800
Wang X*, Cheng ZJ, Tai WJ, Shi MJ, Ayazi M, Liu Y, Sun L, Yu CY, Fan ZM, Guo B, He XJ, Sun DM, Young W, Ren Y.* Targeting foamy macrophages by manipulating ABCA1 expression to facilitate lesion healing in the injured spinal cord. Brain, Behavior, and Immunity. 2024 Apr 16:S0889-1591(24)00358-1. doi: 10.1016/j.bbi.2024.04.013.
Liu C, Chen X, Liu Y, Sun L,Yu ZB, Ren Y, Zeng CC and Li Y. Engineering Extracellular Matrix-bound Nanovesicles Secreted by Three-dimensional Human Mesenchymal Stem Cells. Advanced Healthcare Materials. 2023 Oct;12(27):e2301112. doi: 10.1002/adhm.202301112.
Poppell M, Hammel G and Ren Y*. Immune Regulatory Functions of Macrophages and Microglia in Central Nervous System Diseases. Int J Mol Sci. 2023 Mar 21;24(6):5925. doi: 10.3390/ijms24065925.
Li Z, Liang HF, Hu YY, Lu L, Zheng C, Fan YZ, Wu B, Zuo T, Luo XD, Zhang XC, Zeng Y, Liu Z, Zhou ZC, Yue ZY, Ren Y, Li Zhuo, Su QZ and Xu PY*. Gut bacterial profiles in Parkinson's disease: A systematic review. CNS Neurosci Ther. 2023 Jan ;29(1):140-157. doi: 10.1111/cns.13990. Epub 2022 Oct 25.
Vallega K, Bosco DB, Ren Y and Sang A*. Macrophage-Conditioned Media Promotes Adipocyte Cancer Association, Which in Turn Stimulates Breast Cancer Proliferation and Migration. Biomolecules. 2022, 12, 1757. https://doi.org/10.3390/biom12121757
Ayazi M, Zivkovic S, Hammel G, Stefanovic B and Ren Y*. Fibrotic Scar in CNS Injuries: From the Cellular Origins of Fibroblasts to the Molecular Processes of Fibrotic Scar Formation. Cells. 2022 Aug 2;11(15):2371. doi: 10.3390/cells11152371.
Hammel G, Zivkovic S, Ayazi M, and Ren Y*. Consequences and mechanisms of myelin debris uptake and processing by cells in the central nervous system. Cellular Immunology. 2022. 104591. Aug. doi.org/10.1016/j.cellimm.
Cheng WH, Kim S, Zivkovic S, Chung HY, Ren Y and Guan JJ*. Specific labelling of phagosome-derived vesicles in macrophages with a membrane dye delivered with microfabricated microparticles. Acta Biomater. 2022 Jan 19;S1742-7061(22)00036-8. doi: 10.1016/j.actbio.2022.01.028.
Liu Y, Hammel G, Shi MJ, Cheng ZJ, Zivkovic S, Wang XQ, Xu PY, He XJ, Guo B, Ren Y*, Zuo L*. Myelin debris stimulates NG2/CSPG4 expression in bone marrow-derived macrophages in the injured spinal cord. Front. Cellular Neurosci. 2021. 19;15:651827. doi: 10.3389/fncel.2021.651827.
Zivkovic S, Ayazi M, Hammel G, Ren Y*. For better or for worse: a look into neutrophils in traumatic spinal cord injury. Front. Cellular Neurosci. 2021. 22;15:648076. doi: 10.3389/fncel.2021.648076.
Peng J, Yi MH, Jeong H, McEwan PP, Zheng J, Wu G, Ganatra S, Ren Y, Richardson JR, Oh SB, Wu LJ*. The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury. Mol Brain. 2021 Jun 28;14(1):99. doi: 10.1186/s13041-021-00812-8.
Ou RY, Lv MF, Liu X, Lv JM, Zhao JD, Zhao Y, Li XY, Li WF, Zhao L, Li JR, Ren Y, Xu YS*. HPV16 E6 oncoprotein-induced upregulation of lncRNA GABPB1-AS1 facilitates cervical cancer progression by regulating miR519e-5p/Notch2 axis. FASEB J. 2020 Aug 26. doi: 10.1096/fj.202000762R.
Liu J, Zhao HQ, Zhang Q, Shi ZZ, Zhang YY, Zhao L, Ren Y, Ou RY, Xu YS*. Human papillomavirus type 16 E7 oncoprotein-induced upregulation of lysine-specific demethylase 5A promotes cervical cancer progression by regulating the microRNA-424-5p/suppressor of zeste 12 pathway. Exp Cell Res. 2020.10;396(1):112277.
Ou R, Lv J, Zhang Q, Lin F, Zhu L, Huang F, Li X, Li T, Zhao L, Ren Y, Xu YS*. circAMOTL1 Motivates AMOTL1 Expression to Facilitate Cervical Cancer Growth. Mol Ther Nucleic Acids. 2020. 6;19:50-60.
Li JH, Sun YB, Chen WY, Fan JJ, Li SH, Qu XL, Chen QK, Chen RL, Zhu DJ, Zhang JF, Wu ZG, Chi HG, Crawford S, Oorschot V, Puelles VG, Kerr PG, Ren Y, Nilsson SK, Christian M, Tang HY, Chen W, Bertram JF, Nikolic-Paterson DJ and Yu XQ. Smad4 Promotes Diabetic Nephropathy by Modulating Glycolysis and OXPHOS. EMBO Rep. 2020. 5;21(2):e48781.
Jiang M, Fan J, Qu X, Li S, Nilsson SK, Sun YBY, Chen Y, Yu D, Liu D, Liu BC, Tang M, Chen W, Ren Y, Nikolic-Paterson DJ, Jiang X, Li J and Yu X*. Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy. Front. Pharmacol. 2019;10:880.
Ding Z, Zhu H, Mo L, Li X, Xu R, Li T, Zhao L, Ren Y, Xu Y, Ou R*. FLT3L and Granulocyte Macrophage Colony-Stimulating Factor Enhance the Anti-Tumor and Immune Effects of an HPV16 E6/E7 Vaccine. Aging (Albany NY). 2019 Dec 24;11(24):11893-11904.
Xu Y, Zhou W, Zhang C, Liu X, Lv J, Li X, Zhao L, Li W, Li J, Ren Y, Ou R*. Long Non-Coding RNA RP11-552M11.4 Favors Tumorigenesis and Development of Cervical Cancer via Modulating miR-3941/ATF1 Signaling. Int J Biol Macromol. 2019 Jun 1;130:24-33.
Ban Y, Dong WJ, Zhang LX, Zhou T, Altiti AS, Ali K, Mootoo D, Blaho VA, Hla T, Ren Y* and Ma XJ*. Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Front. Immunol. 2019. 19;10:404.
Ou R, Zhu L, Zhao L, Li W, Tao F, Lu Y, He Q, Li J, Ren Y, Xu Y*. HPV16 E7-induced Upregulation of KDM2A Promotes Cervical Cancer Progression by Regulating miR-132-radixin Pathway. J Cell Physiol. 2019 Mar;234(3):2659-2671.
Zhou T, Zheng YM*, Sun L, Badea SR, Jin YH, Liu Y, Rolfe A, Sun H, Wang X, Cheng ZJ, Huang ZS, Zhao N, Sun X, Li JH, Fan JQ, Lee C, Megraw M, Wu WT, Wang GX* and Ren Y*. Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury. Nature Neurosci. 2019. 22(3):421-435 (Highlighted at Faculty 1000, DOI: 10.3410/f.734888686.793558531)
Zhou QS, Xiang HK, Li A, Lin W, Huang ZS, Guo JX, Wang PJ, Chi YJ, Xiang K, Xu YS, Zhou LB, So KF, Chen XM, Sun X, Ren Yi*. Activating Adiponectin Signaling with Exogenous AdipoRon Reduces Myelin Lipid Accumulation and Suppresses Macrophage Recruitment after Spinal Cord Injury. J. Neurotrauma. 2019. 19;36(6):903-918.
Lang J, Cheng Y, Rolfe A, Hammack C, Vera D, Kyle K, Wang J, Meissner TB, Ren Y, Cowan C, Tang H*. An hPSC-Derived Tissue-Resident Macrophage Model Reveals Differential Responses of Macrophages to ZIKV and DENV Infection. Stem Cell Reports. 2018. 11:1-15.
Rolfe A, Bosco D, Broussard E and Ren Y*. In Vitro Phagocytosis of Myelin Debris by Bone Marrow-Derived Macrophages. JoVE. 2017 Dec 30;(130). doi: 10.3791/56322.
Gu R, Sun X, Chi YJ, Zhou QS, Xiang HK, Bosco D, Lai XH, Qin CX, So KF, Ren Y* and Chen XM*. Integrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth. Sci. Reports. 2017. 25;7(1):6455.
Wang ZB, Xia JF, Hoang PT, Sun L, Luo S, Cheng ZJ, Ren Y, Liu T and Guan JJ*. Fabrication of carbon nanotube-laden microdevices for Raman labeling of macrophages. Biomed. Phy. & Eng. Exp. 2017. 3. Doi.org/10.1088/2057-1976/aa6207.
Cheng ZJ, Bosco DB, Sun L, Chen XM, Xu YS, Tai WJ, Didier R, Li JH, Fan JQ, He XJ and Ren Y*. Neural stem cell-conditioned medium suppresses inflammation and promotes spinal cord injury recovery. Cell transplantation. 2017. 26:469-482.
Sun X, Shao H, Xiang K, Yan Y, Yu X, Li D, Wu W, Zhou L, So K-F, Ren Y, Ramakrishna S, Li A, He L*. Poly (dopamine)-modified carbon nanotube multilayered film and its effects on macrophages. Carbon. 2017. 113, 176-191
Xia JF, Wang ZB, Yan YW, Cheng ZJ, Sun L, Li Y, Ren Y and Guan JJ*. Catalase-Laden Microdevices for Cell-Mediated Enzyme Delivery. Langmuir. 2016. 32:13386-13393
He, GR, Zhang HZ, Chen CD, Lai XH, Ren Y* and Chen XM*. Adoptive transfer of glypican-3 peptide-specific CD8 T lymphocytes causes regression of testicular yolk sac tumor in mice. Int. J. Innovat. Res. Med. Sci. 2016. 1:345-353.
Cheng ZJ, Zhu W, Cao K, Wu F, Li J, Wang G, Li H, Lu M, Ren Y* and He XJ*. Anti-Inflammatory Mechanism of Neural Stem Cell Transplantation in Spinal Cord Injury. Int. J. Mol. Sci. 2016. 17: pii: E1380.
Sun X, Jones Z, Chen XM, Zhou LB, So KF and Ren Y*. Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship. J. Neuroinflammation. 2016. 6;13(1):260.
Jones Z and Ren Y*. Sphingolipids in spinal cord injury. Int. J. Physiol. Pathophysiol. Pharmacol. 2016;8(2):52-69.
Gu N, Peng J, Murugan M, Wang X, Eyo UB, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H, Wu LJ*. Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury. Cell Rep. 2016. pii: S2211-1247(16)30758-6.
Rolfe AJ, Bosco DB, Wang JY, Nowakowski RS, Fan JQ and Ren Y*. Bioinformatic Analysis Reveals the Expression of Unique Transcriptomic Signatures in Zika Virus Infected human Neural Stem Cells. Cell & Bioscience. 2016. 6:42. DOI 10.1186/s13578-016-0110-x.
Guo L, Rolfe AJ, Wang X, Tai W, Cheng Z, Cao K, Chen X, Xu Y, Sun D, Li J, He X, Young W, Fan J, Ren Y*. Rescuing macrophage normal function in spinal cord injury with embryonic stem cell conditioned media. Mol. Brain. 2016. 9(1): 48.
Lai XH, Zhao LF, Chen XM and Ren Y. Rapid Identification and Characterization of Francisella by Molecular Biology and Other Techniques. Open Micob. J. 2016. 10:64-77.
Sun YBY, Qu XL, Howard V, Dai L, Jiang XY, Ren Y, Caruana G, Bertram JF, Sleeman M, Li J*. Smad3 deficiency protects mice from obesity-induced podocyte injury which precedes insulin resistance. Kidney International. 2015. doi: 10.1038/ki.2015.121. PMID: 25945408
Lai XH, Xu YS, Chen XM and Ren Y*. Macrophage cell death upon intracellular bacterial infection. Macrophage. 2015. 2:e779. PMID: 26690967
Wang Xi, Cao K, Sun X, Chen YX, Duan ZX, Sun Li, Guo L, Bai P, Sun DM, Fan JQ, He XJ, Young W and Ren Y*. Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris. Glia. 2015. 63: 635–651. PMID: 25452166
Yao XM, Chan ZL, Shen DL, Zhou QH, Huang SS, Cai ZR, Tang YL, Wang M, Ren Y, Lai XH, and Chen XM*. Risk factors for pediatric intussusception complicated by loss of intestine viability in China from June 2009 to May 2014: a retrospective study. Ped. Surg. Int. 2015. 31(2):163-6. PMID: 25524017
Qu X, Jiang M, Sun YB, Jiang X, Fu P, Ren Y, Wang D, Dai L, Caruana G, Bertram JF, Nikolic-Paterson DJ, Li J*. The Smad3/Smad4/CDK9 complex promotes renal fibrosis in mice with unilateral ureteral obstruction. Kidney Int. 2015. 88:1323-1335.
Zhou X, He XJ and Ren Y*. Function of microglia and macrophages in secondary damage after spinal cord injury. Neural Regeneration Research. 2014. 9:1787-1795. Invited review. PMID: 25422640
Zhang J, Sun X, Zheng S, Liu X1 Jin J, Ren Y, Luo J*. Myelin Basic Protein Induces Neuron-Specific Toxicity by Directly Damaging the Neuronal Plasma Membrane. Plos ONE. 2014. 9(9): e108646. PMID: 25255088
Chen TX, Wang Xi, Guo L, Wu MM, Duan ZX, Lv J, Tai WJ, Renganathan H, Didier R, Li JH, Sun DM, Chen XM, He XJ, Fan JQ, Young W and Ren Y*. Embryonic stem cells promoting macrophage survival and function are crucial for teratoma development. Frontiers in Immunology. 2014. 5:1-16. PMID: 25071759
Qu X, Li Xl, Zheng YW, Ren Y, Puelles VG, Caruana G, Nikolic-Paterson D, and Li JH*. Regulation of Renal Fibrosis by Smad3 Thr388 Phosphorylation. Am. J. Path. 2014. 184:944-952. PMID: 24485922
Zhang XJ, Chen LW, Wang YZ, Ding YX, Peng ZW, Duan L, Ju G, Ren Y* and Wang X*. Macrophage Migration Inhibitory Factor Promotes Proliferation and Neuronal Differentiation of Neural Stem/Precursor Cells through Wnt/β-Catenin Signal Pathway. Int. J. Biol. Sci. 2013. 9:1108-1120. PMID: 24339732
Ren Y* and Young W. Managing inflammation after spinal cord injury through manipulation of macrophage function. Neural Plasticity. 2013. Vol. 2013: Article ID 945034. PMCID: PMC3833318. Invited review. PMID: 24288627
Wang X, Fan JQ, Lin, L, Cao K, Duan ZX, Chen TX, Zhang XJ, Shao CS, Tadmori I, Li TY, Sun DM, Zheng SS, Meinhardt A, Young W, Bucala R and Ren Y*. MIF Produced by Bone Marrow-Derived Macrophages Contributes to Teratoma Progression after Embryonic Stem Cell Transplantation. Cancer Res. 2012. 71:2867-2878. PMID: 22461508
Ren Y*. Peroxisome proliferator-activator receptor γ: a link between macrophage CD36 and inflammation in malaria infection. PPAR Res. 2012 Jan. Volume 2012:640769. Invited review. PMID: 22287954
Zhu ZZ, Kremer P, Tadmori I, Ren Y, Sun DM, He XJ and Young W*. Lithium Suppresses Astrogliogenesis by Neural Stem and Progenitor Cells by Inhibiting STAT3 Pathway Independently of Glycogen Synthase Kinase 3-b. PloS ONE. 2011. 6(9): e23341. PMID: 21931595
Shi LM, et al. The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nature Biotechnology. 2010. 28 (8): 827-838. PMID: 20676074
Sun X, Wang X, Chen TX, Li TY, Cao K, Lu A, Chen YX, Sun DM, Luo JH, Fan JQ, Young W and Ren Y*. Myelin activates FAK/Akt/NF-κB pathways and provokes CR3-dependent inflammatory response. PLoS ONE. 2010. 5(2):e9380. PMID: 20186338
Li W, Xie Y, Sun R, Liu Q, Young J, Yu WY, Che CM, Tam P and Ren Y*. Inhibition of Akt sensitizes neuroblastoma cells to gold(III) porphyrin 1a, a novel anti-tumor drug induced apoptosis and growth inhibition. British J. Cancer. 2009. 101:342-349. PMID: 19550420
Xie Y, Fan JQ, Chen JH, Huang FP, Cao B, Tam PKH and Ren Y*. A novel function for dendritic cell: clearance of VEGF via VEGF receptor-1. Biochem. Biophys. Res. Commun. 2009. 380: 243-248. PMID: 19167346
Ren Y*, Xie Y, Jiang GP, Fan JQ, Yeung J, Li W, Tam T and Savill J. Apoptotic cells protect mice against LPS-induced shock. J. Immunol. 2008. 180: 4978-4985. PMID: 18354223
Xie Y, Chan HM, Fan JQ, Chen YX, Young J, Li W, Miao XP, Yuan ZW, Wang HM, Tam P and Ren Y*. Involvement of Visinin Like Protein-1 (VSNL-1) in Regulating Proliferative and Invasive Properties of Neuroblastoma. Carcinogenesis. 2007. 28(10):2122-30. PMID: 17615261
Fan JQ and Ren Y. Statistical Analysis of DNA Microarray Data in Cancer Research. Clin. Cancer Res. 2006. 12(15):4469-4473. PMID: 16899590
Ren Y*, Chan HM, Fan JQ, Chen YX, Xie Y, Li W, Jiang GP, Liu Q, Meinhardt A and Tam P. Inhibition of Tumor Growth and Metastasis in vitro and in vivo by Targeting Macrophage Migration Inhibitory Factor in Human Neuroblastoma. Oncogene. 2006 Jun 15; 25(25):3501-8. PMID: 16449971
Fan JQ, Chen YX, Chan HM, Tam P and Ren Y*. Removing intensity effects and identifying significant genes for Affymetrix arrays in MIF-suppressed neuroblastoma cells. Proc. Natl. Acad. Sci. USA. 2005 Dec. 102 (49):17751-17756. PMID: 16314559
Ren Y*, Cao B, Law S, Xie Y, Lee PY, Cheung L, Chen YX, Huang X, Chan HM, Zhao P, Luk L, Vande Woude G and John Wong. Hepatocyte Growth Factor Promotes Cancer Cell Migration and Angiogenic Factors expression: A Prognostic Marker of Human Esophageal Squamous Cell Carcinomas. Clin. Cancer Res. 2005.Sep. 11(17): 6190-6197. PMID: 16144920
Ren Y*, Law S, Huang X, Lee PY, Li Z, Bacher M, Srivastava G and Wong J. Macrophage Migration Inhibitory Factor Stimulates Angiogenic Factors Expression, Correlates with Differentiation and Lymph Node Status in Patients with Esophageal Squamous Cell Carcinoma. Ann. Surg. 2005. 242 (1): 55-63. PMID: 15973102
Fan JQ, Huang T, Peng H and Ren Y. Semilinear high-dimensional model for normalization of microarray data: a theoretical analysis and partial consistency. J Am Stat Asso. 2005. Sep. 808-813.
Ren Y*, Lin CL, Li Z, Chen YX, Huang X, Lui V, Nicholls J, Lan HY and Tam P. Up-regulation of macrophage migration inhibitory factor in infants with acute neonatal necrotizing enterocolitis. Histopathology. 2005. 46(6):659-67. PMID: 15910597
He QY, Zhu R, Ren Y, Chiu JF and Tam P*. Serological Protein Profiling of Neuroblastoma by ProteinChip SELDI-TOF Technology. J. Cell Biochem. 2005. 95(1):165-72. PMID: 15759280
Ren Y*, He QY, Fan JQ, Jones B, Zhou Y, Xie Y, Cheung CY, Wu A, Chiu JF, Peiris JSM and Tam P. The Use of Proteomics in the Discovery of Serum Biomarkers from Patients with Severe Acute Respiratory Syndrome (SARS). Proteomics. 2004 Nov; 4(11):3477-84. PMID: 15378763
Fan JQ, Tam P, Vande Woude G and Ren Y*. Normalization and significant analysis of cDNA microarrays using within-array replications applied to tumor cells response to MIF. Proc. Natl. Acad. Sci. USA. 2004. 101 (5): 1135-1140. PMID: 14739336
Li Z, Ren Y, Lin SX, Liang YJ and Liang HZ. Association of E-cadherin and beta-catenin with metastasis in nasopharyngeal carcinoma. Chin Med J. 2004. 117(8):1232-9. PMID: 15361301
Ren Y*, Chen HM, Li Z, Lin CL, Nicholls J, Chen ZF, Lee PY, Lui V, Bacher M and Tam P. Up-regulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma. Oncogene. 2004 23(23):4146-54. PMID: 15064733
Li Z, Ren Y, Wu QC, Lin SX, Liang YJ and Liang HZ. Macrophage migration inhibitory factor enhances neoplastic cell invasion by inducing the expression of matrix metalloproteinase 9 and interleukin-8 in nasopharyngeal carcinoma cell lines. Chin Med J. 2004. 117(1):1017-14. PMID: 14733785
Ren Y*, Poon RTP, Tsui HT, Li Z, Lau C, Yu WC and Fan ST. Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinico-pathological features and prognosis. Clin. Cancer Res. 2003 Dec 9: 5996-6001. PMID: 14676125
Ren Y, Tang JL, MoK T, Chan AWK, Wu A and Lau CS*. Increased apoptotic blood neutrophils and macrophages and decreased clearance of apoptotic neutrophils in systemic lupus erythematosus. Arthritis & rheumatism. 2003 Oct 48 (10): 2888-97. PMID: 14558095
Ren Y*, Tsui HT, Poon RTP, Li Z, Chen YX, Lau C, Bacher M and Fan ST. Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma. Int. J. Cancer. 2003. 107; 22-29. PMID: 12925952
Lo LL, WF, Lee TH, Ren Y, Hwang SL, Cheng YF, Chen CL, Chang YS, Lee SP, Rickinson AB, Tam P*. Immunization with Epstein-Barr Virus (EBV) peptide-pulsed dendritic cells induces functional CD8+ T cell immunity and can lead to tumor regression in patients with EBV-positive nasopharyngeal carcinoma. Cancer Res. 2002 Dec 1;62(23):6952-8. PMID: 12460912
Ren Y, Stuart L, Lindberg FP, Rosenkranz AR, Chen Y, Mayadas TN and Savill J*. Nonphlogistic clearance of late apoptotic neutrophils by macrophages: efficient phagocytosis independent of b2 intergrins. J. Immunol. 2001 April; 166: 4743-4750. PMID: 11254736
Harper L, Ren Y, Savill J, Adu D, Savage CO*. Antineutrophil cytoplasmic antibodies induce superoxide-dependent dyregulation of primed neutrophil apoptosis and clearance by macrophages. Am J. Path. 2000 July; 157(1): 211-220. PMID: 10880391
Zhuang JG, Ren Y, Snowden RT, Zhu H, Gogvadze V, Savill J, and Cohen GM*. Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of apoptotic program. J. Biol. Chem. 1998; 273(25): 1528-32. PMID: 9624155
Ren Y, Savill J*. Apoptosis: The importance of being eaten. Cell Death. Differ.1998; 5(7): 563-8. PMID: 10200510
Navazo MDP, Daviet L, Savill J, Ren Y Leung LL, and McGregor JL*. Identification of a domain (155-183) on CD36 implied in the phagocytosis of apoptotic neutrophils. J. Biol. Chem.1996; 271(26): 1538-85. PMID: 8663130
Ren Y, Silverstein RL, Allen J and Savill J*. CD36 gene-transfer confers capacity for phagocytosis of cells undergoing apoptosis. J. Exp. Med. 1995; 181(5): 1857-62. PMID: 7536797
Ren Y, Savill J*. Proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergoing apoptosis. J. Immunol. 1995; 154(5): 2366-74. PMID: 7532668
Savill J*, Hogg N, Ren Y, and Haslett C*. Thrombospondin co-operates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J. Clin. Invest. 1992; 90: 1513-22. PMID: 1383273
Savill J*, Smith J, Sarraf C, Ren Y, Abbott F and Rees A*. Glomerular mesangial cells and inflammatory macrophages ingest neutrophils undergoing apoptosis. Kidney Int. 1992: 42: 924-36. PMID: 1333549
Book Chapter:
Yi Ren. The role of MIF on tumorigenicity of embryonic stem cells. In: The MIF Handbook. R. Bucala. Ed. World Sci. 305-318, 2012.
Dr. Ren received her medical training in China and then undertook her Ph.D at Imperial College School of Medicine, London, UK. She joined Department of Biomedical Sciences, Florida State University College of Medicine in 2013.
Post-Doctoral training, University of Nottingham and Edinburgh
Ph.D., Imperial College School of Medicine, London, UK. Major: Cell Biology
MPhil, Chinese Disease Control, Major: Immunology and Virology
M.D., Guiyang Medical School, Major: Medicine
2015. 100 Inspiring Women in STEM Award issue of INSIGHT into Diversity magazine
2008. Merit award, Rutgers University
2008-2013. Joyce and Les Goodman Scholar
1995-1999. British Royal Society Research Fellowship
“Immunology, Infection & Cancer” (GMS6001) Course for graduate students. Florida State University. 2024
“Neuroscience Methods” (PSB4400) Course for undergraduates. Florida State University. 2024
“Foundation of Clinical Physiology” (PAS 5025) Course for Physician Assistant Students. Florida State University College of Medicine. 2017 – present
"Systemic Physiology and Pathophysiology” (PAS 5028) Course for Physician Assistant Students. 2019 – present
“Special Topics in Biomedical Sciences” (GMS 6001). Course for graduate students. Florida State University College of Medicine. 2015 - present.
Dr. Yi Ren directs a group interested in the molecular cell biology of inflammation, especially macrophage function in CNS trauma and tumor progression.
Tuna R, Yi W, Cruz EC, Romero JP, Ren Y, Guan JJ, Li Y, Deng YF, Bluestein, Liu ZL, Sheriff J. Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation. Int. J. Mol. Sci. 2024, 25(9), 4800; doi:10.3390/ijms25094800
Wang X*, Cheng ZJ, Tai WJ, Shi MJ, Ayazi M, Liu Y, Sun L, Yu CY, Fan ZM, Guo B, He XJ, Sun DM, Young W, Ren Y.* Targeting foamy macrophages by manipulating ABCA1 expression to facilitate lesion healing in the injured spinal cord. Brain, Behavior, and Immunity. 2024 Apr 16:S0889-1591(24)00358-1. doi: 10.1016/j.bbi.2024.04.013.
Liu C, Chen X, Liu Y, Sun L,Yu ZB, Ren Y, Zeng CC and Li Y. Engineering Extracellular Matrix-bound Nanovesicles Secreted by Three-dimensional Human Mesenchymal Stem Cells. Advanced Healthcare Materials. 2023 Oct;12(27):e2301112. doi: 10.1002/adhm.202301112.
Poppell M, Hammel G and Ren Y*. Immune Regulatory Functions of Macrophages and Microglia in Central Nervous System Diseases. Int J Mol Sci. 2023 Mar 21;24(6):5925. doi: 10.3390/ijms24065925.
Li Z, Liang HF, Hu YY, Lu L, Zheng C, Fan YZ, Wu B, Zuo T, Luo XD, Zhang XC, Zeng Y, Liu Z, Zhou ZC, Yue ZY, Ren Y, Li Zhuo, Su QZ and Xu PY*. Gut bacterial profiles in Parkinson's disease: A systematic review. CNS Neurosci Ther. 2023 Jan ;29(1):140-157. doi: 10.1111/cns.13990. Epub 2022 Oct 25.
Vallega K, Bosco DB, Ren Y and Sang A*. Macrophage-Conditioned Media Promotes Adipocyte Cancer Association, Which in Turn Stimulates Breast Cancer Proliferation and Migration. Biomolecules. 2022, 12, 1757. https://doi.org/10.3390/biom12121757
Ayazi M, Zivkovic S, Hammel G, Stefanovic B and Ren Y*. Fibrotic Scar in CNS Injuries: From the Cellular Origins of Fibroblasts to the Molecular Processes of Fibrotic Scar Formation. Cells. 2022 Aug 2;11(15):2371. doi: 10.3390/cells11152371.
Hammel G, Zivkovic S, Ayazi M, and Ren Y*. Consequences and mechanisms of myelin debris uptake and processing by cells in the central nervous system. Cellular Immunology. 2022. 104591. Aug. doi.org/10.1016/j.cellimm.
Cheng WH, Kim S, Zivkovic S, Chung HY, Ren Y and Guan JJ*. Specific labelling of phagosome-derived vesicles in macrophages with a membrane dye delivered with microfabricated microparticles. Acta Biomater. 2022 Jan 19;S1742-7061(22)00036-8. doi: 10.1016/j.actbio.2022.01.028.
Liu Y, Hammel G, Shi MJ, Cheng ZJ, Zivkovic S, Wang XQ, Xu PY, He XJ, Guo B, Ren Y*, Zuo L*. Myelin debris stimulates NG2/CSPG4 expression in bone marrow-derived macrophages in the injured spinal cord. Front. Cellular Neurosci. 2021. 19;15:651827. doi: 10.3389/fncel.2021.651827.
Zivkovic S, Ayazi M, Hammel G, Ren Y*. For better or for worse: a look into neutrophils in traumatic spinal cord injury. Front. Cellular Neurosci. 2021. 22;15:648076. doi: 10.3389/fncel.2021.648076.
Peng J, Yi MH, Jeong H, McEwan PP, Zheng J, Wu G, Ganatra S, Ren Y, Richardson JR, Oh SB, Wu LJ*. The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury. Mol Brain. 2021 Jun 28;14(1):99. doi: 10.1186/s13041-021-00812-8.
Ou RY, Lv MF, Liu X, Lv JM, Zhao JD, Zhao Y, Li XY, Li WF, Zhao L, Li JR, Ren Y, Xu YS*. HPV16 E6 oncoprotein-induced upregulation of lncRNA GABPB1-AS1 facilitates cervical cancer progression by regulating miR519e-5p/Notch2 axis. FASEB J. 2020 Aug 26. doi: 10.1096/fj.202000762R.
Liu J, Zhao HQ, Zhang Q, Shi ZZ, Zhang YY, Zhao L, Ren Y, Ou RY, Xu YS*. Human papillomavirus type 16 E7 oncoprotein-induced upregulation of lysine-specific demethylase 5A promotes cervical cancer progression by regulating the microRNA-424-5p/suppressor of zeste 12 pathway. Exp Cell Res. 2020.10;396(1):112277.
Ou R, Lv J, Zhang Q, Lin F, Zhu L, Huang F, Li X, Li T, Zhao L, Ren Y, Xu YS*. circAMOTL1 Motivates AMOTL1 Expression to Facilitate Cervical Cancer Growth. Mol Ther Nucleic Acids. 2020. 6;19:50-60.
Li JH, Sun YB, Chen WY, Fan JJ, Li SH, Qu XL, Chen QK, Chen RL, Zhu DJ, Zhang JF, Wu ZG, Chi HG, Crawford S, Oorschot V, Puelles VG, Kerr PG, Ren Y, Nilsson SK, Christian M, Tang HY, Chen W, Bertram JF, Nikolic-Paterson DJ and Yu XQ. Smad4 Promotes Diabetic Nephropathy by Modulating Glycolysis and OXPHOS. EMBO Rep. 2020. 5;21(2):e48781.
Jiang M, Fan J, Qu X, Li S, Nilsson SK, Sun YBY, Chen Y, Yu D, Liu D, Liu BC, Tang M, Chen W, Ren Y, Nikolic-Paterson DJ, Jiang X, Li J and Yu X*. Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy. Front. Pharmacol. 2019;10:880.
Ding Z, Zhu H, Mo L, Li X, Xu R, Li T, Zhao L, Ren Y, Xu Y, Ou R*. FLT3L and Granulocyte Macrophage Colony-Stimulating Factor Enhance the Anti-Tumor and Immune Effects of an HPV16 E6/E7 Vaccine. Aging (Albany NY). 2019 Dec 24;11(24):11893-11904.
Xu Y, Zhou W, Zhang C, Liu X, Lv J, Li X, Zhao L, Li W, Li J, Ren Y, Ou R*. Long Non-Coding RNA RP11-552M11.4 Favors Tumorigenesis and Development of Cervical Cancer via Modulating miR-3941/ATF1 Signaling. Int J Biol Macromol. 2019 Jun 1;130:24-33.
Ban Y, Dong WJ, Zhang LX, Zhou T, Altiti AS, Ali K, Mootoo D, Blaho VA, Hla T, Ren Y* and Ma XJ*. Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Front. Immunol. 2019. 19;10:404.
Ou R, Zhu L, Zhao L, Li W, Tao F, Lu Y, He Q, Li J, Ren Y, Xu Y*. HPV16 E7-induced Upregulation of KDM2A Promotes Cervical Cancer Progression by Regulating miR-132-radixin Pathway. J Cell Physiol. 2019 Mar;234(3):2659-2671.
Zhou T, Zheng YM*, Sun L, Badea SR, Jin YH, Liu Y, Rolfe A, Sun H, Wang X, Cheng ZJ, Huang ZS, Zhao N, Sun X, Li JH, Fan JQ, Lee C, Megraw M, Wu WT, Wang GX* and Ren Y*. Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury. Nature Neurosci. 2019. 22(3):421-435 (Highlighted at Faculty 1000, DOI: 10.3410/f.734888686.793558531)
Zhou QS, Xiang HK, Li A, Lin W, Huang ZS, Guo JX, Wang PJ, Chi YJ, Xiang K, Xu YS, Zhou LB, So KF, Chen XM, Sun X, Ren Yi*. Activating Adiponectin Signaling with Exogenous AdipoRon Reduces Myelin Lipid Accumulation and Suppresses Macrophage Recruitment after Spinal Cord Injury. J. Neurotrauma. 2019. 19;36(6):903-918.
Lang J, Cheng Y, Rolfe A, Hammack C, Vera D, Kyle K, Wang J, Meissner TB, Ren Y, Cowan C, Tang H*. An hPSC-Derived Tissue-Resident Macrophage Model Reveals Differential Responses of Macrophages to ZIKV and DENV Infection. Stem Cell Reports. 2018. 11:1-15.
Rolfe A, Bosco D, Broussard E and Ren Y*. In Vitro Phagocytosis of Myelin Debris by Bone Marrow-Derived Macrophages. JoVE. 2017 Dec 30;(130). doi: 10.3791/56322.
Gu R, Sun X, Chi YJ, Zhou QS, Xiang HK, Bosco D, Lai XH, Qin CX, So KF, Ren Y* and Chen XM*. Integrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth. Sci. Reports. 2017. 25;7(1):6455.
Wang ZB, Xia JF, Hoang PT, Sun L, Luo S, Cheng ZJ, Ren Y, Liu T and Guan JJ*. Fabrication of carbon nanotube-laden microdevices for Raman labeling of macrophages. Biomed. Phy. & Eng. Exp. 2017. 3. Doi.org/10.1088/2057-1976/aa6207.
Cheng ZJ, Bosco DB, Sun L, Chen XM, Xu YS, Tai WJ, Didier R, Li JH, Fan JQ, He XJ and Ren Y*. Neural stem cell-conditioned medium suppresses inflammation and promotes spinal cord injury recovery. Cell transplantation. 2017. 26:469-482.
Sun X, Shao H, Xiang K, Yan Y, Yu X, Li D, Wu W, Zhou L, So K-F, Ren Y, Ramakrishna S, Li A, He L*. Poly (dopamine)-modified carbon nanotube multilayered film and its effects on macrophages. Carbon. 2017. 113, 176-191
Xia JF, Wang ZB, Yan YW, Cheng ZJ, Sun L, Li Y, Ren Y and Guan JJ*. Catalase-Laden Microdevices for Cell-Mediated Enzyme Delivery. Langmuir. 2016. 32:13386-13393
He, GR, Zhang HZ, Chen CD, Lai XH, Ren Y* and Chen XM*. Adoptive transfer of glypican-3 peptide-specific CD8 T lymphocytes causes regression of testicular yolk sac tumor in mice. Int. J. Innovat. Res. Med. Sci. 2016. 1:345-353.
Cheng ZJ, Zhu W, Cao K, Wu F, Li J, Wang G, Li H, Lu M, Ren Y* and He XJ*. Anti-Inflammatory Mechanism of Neural Stem Cell Transplantation in Spinal Cord Injury. Int. J. Mol. Sci. 2016. 17: pii: E1380.
Sun X, Jones Z, Chen XM, Zhou LB, So KF and Ren Y*. Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship. J. Neuroinflammation. 2016. 6;13(1):260.
Jones Z and Ren Y*. Sphingolipids in spinal cord injury. Int. J. Physiol. Pathophysiol. Pharmacol. 2016;8(2):52-69.
Gu N, Peng J, Murugan M, Wang X, Eyo UB, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H, Wu LJ*. Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury. Cell Rep. 2016. pii: S2211-1247(16)30758-6.
Rolfe AJ, Bosco DB, Wang JY, Nowakowski RS, Fan JQ and Ren Y*. Bioinformatic Analysis Reveals the Expression of Unique Transcriptomic Signatures in Zika Virus Infected human Neural Stem Cells. Cell & Bioscience. 2016. 6:42. DOI 10.1186/s13578-016-0110-x.
Guo L, Rolfe AJ, Wang X, Tai W, Cheng Z, Cao K, Chen X, Xu Y, Sun D, Li J, He X, Young W, Fan J, Ren Y*. Rescuing macrophage normal function in spinal cord injury with embryonic stem cell conditioned media. Mol. Brain. 2016. 9(1): 48.
Lai XH, Zhao LF, Chen XM and Ren Y. Rapid Identification and Characterization of Francisella by Molecular Biology and Other Techniques. Open Micob. J. 2016. 10:64-77.
Sun YBY, Qu XL, Howard V, Dai L, Jiang XY, Ren Y, Caruana G, Bertram JF, Sleeman M, Li J*. Smad3 deficiency protects mice from obesity-induced podocyte injury which precedes insulin resistance. Kidney International. 2015. doi: 10.1038/ki.2015.121. PMID: 25945408
Lai XH, Xu YS, Chen XM and Ren Y*. Macrophage cell death upon intracellular bacterial infection. Macrophage. 2015. 2:e779. PMID: 26690967
Wang Xi, Cao K, Sun X, Chen YX, Duan ZX, Sun Li, Guo L, Bai P, Sun DM, Fan JQ, He XJ, Young W and Ren Y*. Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris. Glia. 2015. 63: 635–651. PMID: 25452166
Yao XM, Chan ZL, Shen DL, Zhou QH, Huang SS, Cai ZR, Tang YL, Wang M, Ren Y, Lai XH, and Chen XM*. Risk factors for pediatric intussusception complicated by loss of intestine viability in China from June 2009 to May 2014: a retrospective study. Ped. Surg. Int. 2015. 31(2):163-6. PMID: 25524017
Qu X, Jiang M, Sun YB, Jiang X, Fu P, Ren Y, Wang D, Dai L, Caruana G, Bertram JF, Nikolic-Paterson DJ, Li J*. The Smad3/Smad4/CDK9 complex promotes renal fibrosis in mice with unilateral ureteral obstruction. Kidney Int. 2015. 88:1323-1335.
Zhou X, He XJ and Ren Y*. Function of microglia and macrophages in secondary damage after spinal cord injury. Neural Regeneration Research. 2014. 9:1787-1795. Invited review. PMID: 25422640
Zhang J, Sun X, Zheng S, Liu X1 Jin J, Ren Y, Luo J*. Myelin Basic Protein Induces Neuron-Specific Toxicity by Directly Damaging the Neuronal Plasma Membrane. Plos ONE. 2014. 9(9): e108646. PMID: 25255088
Chen TX, Wang Xi, Guo L, Wu MM, Duan ZX, Lv J, Tai WJ, Renganathan H, Didier R, Li JH, Sun DM, Chen XM, He XJ, Fan JQ, Young W and Ren Y*. Embryonic stem cells promoting macrophage survival and function are crucial for teratoma development. Frontiers in Immunology. 2014. 5:1-16. PMID: 25071759
Qu X, Li Xl, Zheng YW, Ren Y, Puelles VG, Caruana G, Nikolic-Paterson D, and Li JH*. Regulation of Renal Fibrosis by Smad3 Thr388 Phosphorylation. Am. J. Path. 2014. 184:944-952. PMID: 24485922
Zhang XJ, Chen LW, Wang YZ, Ding YX, Peng ZW, Duan L, Ju G, Ren Y* and Wang X*. Macrophage Migration Inhibitory Factor Promotes Proliferation and Neuronal Differentiation of Neural Stem/Precursor Cells through Wnt/β-Catenin Signal Pathway. Int. J. Biol. Sci. 2013. 9:1108-1120. PMID: 24339732
Ren Y* and Young W. Managing inflammation after spinal cord injury through manipulation of macrophage function. Neural Plasticity. 2013. Vol. 2013: Article ID 945034. PMCID: PMC3833318. Invited review. PMID: 24288627
Wang X, Fan JQ, Lin, L, Cao K, Duan ZX, Chen TX, Zhang XJ, Shao CS, Tadmori I, Li TY, Sun DM, Zheng SS, Meinhardt A, Young W, Bucala R and Ren Y*. MIF Produced by Bone Marrow-Derived Macrophages Contributes to Teratoma Progression after Embryonic Stem Cell Transplantation. Cancer Res. 2012. 71:2867-2878. PMID: 22461508
Ren Y*. Peroxisome proliferator-activator receptor γ: a link between macrophage CD36 and inflammation in malaria infection. PPAR Res. 2012 Jan. Volume 2012:640769. Invited review. PMID: 22287954
Zhu ZZ, Kremer P, Tadmori I, Ren Y, Sun DM, He XJ and Young W*. Lithium Suppresses Astrogliogenesis by Neural Stem and Progenitor Cells by Inhibiting STAT3 Pathway Independently of Glycogen Synthase Kinase 3-b. PloS ONE. 2011. 6(9): e23341. PMID: 21931595
Shi LM, et al. The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nature Biotechnology. 2010. 28 (8): 827-838. PMID: 20676074
Sun X, Wang X, Chen TX, Li TY, Cao K, Lu A, Chen YX, Sun DM, Luo JH, Fan JQ, Young W and Ren Y*. Myelin activates FAK/Akt/NF-κB pathways and provokes CR3-dependent inflammatory response. PLoS ONE. 2010. 5(2):e9380. PMID: 20186338
Li W, Xie Y, Sun R, Liu Q, Young J, Yu WY, Che CM, Tam P and Ren Y*. Inhibition of Akt sensitizes neuroblastoma cells to gold(III) porphyrin 1a, a novel anti-tumor drug induced apoptosis and growth inhibition. British J. Cancer. 2009. 101:342-349. PMID: 19550420
Xie Y, Fan JQ, Chen JH, Huang FP, Cao B, Tam PKH and Ren Y*. A novel function for dendritic cell: clearance of VEGF via VEGF receptor-1. Biochem. Biophys. Res. Commun. 2009. 380: 243-248. PMID: 19167346
Ren Y*, Xie Y, Jiang GP, Fan JQ, Yeung J, Li W, Tam T and Savill J. Apoptotic cells protect mice against LPS-induced shock. J. Immunol. 2008. 180: 4978-4985. PMID: 18354223
Xie Y, Chan HM, Fan JQ, Chen YX, Young J, Li W, Miao XP, Yuan ZW, Wang HM, Tam P and Ren Y*. Involvement of Visinin Like Protein-1 (VSNL-1) in Regulating Proliferative and Invasive Properties of Neuroblastoma. Carcinogenesis. 2007. 28(10):2122-30. PMID: 17615261
Fan JQ and Ren Y. Statistical Analysis of DNA Microarray Data in Cancer Research. Clin. Cancer Res. 2006. 12(15):4469-4473. PMID: 16899590
Ren Y*, Chan HM, Fan JQ, Chen YX, Xie Y, Li W, Jiang GP, Liu Q, Meinhardt A and Tam P. Inhibition of Tumor Growth and Metastasis in vitro and in vivo by Targeting Macrophage Migration Inhibitory Factor in Human Neuroblastoma. Oncogene. 2006 Jun 15; 25(25):3501-8. PMID: 16449971
Fan JQ, Chen YX, Chan HM, Tam P and Ren Y*. Removing intensity effects and identifying significant genes for Affymetrix arrays in MIF-suppressed neuroblastoma cells. Proc. Natl. Acad. Sci. USA. 2005 Dec. 102 (49):17751-17756. PMID: 16314559
Ren Y*, Cao B, Law S, Xie Y, Lee PY, Cheung L, Chen YX, Huang X, Chan HM, Zhao P, Luk L, Vande Woude G and John Wong. Hepatocyte Growth Factor Promotes Cancer Cell Migration and Angiogenic Factors expression: A Prognostic Marker of Human Esophageal Squamous Cell Carcinomas. Clin. Cancer Res. 2005.Sep. 11(17): 6190-6197. PMID: 16144920
Ren Y*, Law S, Huang X, Lee PY, Li Z, Bacher M, Srivastava G and Wong J. Macrophage Migration Inhibitory Factor Stimulates Angiogenic Factors Expression, Correlates with Differentiation and Lymph Node Status in Patients with Esophageal Squamous Cell Carcinoma. Ann. Surg. 2005. 242 (1): 55-63. PMID: 15973102
Fan JQ, Huang T, Peng H and Ren Y. Semilinear high-dimensional model for normalization of microarray data: a theoretical analysis and partial consistency. J Am Stat Asso. 2005. Sep. 808-813.
Ren Y*, Lin CL, Li Z, Chen YX, Huang X, Lui V, Nicholls J, Lan HY and Tam P. Up-regulation of macrophage migration inhibitory factor in infants with acute neonatal necrotizing enterocolitis. Histopathology. 2005. 46(6):659-67. PMID: 15910597
He QY, Zhu R, Ren Y, Chiu JF and Tam P*. Serological Protein Profiling of Neuroblastoma by ProteinChip SELDI-TOF Technology. J. Cell Biochem. 2005. 95(1):165-72. PMID: 15759280
Ren Y*, He QY, Fan JQ, Jones B, Zhou Y, Xie Y, Cheung CY, Wu A, Chiu JF, Peiris JSM and Tam P. The Use of Proteomics in the Discovery of Serum Biomarkers from Patients with Severe Acute Respiratory Syndrome (SARS). Proteomics. 2004 Nov; 4(11):3477-84. PMID: 15378763
Fan JQ, Tam P, Vande Woude G and Ren Y*. Normalization and significant analysis of cDNA microarrays using within-array replications applied to tumor cells response to MIF. Proc. Natl. Acad. Sci. USA. 2004. 101 (5): 1135-1140. PMID: 14739336
Li Z, Ren Y, Lin SX, Liang YJ and Liang HZ. Association of E-cadherin and beta-catenin with metastasis in nasopharyngeal carcinoma. Chin Med J. 2004. 117(8):1232-9. PMID: 15361301
Ren Y*, Chen HM, Li Z, Lin CL, Nicholls J, Chen ZF, Lee PY, Lui V, Bacher M and Tam P. Up-regulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma. Oncogene. 2004 23(23):4146-54. PMID: 15064733
Li Z, Ren Y, Wu QC, Lin SX, Liang YJ and Liang HZ. Macrophage migration inhibitory factor enhances neoplastic cell invasion by inducing the expression of matrix metalloproteinase 9 and interleukin-8 in nasopharyngeal carcinoma cell lines. Chin Med J. 2004. 117(1):1017-14. PMID: 14733785
Ren Y*, Poon RTP, Tsui HT, Li Z, Lau C, Yu WC and Fan ST. Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinico-pathological features and prognosis. Clin. Cancer Res. 2003 Dec 9: 5996-6001. PMID: 14676125
Ren Y, Tang JL, MoK T, Chan AWK, Wu A and Lau CS*. Increased apoptotic blood neutrophils and macrophages and decreased clearance of apoptotic neutrophils in systemic lupus erythematosus. Arthritis & rheumatism. 2003 Oct 48 (10): 2888-97. PMID: 14558095
Ren Y*, Tsui HT, Poon RTP, Li Z, Chen YX, Lau C, Bacher M and Fan ST. Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma. Int. J. Cancer. 2003. 107; 22-29. PMID: 12925952
Lo LL, WF, Lee TH, Ren Y, Hwang SL, Cheng YF, Chen CL, Chang YS, Lee SP, Rickinson AB, Tam P*. Immunization with Epstein-Barr Virus (EBV) peptide-pulsed dendritic cells induces functional CD8+ T cell immunity and can lead to tumor regression in patients with EBV-positive nasopharyngeal carcinoma. Cancer Res. 2002 Dec 1;62(23):6952-8. PMID: 12460912
Ren Y, Stuart L, Lindberg FP, Rosenkranz AR, Chen Y, Mayadas TN and Savill J*. Nonphlogistic clearance of late apoptotic neutrophils by macrophages: efficient phagocytosis independent of b2 intergrins. J. Immunol. 2001 April; 166: 4743-4750. PMID: 11254736
Harper L, Ren Y, Savill J, Adu D, Savage CO*. Antineutrophil cytoplasmic antibodies induce superoxide-dependent dyregulation of primed neutrophil apoptosis and clearance by macrophages. Am J. Path. 2000 July; 157(1): 211-220. PMID: 10880391
Zhuang JG, Ren Y, Snowden RT, Zhu H, Gogvadze V, Savill J, and Cohen GM*. Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of apoptotic program. J. Biol. Chem. 1998; 273(25): 1528-32. PMID: 9624155
Ren Y, Savill J*. Apoptosis: The importance of being eaten. Cell Death. Differ.1998; 5(7): 563-8. PMID: 10200510
Navazo MDP, Daviet L, Savill J, Ren Y Leung LL, and McGregor JL*. Identification of a domain (155-183) on CD36 implied in the phagocytosis of apoptotic neutrophils. J. Biol. Chem.1996; 271(26): 1538-85. PMID: 8663130
Ren Y, Silverstein RL, Allen J and Savill J*. CD36 gene-transfer confers capacity for phagocytosis of cells undergoing apoptosis. J. Exp. Med. 1995; 181(5): 1857-62. PMID: 7536797
Ren Y, Savill J*. Proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergoing apoptosis. J. Immunol. 1995; 154(5): 2366-74. PMID: 7532668
Savill J*, Hogg N, Ren Y, and Haslett C*. Thrombospondin co-operates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J. Clin. Invest. 1992; 90: 1513-22. PMID: 1383273
Savill J*, Smith J, Sarraf C, Ren Y, Abbott F and Rees A*. Glomerular mesangial cells and inflammatory macrophages ingest neutrophils undergoing apoptosis. Kidney Int. 1992: 42: 924-36. PMID: 1333549
Book Chapter:
Yi Ren. The role of MIF on tumorigenicity of embryonic stem cells. In: The MIF Handbook. R. Bucala. Ed. World Sci. 305-318, 2012.