Deirdre M McCarthy
Research Faculty II
Job Description
Deirdre McCarthy is research faculty in the Department of Biomedical Sciences and Center for Brain Repair. Her research interests focus on developmental and behavioral neuroscience.
Education
2001 Bachelor's degree, University of Cork, Ireland. Major: Biochemistry
Service
Voting Member, Animal Care and Use Committee (2015–2020)
Honors/Awards
Outstanding Junior Faculty Investigator Award, FSU College of Medicine (2017). Best Presentation Award, 2017 APSARD Annual Meeting (2017).
Memberships
Professional Women's Nexus, Society for Neuroscience, American Professional Society of ADHD and Related Disorders
Research Focus
Role of dopamine receptor and BDNF signaling in a prenatal cocaine exposure mouse model. Dopamine dysfunction in mouse models of Dystonia. Impact of nicotine exposure on subsequent generations in mouse models of paternal and maternal nicotine exposure.
Publications
Recent relevant publications
1. Zhang L, Levenson CW, Salazar VC, McCarthy DM, Biederman J, Zafonte R, Bhide PG.
Repetitive Mild Traumatic Brain Injury in a Perinatal Nicotine Exposure Mouse
Model of Attention Deficit Hyperactivity Disorder. Dev Neurosci.
2021;43(1):63-72. doi: 10.1159/000515198. Epub 2021 Apr 13. PubMed [citation]
PMID: 33849015
2. Pavlock S, McCarthy DM, Kesarwani A, Jean-Pierre P, Bhide PG. Hippocampal
neuroinflammation following combined exposure to cyclophosphamide and naproxen in
ovariectomized mice. Int J Neurosci. 2021 Mar 10:1-10. doi:
10.1080/00207454.2021.1896508. [Epub ahead of print] PubMed [citation] PMID:
33635748
3. Biederman J, Fitzgerald M, Spencer TJ, Bhide PG, McCarthy DM, Woodworth KY,
Saunders A, Faraone SV. Is Paternal Smoking at Conception a Risk for ADHD? A
Controlled Study in Youth With and Without ADHD. J Atten Disord. 2020
Sep;24(11):1493-1496. doi: 10.1177/1087054717690809. Epub 2017 Feb 2. PubMed
[citation] PMID: 28152645
4. McCarthy DM, Lowe SE, Morgan TJ, Cannon EN, Biederman J, Spencer TJ, Bhide PG.
Transgenerational transmission of behavioral phenotypes produced by exposure of
male mice to saccharin and nicotine. Sci Rep. 2020 Jul 20;10(1):11974. doi:
10.1038/s41598-020-68883-6. PubMed [citation] PMID: 32686722, PMCID: PMC7371742
5. Martin MM, McCarthy DM, Schatschneider C, Trupiano MX, Jones SK, Kalluri A, Bhide
PG. Effects of Developmental Nicotine Exposure on Frontal Cortical
GABA-to-Non-GABA Neuron Ratio and Novelty-Seeking Behavior. Cereb Cortex. 2020
Mar 14;30(3):1830-1842. doi: 10.1093/cercor/bhz207. PubMed [citation] PMID:
31599922, PMCID: PMC7305802
6. McCarthy DM, Morgan TJ Jr, Lowe SE, Williamson MJ, Spencer TJ, Biederman J, Bhide
PG. Nicotine exposure of male mice produces behavioral impairment in multiple
generations of descendants. PLoS Biol. 2018 Oct 16;16(10):e2006497. doi:
10.1371/journal.pbio.2006497. eCollection 2018 Oct. PubMed [citation] PMID:
30325916, PMCID: PMC6191076
7. Jones L, Goode L, Davila E, Brown A, McCarthy DM, Sharma N, Bhide PG, Armata IA.
Translational effects and coding potential of an upstream open reading frame
associated with DOPA Responsive Dystonia. Biochim Biophys Acta Mol Basis Dis.
2017 Jun;1863(6):1171-1182. doi: 10.1016/j.bbadis.2017.03.024. Epub 2017 Mar 31.
PubMed [citation] PMID: 28366877, PMCID: PMC6766408
8. Zhu J, Fan F, McCarthy DM, Zhang L, Cannon EN, Spencer TJ, Biederman J, Bhide PG.
A prenatal nicotine exposure mouse model of methylphenidate responsive
ADHD-associated cognitive phenotypes. Int J Dev Neurosci. 2017 May;58:26-34. doi:
10.1016/j.ijdevneu.2017.01.014. Epub 2017 Feb 4. PubMed [citation] PMID: 28179105
9. McCarthy DM, Mueller KA, Cannon EN, Huizenga MN, Darnell SB, Bhide PG,
Sadri-Vakili G. Prenatal Cocaine Exposure Alters BDNF-TrkB Signaling in the
Embryonic and Adult Brain. Dev Neurosci. 2016;38(5):365-374. doi:
10.1159/000453609. Epub 2017 Jan 28. PubMed [citation] PMID: 28132054
10. McCarthy DM, Bell GA, Cannon EN, Mueller KA, Huizenga MN, Sadri-Vakili G, Fadool
DA, Bhide PG. Reversal Learning Deficits Associated with Increased Frontal
Cortical Brain-Derived Neurotrophic Factor Tyrosine Kinase B Signaling in a
Prenatal Cocaine Exposure Mouse Model. Dev Neurosci. 2016;38(5):354-364. doi:
10.1159/000452739. Epub 2016 Dec 13. PubMed [citation] PMID: 27951531, PMCID:
PMC5360472
11. Martin MM, Graham DL, McCarthy DM, Bhide PG, Stanwood GD. Cocaine-induced
neurodevelopmental deficits and underlying mechanisms. Birth Defects Res C Embryo
Today. 2016 Jun;108(2):147-73. doi: 10.1002/bdrc.21132. Review. PubMed [citation]
PMID: 27345015, PMCID: PMC5538582
12. Zhang L, McCarthy DM, Sharma N, Bhide PG. Dopamine receptor and Gα(olf)
expression in DYT1 dystonia mouse models during postnatal development. PLoS One.
2015 Apr 10;10(4):e0123104. doi: 10.1371/journal.pone.0123104. eCollection 2015.
PubMed [citation] PMID: 25860259, PMCID: PMC4393110
Deirdre McCarthy is research faculty in the Department of Biomedical Sciences and Center for Brain Repair. Her research interests focus on developmental and behavioral neuroscience.
2001 Bachelor's degree, University of Cork, Ireland. Major: Biochemistry
Voting Member, Animal Care and Use Committee (2015–2020)
Outstanding Junior Faculty Investigator Award, FSU College of Medicine (2017). Best Presentation Award, 2017 APSARD Annual Meeting (2017).
Professional Women's Nexus, Society for Neuroscience, American Professional Society of ADHD and Related Disorders
Role of dopamine receptor and BDNF signaling in a prenatal cocaine exposure mouse model. Dopamine dysfunction in mouse models of Dystonia. Impact of nicotine exposure on subsequent generations in mouse models of paternal and maternal nicotine exposure.
Recent relevant publications
1. Zhang L, Levenson CW, Salazar VC, McCarthy DM, Biederman J, Zafonte R, Bhide PG.
Repetitive Mild Traumatic Brain Injury in a Perinatal Nicotine Exposure Mouse
Model of Attention Deficit Hyperactivity Disorder. Dev Neurosci.
2021;43(1):63-72. doi: 10.1159/000515198. Epub 2021 Apr 13. PubMed [citation]
PMID: 33849015
2. Pavlock S, McCarthy DM, Kesarwani A, Jean-Pierre P, Bhide PG. Hippocampal
neuroinflammation following combined exposure to cyclophosphamide and naproxen in
ovariectomized mice. Int J Neurosci. 2021 Mar 10:1-10. doi:
10.1080/00207454.2021.1896508. [Epub ahead of print] PubMed [citation] PMID:
33635748
3. Biederman J, Fitzgerald M, Spencer TJ, Bhide PG, McCarthy DM, Woodworth KY,
Saunders A, Faraone SV. Is Paternal Smoking at Conception a Risk for ADHD? A
Controlled Study in Youth With and Without ADHD. J Atten Disord. 2020
Sep;24(11):1493-1496. doi: 10.1177/1087054717690809. Epub 2017 Feb 2. PubMed
[citation] PMID: 28152645
4. McCarthy DM, Lowe SE, Morgan TJ, Cannon EN, Biederman J, Spencer TJ, Bhide PG.
Transgenerational transmission of behavioral phenotypes produced by exposure of
male mice to saccharin and nicotine. Sci Rep. 2020 Jul 20;10(1):11974. doi:
10.1038/s41598-020-68883-6. PubMed [citation] PMID: 32686722, PMCID: PMC7371742
5. Martin MM, McCarthy DM, Schatschneider C, Trupiano MX, Jones SK, Kalluri A, Bhide
PG. Effects of Developmental Nicotine Exposure on Frontal Cortical
GABA-to-Non-GABA Neuron Ratio and Novelty-Seeking Behavior. Cereb Cortex. 2020
Mar 14;30(3):1830-1842. doi: 10.1093/cercor/bhz207. PubMed [citation] PMID:
31599922, PMCID: PMC7305802
6. McCarthy DM, Morgan TJ Jr, Lowe SE, Williamson MJ, Spencer TJ, Biederman J, Bhide
PG. Nicotine exposure of male mice produces behavioral impairment in multiple
generations of descendants. PLoS Biol. 2018 Oct 16;16(10):e2006497. doi:
10.1371/journal.pbio.2006497. eCollection 2018 Oct. PubMed [citation] PMID:
30325916, PMCID: PMC6191076
7. Jones L, Goode L, Davila E, Brown A, McCarthy DM, Sharma N, Bhide PG, Armata IA.
Translational effects and coding potential of an upstream open reading frame
associated with DOPA Responsive Dystonia. Biochim Biophys Acta Mol Basis Dis.
2017 Jun;1863(6):1171-1182. doi: 10.1016/j.bbadis.2017.03.024. Epub 2017 Mar 31.
PubMed [citation] PMID: 28366877, PMCID: PMC6766408
8. Zhu J, Fan F, McCarthy DM, Zhang L, Cannon EN, Spencer TJ, Biederman J, Bhide PG.
A prenatal nicotine exposure mouse model of methylphenidate responsive
ADHD-associated cognitive phenotypes. Int J Dev Neurosci. 2017 May;58:26-34. doi:
10.1016/j.ijdevneu.2017.01.014. Epub 2017 Feb 4. PubMed [citation] PMID: 28179105
9. McCarthy DM, Mueller KA, Cannon EN, Huizenga MN, Darnell SB, Bhide PG,
Sadri-Vakili G. Prenatal Cocaine Exposure Alters BDNF-TrkB Signaling in the
Embryonic and Adult Brain. Dev Neurosci. 2016;38(5):365-374. doi:
10.1159/000453609. Epub 2017 Jan 28. PubMed [citation] PMID: 28132054
10. McCarthy DM, Bell GA, Cannon EN, Mueller KA, Huizenga MN, Sadri-Vakili G, Fadool
DA, Bhide PG. Reversal Learning Deficits Associated with Increased Frontal
Cortical Brain-Derived Neurotrophic Factor Tyrosine Kinase B Signaling in a
Prenatal Cocaine Exposure Mouse Model. Dev Neurosci. 2016;38(5):354-364. doi:
10.1159/000452739. Epub 2016 Dec 13. PubMed [citation] PMID: 27951531, PMCID:
PMC5360472
11. Martin MM, Graham DL, McCarthy DM, Bhide PG, Stanwood GD. Cocaine-induced
neurodevelopmental deficits and underlying mechanisms. Birth Defects Res C Embryo
Today. 2016 Jun;108(2):147-73. doi: 10.1002/bdrc.21132. Review. PubMed [citation]
PMID: 27345015, PMCID: PMC5538582
12. Zhang L, McCarthy DM, Sharma N, Bhide PG. Dopamine receptor and Gα(olf)
expression in DYT1 dystonia mouse models during postnatal development. PLoS One.
2015 Apr 10;10(4):e0123104. doi: 10.1371/journal.pone.0123104. eCollection 2015.
PubMed [citation] PMID: 25860259, PMCID: PMC4393110