Pradeep Bhide Ph.D.
Professor; Jim and Betty Ann Rodgers Eminent Scholar Chair of Developmental Neuroscience; Director, FSU Institute for Pediatric Rare Diseases; Director, Center for Brain Repair
Biosketch
Dr. Pradeep G. Bhide is the Jim and Betty Ann Rodgers Eminent Scholar Chair of Developmental Neuroscience and the Director of the FSU Institute for Pediatric Rare Diseases and the Center for Brain Repair at the Florida State University College of Medicine.
Education
Dr. Bhide received his degree in Veterinary Medicine from Veterinary College, Bangalore, India, and a Ph.D. in neuroscience from the University of Aberdeen, Scotland. He received postdoctoral training in developmental neurobiology at University College London, England; Yale School of Medicine, New Haven, CT; and Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Service
Administrative Responsibilities
Director, Interdepartmental Neuroscience Center, Massachusetts General Hospital, Boston, MA (2003-11)
Vice Chair for Neurology Research, Massachusetts General Hospital, Boston, MA (2007-11)
Director, Center for Brain Repair, FSU College of Medicine (2011-present)
Director, FSU Institute for Pediatric Rare Diseases, FSU College of Medicine (2024-present)
Editorial Boards
Senior Editor, Developmental Neuroscience (2009-present)
Editorial Board, Developmental Neuroscience (2005-present)
Editorial Board: Current Neuropharmacology (2009-present)
Associate Editor, Frontiers in Neurogenesis (2022-present)
Editorial Board: Neurotoxicology and Teratology Neurotoxicology and Teratology (2022-present)
Honors/Awards
MRC (UK) Research Assistantship
Wellcome Trust (UK) Fellowship
Charles A. King Trust Fellowship, Boston, MA
Montreal Neurological Institute Young Investigator Award, Montreal, Canada
Partners in Excellence - Leadership and Innovation Award Massachusetts General Hospital, Boston, MA
Outstanding Senior Faculty Researcher Award Florida State University Faculty Council, Tallahassee, FL
Memberships
Developmental Neurotoxicology Society
American Professional Society of ADHD and Related Disorders
Courses
Neuroscience: CNS and Behavior (BMS 6046C)
Foundations of Medicine 2
Musculoskeletal and Integumentary Systems
Biomedical Innovation and Entrepreneurship
Research Focus
The research in the Bhide laboratory focuses on developmental neurological and psychiatric conditions including early-onset generalized dystonia, ADHD and Fragile X Syndrome. Another area of research focus is the neurological and cognitive effects of prenatal and early postnatal exposure to addictive substances.
Current research projects include examination of the role of dopamine receptor activation in the developing brain; the effects of prenatal exposure to cocaine, nicotine and non-nutritive sweetners on the development of the brain and behavior; and the developmental origins of the movement disorder generalized dystonia.
Dr. Bhide’s laboratory employs a variety of technologies including microscopy, histology, biochemistry and molecular biology, cell and tissue culture, neuropharmacology, and behavioral analysis.
Research Group
Research Faculty
Deirdre McCarthy, B.Sc.
Graduate Students
Amber Parnell, B.S.
Mia Trupiano, B.S.
Undergraduate Students
Megan Peruse
Elizabeth Wasson
Publications
Recent publications
McCarthy, D.M., Vied, C., Trupiano, M.X., Canekeratne, A.J., Wang, Y., Schatschneider, C., Bhide, P.G. (In Press) Behavioral, neurotransmitter and transcriptomic analyses in male and female Fmr1 knockout mice. Front. Behav. Neurosci.
Espinoza, P., Cheng, M., Ng, C., de la Cruz, D., Wasson, E.D.,, McCarthy, D.M., Bhide, P.G., Maguire, C.A., and Santoscoy, M.C. (2024) Metabolic engineering improves transduction efficiency and downstream vector isolation by altering the lipid composition of extracellular vesicle-enclosed AAV. BioRxiv. doi: https://doi.org/10.1101/2024.08.16.608303
McCarthy, D.M., Spencer, T.J., Bhide, P.G. (2023) Preclinical Models of Attention Deficit Hyperactivity Disorder: Neurobiology, Drug Discovery, and Beyond. J Atten Disord. 10870547231215286. https://www.ncbi.nlm.nih.gov/pubmed/38084074
Jones, S.K., McCarthy, D.M., Stanwood, G.D., Schatschneider, C., Bhide, P.G. 2023. Learning and memory deficits produced by aspartame are heritable via the paternal lineage. Sci. Reports. 13(1) 14326. https://doi.org/10.1038/s41598-023-41213-2
Jones, S.K., McCarthy, D.M., Vied, C., Stanwood, G.D., Schatschneider, C., Bhide, P.G. 2022. Transgenerational transmission of aspartame-induced anxiety and changes in glutamate-GABA signaling and gene expression in the amygdala. Proc. Natl. Acad. Sci. USA. 119 (14): e2213120119. www.pnas.org/doi/10.1073/pnas.2213120119
McCarthy, D.M., Zhang, L., Wilkes, B.J., Vaillancourt, D.E., Biederman, J., Bhide, P.G., 2022. Nicotine and the developing brain: Insights from preclinical models. Pharmacol Biochem Behav, Feb 14;173355. doi: 10.1016/j.pbb.2022.173355. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063417/
Zhang, L., Levenson, C.W., Salazar, V.C., Biederman, J., Zafonte, R., Bhide, P.G., 2022. Repetitive Mild Traumatic Brain Injury in an Awake, Unanesthetized Mouse Model of Perinatal Nicotine Exposure Produces Transient Novelty-Seeking and Depression-Like Behaviors. J Neurotrauma. DOI 10.1089/neu.2021.0268 https://pubmed.ncbi.nlm.nih.gov/34913733/
McCarthy DM, Bhide PG. Heritable consequences of paternal nicotine exposure: From phenomena to mechanisms. Biology of reproduction. 2021; Epub 2021/06/15. doi: 10.1093/biolre/ioab116. PubMed PMID: 34126634. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444703/
Zhang L, Levenson CW, Salazar VC, McCarthy DM, Biederman J, Zafonte R, Bhide PG. "Repetitive Mild Traumatic Brain Injury in a Perinatal Nicotine Exposure Mouse Model of Attention Deficit Hyperactivity Disorder." Dev Neurosci. 2021;43(1):1-10. PubMed PMID: 33849015. https://www.karger.com/Article/FullText/515198
Zhang L, McCarthy DM, Eskow Jaunarajs KL, Biederman J, Spencer TJ, Bhide PG. "Frontal Cortical Monoamine Release, Attention, and Working Memory in a Perinatal Nicotine Exposure Mouse Model Following Kappa Opioid Receptor Antagonism." Cerebral Cortex. 2021;31(1):483-96. doi: 10.1093/cercor/bhaa238 https://pubmed.ncbi.nlm.nih.gov/32869057/
Martin MM, McCarthy DM, Schatschneider C, Trupiano MX, Jones SK, Kalluri A, Bhide PG. "Effects of Developmental Nicotine Exposure on Frontal Cortical GABA-to-Non-GABA Neuron Ratio and Novelty-Seeking Behavior." Cereb Cortex. 2020;30:1830-42. PubMed PMID: 31599922 https://pubmed.ncbi.nlm.nih.gov/31599922/
McCarthy DM, Lowe SE, Morgan TJ, Cannon EN, Biederman J, Spencer TJ, Bhide PG. "Transgenerational transmission of behavioral phenotypes produced by exposure of male mice to saccharin and nicotine." Sci Rep. 2020;10(1):11974. PubMed PMID: 32686722; PMCID: PMC7371742. https://www.nature.com/articles/s41598-020-68883-6
McCarthy DM, Morgan TJ, Jr., Lowe SE, Williamson MJ, Spencer TJ, Biederman J, Bhide, PG (2018). "Nicotine exposure of male mice produces behavioral impairment in multiple generations of descendants." PLoS Biol. 16:e2006497. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2006497
Zhang L, Spencer TJ, Biederman J, Bhide PG (2018). "Attention and working memory deficits in a perinatal nicotine exposure mouse model." PLoS One. 13:e0198064. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198064
Spencer TJ, Bhide P, Zhu J, Faraone SV, Fitzgerald M, Yule AM, Uchida M, Spencer AE, Hall AM, Koster AJ, Feinberg L, Kassabian S, Storch B, Biederman J. "The Mixed Opioid Receptor Antagonist Naltrexone Mitigates Stimulant-Induced Euphoria: A Double-Blind, Placebo-Controlled Trial of Naltrexone." J Clin Psychiatry. 2018;79(2):17m11609. doi: 10.4088/JCP.17m11609. PubMed PMID: 29617066. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548180/
Spencer TJ, Bhide P, Zhu J, Faraone SV, Fitzgerald M, Yule AM, Uchida M, Spencer AE, Hall AM, Koster AJ, Biederman J. "Opiate Antagonists Do Not Interfere With the Clinical Benefits of Stimulants in ADHD: A Double-Blind, Placebo-Controlled Trial of the Mixed Opioid Receptor Antagonist Naltrexone." J Clin Psychiatry. 2017. doi: 10.4088/JCP.16m11012. PubMed PMID: 28640990. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438372/
Dr. Pradeep G. Bhide is the Jim and Betty Ann Rodgers Eminent Scholar Chair of Developmental Neuroscience and the Director of the FSU Institute for Pediatric Rare Diseases and the Center for Brain Repair at the Florida State University College of Medicine.
Dr. Bhide received his degree in Veterinary Medicine from Veterinary College, Bangalore, India, and a Ph.D. in neuroscience from the University of Aberdeen, Scotland. He received postdoctoral training in developmental neurobiology at University College London, England; Yale School of Medicine, New Haven, CT; and Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Administrative Responsibilities
Director, Interdepartmental Neuroscience Center, Massachusetts General Hospital, Boston, MA (2003-11)
Vice Chair for Neurology Research, Massachusetts General Hospital, Boston, MA (2007-11)
Director, Center for Brain Repair, FSU College of Medicine (2011-present)
Director, FSU Institute for Pediatric Rare Diseases, FSU College of Medicine (2024-present)
Editorial Boards
Senior Editor, Developmental Neuroscience (2009-present)
Editorial Board, Developmental Neuroscience (2005-present)
Editorial Board: Current Neuropharmacology (2009-present)
Associate Editor, Frontiers in Neurogenesis (2022-present)
Editorial Board: Neurotoxicology and Teratology Neurotoxicology and Teratology (2022-present)
MRC (UK) Research Assistantship
Wellcome Trust (UK) Fellowship
Charles A. King Trust Fellowship, Boston, MA
Montreal Neurological Institute Young Investigator Award, Montreal, Canada
Partners in Excellence - Leadership and Innovation Award Massachusetts General Hospital, Boston, MA
Outstanding Senior Faculty Researcher Award Florida State University Faculty Council, Tallahassee, FL
Neuroscience: CNS and Behavior (BMS 6046C)
Foundations of Medicine 2
Musculoskeletal and Integumentary Systems
Biomedical Innovation and Entrepreneurship
The research in the Bhide laboratory focuses on developmental neurological and psychiatric conditions including early-onset generalized dystonia, ADHD and Fragile X Syndrome. Another area of research focus is the neurological and cognitive effects of prenatal and early postnatal exposure to addictive substances.
Current research projects include examination of the role of dopamine receptor activation in the developing brain; the effects of prenatal exposure to cocaine, nicotine and non-nutritive sweetners on the development of the brain and behavior; and the developmental origins of the movement disorder generalized dystonia.
Dr. Bhide’s laboratory employs a variety of technologies including microscopy, histology, biochemistry and molecular biology, cell and tissue culture, neuropharmacology, and behavioral analysis.
Research Group
Research Faculty
Deirdre McCarthy, B.Sc.
Graduate Students
Amber Parnell, B.S.
Mia Trupiano, B.S.
Undergraduate Students
Megan Peruse
Elizabeth Wasson
Recent publications
McCarthy, D.M., Vied, C., Trupiano, M.X., Canekeratne, A.J., Wang, Y., Schatschneider, C., Bhide, P.G. (In Press) Behavioral, neurotransmitter and transcriptomic analyses in male and female Fmr1 knockout mice. Front. Behav. Neurosci.
Espinoza, P., Cheng, M., Ng, C., de la Cruz, D., Wasson, E.D.,, McCarthy, D.M., Bhide, P.G., Maguire, C.A., and Santoscoy, M.C. (2024) Metabolic engineering improves transduction efficiency and downstream vector isolation by altering the lipid composition of extracellular vesicle-enclosed AAV. BioRxiv. doi: https://doi.org/10.1101/2024.08.16.608303
McCarthy, D.M., Spencer, T.J., Bhide, P.G. (2023) Preclinical Models of Attention Deficit Hyperactivity Disorder: Neurobiology, Drug Discovery, and Beyond. J Atten Disord. 10870547231215286. https://www.ncbi.nlm.nih.gov/pubmed/38084074
Jones, S.K., McCarthy, D.M., Stanwood, G.D., Schatschneider, C., Bhide, P.G. 2023. Learning and memory deficits produced by aspartame are heritable via the paternal lineage. Sci. Reports. 13(1) 14326. https://doi.org/10.1038/s41598-023-41213-2
Jones, S.K., McCarthy, D.M., Vied, C., Stanwood, G.D., Schatschneider, C., Bhide, P.G. 2022. Transgenerational transmission of aspartame-induced anxiety and changes in glutamate-GABA signaling and gene expression in the amygdala. Proc. Natl. Acad. Sci. USA. 119 (14): e2213120119. www.pnas.org/doi/10.1073/pnas.2213120119
McCarthy, D.M., Zhang, L., Wilkes, B.J., Vaillancourt, D.E., Biederman, J., Bhide, P.G., 2022. Nicotine and the developing brain: Insights from preclinical models. Pharmacol Biochem Behav, Feb 14;173355. doi: 10.1016/j.pbb.2022.173355. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063417/
Zhang, L., Levenson, C.W., Salazar, V.C., Biederman, J., Zafonte, R., Bhide, P.G., 2022. Repetitive Mild Traumatic Brain Injury in an Awake, Unanesthetized Mouse Model of Perinatal Nicotine Exposure Produces Transient Novelty-Seeking and Depression-Like Behaviors. J Neurotrauma. DOI 10.1089/neu.2021.0268 https://pubmed.ncbi.nlm.nih.gov/34913733/
McCarthy DM, Bhide PG. Heritable consequences of paternal nicotine exposure: From phenomena to mechanisms. Biology of reproduction. 2021; Epub 2021/06/15. doi: 10.1093/biolre/ioab116. PubMed PMID: 34126634. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444703/
Zhang L, Levenson CW, Salazar VC, McCarthy DM, Biederman J, Zafonte R, Bhide PG. "Repetitive Mild Traumatic Brain Injury in a Perinatal Nicotine Exposure Mouse Model of Attention Deficit Hyperactivity Disorder." Dev Neurosci. 2021;43(1):1-10. PubMed PMID: 33849015. https://www.karger.com/Article/FullText/515198
Zhang L, McCarthy DM, Eskow Jaunarajs KL, Biederman J, Spencer TJ, Bhide PG. "Frontal Cortical Monoamine Release, Attention, and Working Memory in a Perinatal Nicotine Exposure Mouse Model Following Kappa Opioid Receptor Antagonism." Cerebral Cortex. 2021;31(1):483-96. doi: 10.1093/cercor/bhaa238 https://pubmed.ncbi.nlm.nih.gov/32869057/
Martin MM, McCarthy DM, Schatschneider C, Trupiano MX, Jones SK, Kalluri A, Bhide PG. "Effects of Developmental Nicotine Exposure on Frontal Cortical GABA-to-Non-GABA Neuron Ratio and Novelty-Seeking Behavior." Cereb Cortex. 2020;30:1830-42. PubMed PMID: 31599922 https://pubmed.ncbi.nlm.nih.gov/31599922/
McCarthy DM, Lowe SE, Morgan TJ, Cannon EN, Biederman J, Spencer TJ, Bhide PG. "Transgenerational transmission of behavioral phenotypes produced by exposure of male mice to saccharin and nicotine." Sci Rep. 2020;10(1):11974. PubMed PMID: 32686722; PMCID: PMC7371742. https://www.nature.com/articles/s41598-020-68883-6
McCarthy DM, Morgan TJ, Jr., Lowe SE, Williamson MJ, Spencer TJ, Biederman J, Bhide, PG (2018). "Nicotine exposure of male mice produces behavioral impairment in multiple generations of descendants." PLoS Biol. 16:e2006497. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2006497
Zhang L, Spencer TJ, Biederman J, Bhide PG (2018). "Attention and working memory deficits in a perinatal nicotine exposure mouse model." PLoS One. 13:e0198064. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198064
Spencer TJ, Bhide P, Zhu J, Faraone SV, Fitzgerald M, Yule AM, Uchida M, Spencer AE, Hall AM, Koster AJ, Feinberg L, Kassabian S, Storch B, Biederman J. "The Mixed Opioid Receptor Antagonist Naltrexone Mitigates Stimulant-Induced Euphoria: A Double-Blind, Placebo-Controlled Trial of Naltrexone." J Clin Psychiatry. 2018;79(2):17m11609. doi: 10.4088/JCP.17m11609. PubMed PMID: 29617066. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548180/
Spencer TJ, Bhide P, Zhu J, Faraone SV, Fitzgerald M, Yule AM, Uchida M, Spencer AE, Hall AM, Koster AJ, Biederman J. "Opiate Antagonists Do Not Interfere With the Clinical Benefits of Stimulants in ADHD: A Double-Blind, Placebo-Controlled Trial of the Mixed Opioid Receptor Antagonist Naltrexone." J Clin Psychiatry. 2017. doi: 10.4088/JCP.16m11012. PubMed PMID: 28640990. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438372/